Three Cases of Combined Therapy in Primary Breast Lymphoma (PBL) with Successful Outcomes

Inić, Zorka; Inić, M.; Zegarac, M.; Inić, Ivana; Pupić, Gordana

doi:10.4137/cmo.s12044

Cited by 11 publications

(7 citation statements)

References 17 publications

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“…In fact, BL can develop in both gender, but occur more frequently among women (98%) (5,15,(20)(21)(22)(23)(24)(25)(26)(27) and most cases present in the 5 th or 6 th decade of life (3,28). The predominant presenting sign is a painless solitary mass (26) involving mainly the external superior quadrant of the right breast (29,30), although bilateral involvement has been reported in 1-14% of cases (31,32). Signs of nipple or skin involvement are infrequent (14,15,20) and constitutional B symptoms (such as fever, night sweats and weight loss) are rare and usually indicative of disseminated disease (5,21,(25)(26)(27)33).…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and management of breast lymphoma: a single-institution retrospective analysis

Orlandi¹,

Sánchez²,

Calegari³

et al. 2018

Transl. Cancer Res

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Background: Breast lymphoma (BL) is a rare entity. Although mimicking clinical presentation and radiological features of epithelial breast malignancies, prognosis and treatment management are different. Here we report our single institution experience in such population. Methods: The database of our pathology institute was retrospectively searched for breast neoplasms coded as lymphoma from January 2000 to January 2017. The assessed data were: gender, age at diagnosis, laterality, stage (primary or secondary), histopathological diagnosis and grading (high vs. low) treatment, recurrence and survival status. Progression-free survival (PFS), overall survival (OS) and 5-year recurrence rate were estimated. An exploratory analysis comparing survival (PFS, OS and 5-year recurrence rate) between highand low-grade histotypes and primary and secondary stages was performed. Results: Fifteen patients were included in the analysis. All patients were affected by B-cell type lymphomas; the most frequent subtype was diffuse large B-cell lymphoma (DLBCL). Patients affected by high-grade lymphomas were treated with polychemotherapy followed in about half of cases by consolidative ipsilateral breast radiotherapy. Patients affected by low-grade lymphomas were treated with local treatment only (surgical resection +/− radiotherapy). No patient received radical surgery or axillary dissection. At a median follow up of 9 years, four patients had relapsed (all affected by high-grade lymphomas) with central nervous system (CNS) involved in half cases. Both median PFS and OS were not reached, but a slight trend toward a better survival was noticed in favor of primary breast lymphoma (PBL), while a clearer survival benefit was observed in the low-grade cohort. The estimated 5-year survival rate was 77% within the whole population, 78% vs. 66% for primary vs. secondary and 100% vs. 66% for low-grade vs. high-grade BL. Conclusions: Our data concerning clinical and pathological features are consistent with those previously reported. Management of disease was based on histology. Although being a rare disease it is mandatory to take it into account for differential diagnosis since treatment and prognosis differs widely from primary breast malignancies.

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Section: Discussionmentioning

confidence: 99%

Diagnosis and management of breast lymphoma: a single-institution retrospective analysis

Orlandi¹,

Sánchez²,

Calegari³

et al. 2018

Transl. Cancer Res

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“…Unilateral affection of the upper right quadrant of the breast is the most common reported presentation of PBL [5] , [6] , while only 1%-14% of all reported PBL cases have bilateral disease [7] .…”

Section: Discussionmentioning

confidence: 99%

Primary diffuse large B-cell non-Hodgkin's lymphoma of the breast—A case report and review of the literature

Harb

Balata

Ashour

et al. 2019

Radiology Case Reports

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Primary breast lymphoma (PBL) is considered a rare clinical entity forming about 0.4%-0.5% of all breast tumors.In this report we have presented a case of PBL in a 56-year-old female complaining of a mass in the upper medial quadrant of the breast.PBL suspicion of our case was made by breast radiology and the sure diagnosis was reached by the immunohistochemistry results; CD (cluster of differentiation) 20: was diffusely positive; Pan-CK (pan-cytokeratin): was diffusely negative in tumor cells. Hence, the case was finally diagnosed as a primary breast a primary breast diffuse large B-cell non-Hodgkin's lymphoma of lymphoma.The management and outcome of PBL and carcinoma are totally different. Accurate diagnosis of PBL by true cut needle biopsy and immunocytochemistry is important to avoid unnecessary mastectomies.

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“…It is predominantly (95%–100%) reported among female patients and is very rare in males [ 8 ]. Single-breast involvement is more common, particularly in the upper quadrant of the right side [ 9 , 11 ]. Approximately 1% to 14% of all PBL cases have bilateral breast lymphomas [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…The treatment options for PBL vary from surgical intervention to chemotherapy and/or radiotherapy [ 9 ]. Herein, we report a rare case of primary non-Hodgkin lymphoma of the breast, with B-cell phenotype, diagnosed by mammography and computed tomography and confirmed by histopathological examination.…”

Section: Introductionmentioning

confidence: 99%

Primary Breast Lymphoma in a Woman: A Case Report and Review of the Literature

et al. 2016

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Patient: Female, 43Final Diagnosis: Primary breast lymphomaSymptoms: —Medication: —Clinical Procedure: CT scan • PET • chemotherapy • radiotherapySpecialty: OncologyObjective:Rare diseaseBackground:Primary breast lymphoma (PBL) is an unusual clinical entity accounting for 0.4–0.5% of all breast neoplasms. The usual presentation includes a painless palpable mass similar to that of breast carcinoma. Diffuse large B-cell lymphoma (DLBCL) is the most common identifiable type of PBL based on the histopathological examination.Case Report:We report an unusual case of a 43-year-old Indonesian woman who presented with a 7-month history of a painless mass in the left breast. A core needle biopsy revealed diffuse infiltration of large atypical lymphoid cells. The immunohistochemical biomarkers confirmed the diagnosis of a DLBCL. A bone scan showed no evidence of bone metastasis. It was treated non-surgically, based on the decision of the breast multidisciplinary team (MDT). The patient was treated with 4 cycles of combination chemotherapy with R-CODOX/IVAC. A follow-up PET scan revealed non-significant mild F-18 fluorodeoxyglucose (FDG) uptake at the periphery of the residual left breast mass, indicating a radiologically favorable response.Conclusions:Early and accurate diagnosis of PBL is crucial for selecting the appropriate MDT treatment strategies to avert potentially harmful surgical interventions.

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Three Cases of Combined Therapy in Primary Breast Lymphoma (PBL) with Successful Outcomes

Cited by 11 publications

References 17 publications

Diagnosis and management of breast lymphoma: a single-institution retrospective analysis

Diagnosis and management of breast lymphoma: a single-institution retrospective analysis

Primary diffuse large B-cell non-Hodgkin's lymphoma of the breast—A case report and review of the literature

Primary Breast Lymphoma in a Woman: A Case Report and Review of the Literature

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