Three-component coupling reaction of white phosphorus, alcohols and diaryl disulfides: a chlorine-free avenue for accessing phosphorothioates

Abstract

Synthesis of valuable compounds directly from small and simple molecules is an area of great interest in chemical research.

Synthesis of unsymmetric phosphorotrithioates by sequential coupling of 1,1-dichloro-N,N-diethylphosphanamine with thiols and sulfenyl chloride

“…This versatile cohort of compounds holds promise not only in the context of addressing pragmatic hurdles but also in augmenting our comprehension of chemical synthesis and its overarching implications spanning industries and scientific domains. 4–9 Leveraging the distinctive reactivity of the hydrolyzable P–O bond, phosphorothioates have been harnessed as fluorogenic substrates to illuminate various biological mechanisms. 10 Consequently, the pursuit of adept methods for the synthesis of phosphorothioates stands as a significant focal point in the realm of phosphorus chemistry.…”