Three-dimensional analysis of lipid vesicle transformations

Sakashita, Ai; Urakami, Naohito; Ziherl, P.; Imai, Masayuki

doi:10.1039/c2sm25759a

Cited by 68 publications

(88 citation statements)

References 34 publications

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“…These various shape transformations can be well described using the elastic theory proposed by Helfrich [1,2]. The theoretical prediction agrees well with experiments quantitatively [3].…”

Section: Introductionsupporting

confidence: 72%

Bilayer sheet protrusions and budding from bilayer membranes induced by hydrolysis and condensation reactions

Nakagawa

Noguchi

2018

Soft Matter

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Shape transformations of flat bilayer membranes and vesicles induced by hydrolysis and condensation reactions of amphiphilic molecules are studied using coarse-grained molecular dynamics simulations. The hydrolysis and condensation reactions result in the formation and dissociation of amphiphilic molecules, respectively. Asymmetric reactions between the inner and outer leaflets of a vesicle can transport amphiphilic molecules between the leaflets. It is found that the resulting area difference between the two leaflets induces bilayer sheet protrusion (BP) and budding at low reduced volumes of the vesicles, whereas BP only occurs at high reduced volumes. The probabilities of these two types of transformations depend on the shear viscosity of the surrounding fluids compared to the membrane as well as the reaction rates. A higher surrounding fluid viscosity leads to more BP formation. The inhomogeneous spatial distribution of the hydrophobic reaction products forms the nuclei of BP formation, and faster diffusion of the products enhances BP formation. Our results suggest that adjustment of the viscosity is important to control membrane shape transformations in experiments.

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“…These various shape transformations can be well described using the elastic theory proposed by Helfrich [1,2]. The theoretical prediction agrees well with experiments quantitatively [3].…”

Section: Introductionsupporting

confidence: 72%

Bilayer sheet protrusions and budding from bilayer membranes induced by hydrolysis and condensation reactions

Nakagawa

Noguchi

2018

Soft Matter

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“…These are universal membrane morphologies that can be modelled by considering the reduction in vesicle volume versus the reduction of monolayer area difference between the two leaflets (area-difference-elasticity theory) [38],[39]. Under specific environmental conditions, vesicles composed only of lipids can also form tubes favoured, for example, by specific lipid compositions [40],[41].…”

Section: Discussionmentioning

confidence: 99%

Mechanism of Membranous Tunnelling Nanotube Formation in Viral Genome Delivery

et al. 2013

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“…This is area-difference elasticity (ADE) model, which degenerates to the minimal, SC or BC model as a special case. The ADE model has been validated experimentally on vesicles [21,22].…”

Section: Introductionmentioning

confidence: 99%

Bending models of lipid bilayer membranes: Spontaneous curvature and area-difference elasticity

Bian

Litvinov

Koumoutsakos

2020

Computer Methods in Applied Mechanics and Engineering

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We preset a computational study of bending models for the curvature elasticity of lipid bilayer membranes that are relevant for simulations of vesicles and red blood cells. We compute bending energy and forces on triangulated meshes and evaluate and extend four well established schemes for their approximation: Kantor and Nelson [1], Jülicher [2], Gompper and Kroll [3] and Meyer et. al. [4], termed A, B, C, D. We present a comparative study of these four schemes on the minimal bending model and propose extensions for schemes B, C and D. These extensions incorporate the reference state and non-local energy to account for the spontaneous curvature, bilayer coupling, and area-difference elasticity models. Our results indicate that the proposed extensions enhance the models to account for shape transformation including budding/vesiculation as well as for non-axisymmetric shapes. We find that the extended scheme B is superior to the rest in terms of accuracy, and robustness as well as simplicity of implementation. We demonstrate the capabilities of this scheme on several benchmark problems including the budding-vesiculating process and the reproduction of the phase diagram of vesicles.

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Three-dimensional analysis of lipid vesicle transformations

Cited by 68 publications

References 34 publications

Bilayer sheet protrusions and budding from bilayer membranes induced by hydrolysis and condensation reactions

Bilayer sheet protrusions and budding from bilayer membranes induced by hydrolysis and condensation reactions

Mechanism of Membranous Tunnelling Nanotube Formation in Viral Genome Delivery

Bending models of lipid bilayer membranes: Spontaneous curvature and area-difference elasticity

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