Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea

Abstract

Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2–C-2′ linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC50 values ranging from 13.1 to 29.1 μM.

The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China

“…We found that this fungus contained abundant anthraquinone compounds. Four new anthraquinone and tetrahydroanthraquinone derivatives 1-4, were isolated from this fungus along with seven known compounds (5)(6)(7)(8)(9)(10)(11) (Figure 1). Compound 1, a novel tetrahydroanthraquinone with an epoxy ether bond between C-4a and C-9a, and compound 2, a tetrahydroanthraquinone dimer with a C-4-C-4' linkage, are rare.…”

“…Anthraquinones and tetrahydroanthraquinones are widely distributed as secondary metabolites in natural biosources, and show important biological activities [2][3][4][5]. So far, 18 compounds of alterporriol family [6][7][8][9][10][11][12] and 14 compounds of altersolanol family [9,[13][14][15][16] have been reported. Herein, we report that the isolation, elucidation and biological activities of the anthraquinone and tetrahydroanthraquinone derivatives from Alternaria sp.…”

Secondary Metabolites of a Mangrove Endophytic Fungus Aspergillus terreus (No. GX7-3B) from the South China Sea

“…Marine fungi have been proven to be an important source of structurally novel and bioactive secondary metabolites [1,2,3,4,5], and it is well-known that under various culture conditions, many marine fungi can produce various secondary metabolites, which possess unique structures and bioactivities [6,7]. Aspergillus terreus (No.…”

Fungal Endophytes: An Amazing and Hidden Source of Cytotoxic Compounds

“…ZJ9-6B, isolated from the mangrove Aegiceras corniculatum. Alterporriol K exhibited cytotoxicity against MDA-MB-435 and MCF-7 cells with IC 50 values of 26.97 and 29.11 μM, respectively, and alterporriol L exhibited cytotoxicity against MDA-MB-435 and MCF-7 cells with IC 50 values of 13.11 and 20.04 μM, respectively (Huang et al 2011).…”