Thixotropic property in pharmaceutical formulations

Lee, Chi H.; Moturi, Venkat; Lee, Yugyung

doi:10.1016/j.jconrel.2009.02.013

Cited by 327 publications

(210 citation statements)

References 82 publications

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“…Furthermore, no thixotropy was observed, because there was no decrease in the apparent viscosity of the formulations with time (the upper and lower curves of the rheograms overlap). 26 These data corroborate the results found after the application of the rheological models, where the n-value was less than 1, which indicates a shear thinning behavior. 28,29 From the observation of all rheograms, it can be seen that the HG-NLC showed lower viscosity than the HG, indicating that the presence of lipid nanoparticles influences the consistency of the HG, leading to a decrease in viscosity.…”

supporting

confidence: 88%

“…These studies can be performed in viscometers, and the respective flow behavior can be assessed by analysis of the plots of shear stress versus shear rate. 22,26,27 Nonetheless, the use of mathematical models that fit the rheological data is important to confirm the flow behavior graphically observed. Therefore, two models were applied: 28,29 power law (Ostwald-de Waele), and power law with a yield stress (Herschel-Bulkley).…”

Section: Rheological Measurementsmentioning

confidence: 99%

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Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration

Tichota¹,

Silva²,

Lobo³

et al. 2014

IJN

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Given its advantages in skin application (eg, hydration, antiaging, and protection), argan oil could be used in both dermatological and cosmetic formulations. Therefore, the preparation of nanostructured lipid carriers (NLCs) using argan oil as a liquid lipid is a promising technique, since the former constitute well-established systems for dermal delivery. The aim of this work was to develop a topical formulation of argan oil NLCs to improve skin hydration. Firstly an NLC dispersion was developed and characterized, and afterward an NLC-based hydrogel was prepared. The in vivo evaluation of the suitability of the prepared formulation for the proposed application was assessed in volunteers, by measuring different skin-surface parameters for 1 month. An argan oil NLC-based hydrogel formulation was successfully prepared and characterized. Moreover, the entrapment of the NLCs in the hydrogel net did not affect their colloidal sizes. Additionally, it was observed that this formulation precipitated an increase in skin hydration of healthy volunteers. Therefore, we concluded that the preparation of NLC systems using argan oil as the liquid lipid is a promising strategy, since a synergistic effect on the skin hydration was obtained (ie, NLC occlusion plus argan oil hydration).

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supporting

confidence: 88%

Section: Rheological Measurementsmentioning

confidence: 99%

Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration

Tichota¹,

Silva²,

Lobo³

et al. 2014

IJN

View full text Add to dashboard Cite

show abstract

“…In both cases, the slope of the flow curve is constant, and the graph of viscosity is a line (38,39). The curves for SpIII and SpIV are slightly dependent on shear rate, showing a consistent, although relatively small, decrease in viscosity with increasing shear rate from 0 to 100 s -1 .…”

Section: Physical Stabilitymentioning

confidence: 80%

Development, Physical-Chemical Stability, and Release Studies of Four Alcohol-Free Spironolactone Suspensions for Use in Pediatrics

Bernal¹,

Calpena²,

Mallandrich³

et al. 2014

Dissolution Technol.

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Dissolution studies have become of great significance because, in most cases, drug dissolution is the rate-limiting step in the absorption process. As occurs with solid oral dosage forms, heterogeneous dispersed systems (suspensions) could also have some problems with their in vitro dissolution.The objective of this study was to evaluate the influence of excipients on the release of spironolactone from four alcohol-free suspensions (pharmaceutical compounding) of spironolactone 5 mg/mL suitable for pediatric use.In addition, the comparison of the physical and chemical stability of the suspensions stored at 4, 25, and 40 °C over a 60-day period has been studied. Rheological behavior, particle size, a prediction of long-term physical stability, pH, and assay of spironolactone by HPLC were assessed at preset times. The dissolution profile of each suspension was determined and compared with that of the commercial tablets. A microbiological study of the best formula was also performed. Chemically, the four spironolactone suspensions were stable for 60 days stored at three temperatures; Suspension IV had optimum pH values and the highest recovery percentage. In terms of physical stability, sedimentation occurred in Suspension IV, and flotation of spironolactone occurred in Suspensions I, II, and III. Suspension III had the highest viscosity and the slowest drug release. Suspension IV was also microbiologically stable for 60 days. In conclusion, Suspension IV had the best properties. The least suitable form was Suspension III, as its high viscosity made it difficult to achieve homogeneous redispersion and it had the slowest dissolution profile.

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“…2. Formulation I graph shows constant viscosity values with increasing shear rate from 0 to 100 s −1 with constant slope that gives rise to a line, and thus Newtonian behaviour (Lee et al, 2009). Formulation II curve showed a small dependence on shear rate, showing a consistent, although relatively small, decrease in viscosity with increasing shear rate from 0 to 100 s −1 .…”

Section: Physicochemical Characterization and Stabilitymentioning

confidence: 88%

Design and physicochemical stability studies of paediatric oral formulations of sildenafil

Provenza¹,

Calpena²,

Mallandrich³

et al. 2014

International Journal of Pharmaceutics

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Personalized medicine is a challenging research area in paediatric treatments. Elaborating new paediatric formulations when no commercial forms are available is a common practice in pharmacy laboratories; among these, oral liquid formulations are the most common. But due to the lack of specialized equipment, frequently studies to assure the efficiency and safety of the final medicine cannot be carried out. Thus the purpose of this work was the development, characterization and stability evaluation of two oral formulations of sildenafil for the treatment of neonatal persistent pulmonary hypertension. After the establishment of a standard operating procedure (SOP) and elaboration, the physicochemical stability parameters appearance, pH, particle size, rheological behaviour and drug content of formulations were evaluated at three different temperatures for 90 days. Equally, prediction of long term stability, as well as, microbiological stability was performed. Formulations resulted in a suspension and a solution slightly coloured exhibiting fruity odour. Formulation I (suspension) exhibited the best physicochemical properties including Newtonian behaviour and uniformity of API content above 90% to assure an exact dosification process.

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Thixotropic property in pharmaceutical formulations

Cited by 327 publications

References 82 publications

Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration

Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration

Development, Physical-Chemical Stability, and Release Studies of Four Alcohol-Free Spironolactone Suspensions for Use in Pediatrics

Design and physicochemical stability studies of paediatric oral formulations of sildenafil

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