To intercept the great maneuvering target, combining with the sliding mode and the extended disturbance observer, a new control algorithm for integrated guidance and control (IGC) system is proposed in this paper. Firstly, the paper formulates the Missile–Target problem. Then the paper establishes an uncertain IGC dynamic model where the nonlinearities, the perturbations and the maneuvering of the target are regarded as disturbance. Secondly, a second-order disturbance observer is designed to estimate the disturbance and their derivatives.. After this, combining with the second-order disturbance observer, a modified sliding surface and the corresponding reaching law are designed to obtain the rudder deflection command directly. Thus, the real sense of IGC system is achieved. Next, the paper uses the Lyapunov stability theory to prove the stability of the system. Finally, the paper provides different simulation cases, which have different maneuver modes of the target, to demonstrate the superiority of the proposed method in reducing the response time, increasing the rudder response, and having a high interception probability.