We investigated the degree of content specificity evident in the negative cognitions associated with anxiety and depression in two large samples of general psychiatric outpatients. Standardized measures of affect and cognition were analyzed in a multiple regression design. As predicted by Beck's (1967Beck's ( ,1976Beck's ( ,1987 cognitive theory of psychopathology, thoughts of loss and failure were specifically associated with depression, whereas cognitions of harm and danger were uniquely predictive of anxiety. In addition, hopelessness was specific to depression and not to anxiety. Dysfunctional beliefs showed no consistent association with either mood state. The implication of these results, as well as related findings, is discussed in terms of a cognitive perspective on the differentiation of emotional disorders. Also discussed are the methodological difficulties encountered in research on cognitiveaffective relationships.Cognitive theories of psychopathology have gained prominence in recent years (Mahoney, 1988). A number of theoretical models have been proposed, each regarding cognitive mediation as crucial to affective and behavioral responding. However, the cognitive constructs used by cognitive-clinical theorists to explain such mediation frequently involve different levels of conceptualization. Recently Ingram and Kendall (1986) suggested that most cognitive variables can be categorized as referring to the structure, proposition, operation, or product of the information-processing system. Structured variables refer to the manner in which information is internally organized (i.e., schemata or associative networks), whereas propositions are the stored contents of these structures. Cognitive operations refer to the processes involved in the interaction of the various components of the information-processing system. Finally, cognitive products are viewed as output resulting from the functioning of the information-processing system (i.e., thoughts and images).Beck 's(1967,1976,1987) cognitive theory (CT) of emotional disorders views cognitive mediation in terms of the interaction of these four components of a faulty information-processing system. At the broadest level, maladaptive functional structures called schemata direct the screening, encoding, organization,