Three Chinese herbal medicines promote neuroproliferation in vitro, and reverse the effects of chronic mild stress on behavior, the HPA axis, and proliferation of hippocampal precursor cell in vivo

Pao, Li-Heng; Lu, Shao Wei; Sun, Gao; Chiou, Shih Hwa; Hsing, Kuo

doi:10.1016/j.jep.2012.09.002

Cited by 12 publications

(9 citation statements)

References 47 publications

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“…Recent studies have discovered that RC has a noticeable antinociceptive effect on the central dopaminergic system. A remarkable effect of antidepression and sedative activity is also reported in patients treated with RC in different diseases [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Metabonomic Study of the Effect of Dingkundan Intervention Comparing with Oral Contraceptives on Primary Dysmenorrhea Using the UPLC-MS Technique

Cai

Zhang

Ding

et al. 2022

BioMed Research International

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Primary dysmenorrhea (PD) is a prevalent problem in gynecologic clinics among adolescents and women of reproductive age. Several therapy modalities, including traditional Chinese medicine, are deemed adequate (TCM) and have been in practice for a long time. In China, Dingkundan (DKD), a multicomponent gynecological treatment, has been used to treat PD for centuries. However, the fundamental process remains poorly understood. Comparing plasma samples acquired from DKD-treated and oral contraceptive- (OC-) treated subjects, we performed an integrated plasma metabonomic analysis utilizing the UPLC-MS technology to study the therapeutic mechanisms of DKD in PD patients. Thirty possible biomarkers and metabolic pathways were discovered, primarily steroid hormone production, glycerophospholipid metabolism, and bile secretion. The results suggested that DKD may have therapeutic benefits for PD patients via modulation of various metabolic pathways. This study is envisaged to provide detailed metabolite information regarding the etiology of PD, an assessment of the efficacy of DKD, and a comparison of DKD and OC.

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Section: Discussionmentioning

confidence: 99%

Metabonomic Study of the Effect of Dingkundan Intervention Comparing with Oral Contraceptives on Primary Dysmenorrhea Using the UPLC-MS Technique

Cai

Zhang

Ding

et al. 2022

BioMed Research International

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“…in patients with MDD, and antidepressants can partially alleviate this phenomenon (Mahar et al, 2014;Perera et al, 2007). Evidence from animal studies suggests that anti-depressive treatments affect hippocampal neurogenesis in a number of different manners that involve neurotransmitter systems (Mahar et al, 2014), stress-induced activity of the hypothalamic-pituitary-adrenal (HPA) system (Pao et al, 2012), vascular niches (Massouh and Saghatelyan, 2010), nitric oxide synthase-III (Reif et al, 2004), neurotrophins (Tzeng et al, 2014), metabotropic glutamate receptor (Matrisciano et al, 2008) and other mechanisms (Conti and Blendy, 2004). Although many studies have explored the potential mechanisms of hippocampal neurogenesis (Perera et al, 2007), the details of its effects remain to be fully elucidated.…”

Section: Discussionmentioning

confidence: 99%

Quetiapine and repetitive transcranial magnetic stimulation ameliorate depression-like behaviors and up-regulate the proliferation of hippocampal-derived neural stem cells in a rat model of depression: The involvement of the BDNF/ERK signal pathway

Chen

Zhang

Xue

et al. 2015

Pharmacology Biochemistry and Behavior

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“…In the stressed state, peptides in the SAE may supplement the body nutritionally and regulate the imbalance of neurotransmitters, which would inhibit the development of ulcers or delay formation (Zhao et al, ). 5‐HT is a monoamine neurotransmitter that plays a critical role in emotional control and maintaining mental balance (Pao, Lu, Sun, Chiou, & Ma, ; Wang et al, ). NE has been implicated in the formation of stress ulcers (Morilak et al, , Garabadu et al, ).…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective effect of the protease-rich extract from sheep abomasum against stress-induced gastric ulcers in rats

et al. 2018

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In this study, ultrasound‐assisted extraction method (UAE) was developed to obtain the protease‐rich extract from sheep abomasum (SAE). UAE parameters were first optimized using response surface methodology. Ultrasonic time of 18 min, ultrasonic power of 260 W, and a liquid/solid ratio of 22 mL/g resulted in the highest proteolytic activity and yield of the SAE (4,951.3 U/g, 14.3%, respectively). Then we investigated SAE's gastroprotective effect against gastric ulcers induced by water immersion‐restraint stress in rats. After 7 days of intragastric administration of the SAE (0.2 g/kg/day), the ulcer index (2.71 ± 0.97; p < .05) decreased significantly compared with that in the model group, and the ulcer inhibition ratio was 66.5%. In addition, the response to stress was significantly attenuated by balancing the levels of norepinephrine, 5‐hydroxytryptamine, and dopamine in brain regions. Practical applications Sheep abomasum is the main waste of the sheep meat industry. Converting those wastes to value‐added products would be beneficial for both environment and economy. Results of this study presented that UAE resulted in a higher proteolytic activity and yield of SAE with a shorter extraction time than the conventional extraction method. The SAE obtained in this study may be a promising agent for prophylaxis and treatment of stress‐induced ulcers.

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Three Chinese herbal medicines promote neuroproliferation in vitro, and reverse the effects of chronic mild stress on behavior, the HPA axis, and proliferation of hippocampal precursor cell in vivo

Cited by 12 publications

References 47 publications

Metabonomic Study of the Effect of Dingkundan Intervention Comparing with Oral Contraceptives on Primary Dysmenorrhea Using the UPLC-MS Technique

Metabonomic Study of the Effect of Dingkundan Intervention Comparing with Oral Contraceptives on Primary Dysmenorrhea Using the UPLC-MS Technique

Quetiapine and repetitive transcranial magnetic stimulation ameliorate depression-like behaviors and up-regulate the proliferation of hippocampal-derived neural stem cells in a rat model of depression: The involvement of the BDNF/ERK signal pathway

Gastroprotective effect of the protease-rich extract from sheep abomasum against stress-induced gastric ulcers in rats

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