Thirty-nine cases of intracranial hemangiopericytoma and anaplastic hemangiopericytoma: A retrospective review of MRI features and pathological findings

Zhang, Junlin; Liu, Jianli; Zhang, Jing; Zhang, Ming

doi:10.1016/j.ejrad.2012.04.034

Cited by 47 publications

(41 citation statements)

References 6 publications

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“…On gross pathological examination, the lesion may manifest as a solitary nodule with a complete or incomplete capsule. In a study conducted by Zhou et al ( 11 ) examining 39 cases intracranial HPC and anaplastic HPC, the majority of the anaplastic HPC cases presented with an incomplete capsule and ill-defined boundary, but intracranial HPC had a complete capsule and clear boundary. The results of the present study are similar to those findings.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging of intracranial hemangiopericytoma and correlation with pathological findings

Xu²,

Xiao

et al. 2014

Oncology Letters

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The present study aimed to evaluate the radiological and pathological features of intracranial hemangiopericytoma, and improve the understanding of this tumor. A retrospective analysis of radiological and pathological features of five cases of intracranial hemangiopericytoma was conducted between 2006 and 2012 in the Second Xiangya Hospital of Central South University. A total of five cases (three males and two females; aged 37–60 years) were enrolled. Magnetic resonance imaging revealed that the lesions were lobulated with iso-intensity T1-weighted image signals and slightly long T2-weighted image signals. Cystic degeneration, necrosis and flow void were observed. The case with the lesion located under the tentorium cerebelli exhibited compression of the fourth ventricle with lateral ventricle dilatation hydrocephalus. In all cases, the solid section of the lesion was markedly enhanced following injection of the contrast agent, and intratumoral vessels were observed. No case exhibited the dural tail sign. Immunohistochemical examination revealed positive expression of cluster of differentiation 34(CD34), vimentin and CD99, and negative expression of epithelial membrane antigen, S100 and glial fibrillary acidic protein. Proliferating cell nuclear antigen Ki-67 immunohistochemical staining revealed that <5% of cells expressed Ki-67 in two cases and 5–10% of cells expressed Ki-67 in three cases. In conclusion, intracranial hemangiopericytoma exhibits certain distinctive characteristics in radiological examination, allowing for improved diagnosis. However, pathological examination is required for confirmation.

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Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging of intracranial hemangiopericytoma and correlation with pathological findings

Xu²,

Xiao

et al. 2014

Oncology Letters

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“…Since HPCs are difficult to differentiate radiographically from other skull base tumors such as meningiomas, SFTs, and schwannomas; some authors such as Salunke et al [ 8 ] insist on the importance of preoperative planning in suspicious cases of CPA dura based masses and lesions showing disproportionate perilesional edema, narrow base of attachment, or multilobulated cross-leaf growth [ 12 ]. Other authors have proposed subtle imaging characteristics that may help to distinguish HPCs from meningiomas, such as the absence of calcification or bony hyperostosis, or the comparison of the apparent diffusion coefficient values in peritumoral edema [ 8 13 ].…”

Section: Discussionmentioning

confidence: 99%

Hemangiopericytoma of the Cerebellopontine Angle: A Wolf in Sheep's Clothing

Nsir

Badri

Kassar

et al. 2016

Brain Tumor Res Treat

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Primary meningeal hemangiopericytoma (HPC) is a rare, aggressive dura based tumor that remarkably mimics a meningioma clinically and radiologically. Its occurrence within the cerebellopontine angle (CPA) is exceptional, and establishing the exact diagnosis is of the utmost importance since total resection remains the cornerstone of treatment. A 42-year-old man presented with a three-month history of progressively worsening vertigo and difficulty in walking. On admission, his neurological examination revealed a right peripheral facial palsy, right abducens palsy and left hemiparesis, suggesting the diagnosis of Millard-Gubler syndrome. Computed tomography and magnetic resonance imaging demonstrated a homogeneously enhancing dura based lesion of the right CPA causing major brain stem compression. There was no widening of the ipsilateral internal auditory canal. A standard retrosigmoid craniotomy was performed to access the right CPA. Exposure of the lesion revealed a well-encapsulated, gray, fibrous lesion, which appeared to originate from the tentorium. Gross total resection was achieved and confirmed radiologically. The microscopic features and the immunohistochemical profile confirmed the diagnosis of a HPC, and adjuvant radiation therapy was administered. Ten years later, the patient presented with a severe neurological deficit due to a local recurrence, but at that time refused any second intervention. He died three months later. HPC can locate within the CPA and present as a Millard-Gubler syndrome. The diagnosis should be kept in mind in case of a CPA dura based tumor. Radical surgery plus radiation therapy can maximize the recurrence-free survival and close follow-up remains mandatory to spot recurrences early.

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“…32 The MRI appearance of intracranial HPCs may be similar to that of meningiomas. Unique HPC-related features include a narrow base of attachment, an irregular/multilobulated cross-leaf growth, the absence of intratumoral calcifications, the absence of related osseous hyperostosis, 33 bone erosion, and heterogeneous gadolinium contrast enhancement. 34 Cranial HPCs are typically isointense with gray matter on both T1-and T2-weighted MRI sequences.…”

Section: Cranial Hemangiopericytomasmentioning

confidence: 99%

“…Mixed signals when noted were shown to be associated with the grade-III (anaplastic) aggressive HPC type. 33 A "dural tail" is seen in 30% of grade-II patients. 34 The grade-III anaplastic HPC variant is marked by the presence of necrosis, cystic changes, and extensive peritumoral edema.…”

Section: Cranial Hemangiopericytomasmentioning

confidence: 99%

“…34 The grade-III anaplastic HPC variant is marked by the presence of necrosis, cystic changes, and extensive peritumoral edema. 33 Diffusionweighted imaging in grade-III HPCs is marked by higher ADC values compared to grade-II HPCs, meningioma, or with the normal surrounding brain. 34,35 Whole-tumor histogram analysis of ADC maps may be a useful tool for differential diagnosis, with ADCmin and ADC5 being potential parameters.…”

Section: Cranial Hemangiopericytomasmentioning

confidence: 99%

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Nervous System Hemangiopericytoma

Cohen-Inbar

2019

Can. J. Neurol. Sci.

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Abstract:The management of patients harboring central nervous system (CNS) hemangiopericytomas (HPCs) is a partially answered challenge. These are rare locally aggressive lesions, with potential for local recurrence, distal neural metastasis (DNM), and extraneural metastasis (ENM). Resection, when feasible, remains the initial treatment option, providing histological diagnosis and immediate relief of tumor-related mass effect. Patients receiving surgery alone or surgery and external beam radiotherapy (EBRT) show improved overall survival (OS) and progression-free survival as compared to those undergoing a biopsy alone (p = 0.01 and p = 0.02, respectively). Yet, in many instances, patient and tumor-related parameters preclude complete resection. EBRT or stereotactic radiosurgery (SRS) shares a significant role in achieving local tumor control, not shown to impact OS in HPC patients. The benefits of SRS/EBRT are clearly limited to improved local tumor volume control and neurologic function, not affecting DNM or ENM development. SRS provides acceptable rates of local tumor volume control coupled with treatment safety and a patient-friendly apparatus and procedure. Single-session SRS is most effective for lesions measuring <2 cm in their largest diameter (10 cm3 volume), with prescription doses of at >15 Gy. Systemic HPC disease is managed with various chemotherapeutic, immunotherapeutic, and anti-angiographic agents, with limited success. We present a short discussion on CNS HPCs, focusing our discussion on available evidence regarding the role of microsurgical resection, EBRT, SRS, chemotherapy, and immunotherapy for upfront, part of adoptive hybrid surgery approach or for recurrent HPCs.

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Thirty-nine cases of intracranial hemangiopericytoma and anaplastic hemangiopericytoma: A retrospective review of MRI features and pathological findings

Cited by 47 publications

References 6 publications

Magnetic resonance imaging of intracranial hemangiopericytoma and correlation with pathological findings

Magnetic resonance imaging of intracranial hemangiopericytoma and correlation with pathological findings

Hemangiopericytoma of the Cerebellopontine Angle: A Wolf in Sheep's Clothing

Nervous System Hemangiopericytoma

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