Abstract:Graphitic
carbon nitride (g-C3N4) as a metal-free
nanozyme has attracted huge attention for catalytic applications.
However, the catalytic activity of pure g-C3N4 causes very moderate H2O2 activation. Herein,
a novel three-dimensional (3D) branched carbon nitride nanoneedle
(3DBC-C3N4) nanozyme has been proposed to overcome
such shortcoming. This unique 3D branched structure of 3DBC-C3N4 facilitated effective mass transfer during catalytic
reaction and induced a lightning rodlike effect to accelerate electron
… Show more
“…In addition, nanozymes' activity is strongly dependent on the availability and reactivity of surface-active sites and electron transport properties. 15 To this end, surface engineering to proliferate catalytic active sites and enhance electron transfer activity along with facile and economic synthesis is essential to boost the catalytic efficiency over a broad range of pHs, which can open this field to valuable advancements in the future. In this context, carbon quantum dots (CQDs) with the features of a nanocrystalline core and a conjugated π-system have become ideal candidates to be employed as enzyme mimetic owing to excellent electron transfer ability, 18,19 unique optical and physicochemical properties.…”
Section: Introductionmentioning
confidence: 99%
“…To resolve these limitations, enzyme-mimicking nanomaterials, so-called “nanozymes,” with remarkable performance have recently been designed and developed. Diverse metal, or carbon-based nanostructures, − including Pt nanoclusters, Cu 2+ -functionalized carbon nitride nanoparticles, carboxyl-functionalized graphene oxide (GO–COOH), hemin-functionalized WS 2 nanosheets, silica-supported Au nanoparticles (NPs), Ni–Pd hollow nanoparticles, Co 3 O 4 NPs, (BiO) 2 CO 3 composites, and V 2 O 5 nanowires, have been reported to mimic the complexity and functions of native enzymes. , The unique and inherent characteristics of nanozymes, such as large surface area and high density of active sites, are considerably advantageous for achieving significant enzyme mimetic activity in practical applications . Unlike natural enzymes, nanozymes offer various beneficial properties, such as flexibility in composition and structural design, less consumption, have tunable catalytic activity, economic synthesis, and robustness to denaturation …”
Section: Introductionmentioning
confidence: 99%
“…However, until now, the practical utilization of peroxidase-mimicking nanozymes has been limited by the incorporation of noble metal NPs, such as Pt and Au, for achieving high catalytic activity, complicated and time-consuming synthetic protocols, aggregation of nanozymes, low water solubility, and limited activity only present in acidic pH conditions. In addition, nanozymes’ activity is strongly dependent on the availability and reactivity of surface-active sites and electron transport properties . To this end, surface engineering to proliferate catalytic active sites and enhance electron transfer activity along with facile and economic synthesis is essential to boost the catalytic efficiency over a broad range of pHs, which can open this field to valuable advancements in the future.…”
Nanozymes
have drawn significant scientific interest due to their
high practical importance in terms of overcoming the instability,
complicated synthesis, and high cost of protein enzymes. However,
their activity is generally limited to particular pHs, especially
acidic ones. Herein, we report that luminescent N, S, and P-co-doped
carbon quantum dots (NSP-CQDs) act as attractive peroxidase mimetics
in a wide pH range, even at neutral pH, for the peroxidase substrate
2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS)
in the presence of H2O2. The synergistic effects
of multiple heteroatoms doping in CQDs boost the catalytic activity
in a wide pH range attributed to the presence of high density of active
sites for enzymatic-like catalysis and accelerated electron transfer
during the peroxidase-like reactions. A possible reaction mechanism
for the peroxidase-like activity of CQDs is investigated based on
the radical trapping experiments. Moreover, the multifunctional activity
of NSP-CQDs was further utilized for antibacterial assays for both
Gram-negative and Gram-positive model species, including Escherichia
coli (E. coli) and Staphylococcus
aureus (S. aureus), respectively. The growths
of the employed E. coli and S. aureus were found to be significantly inhibited due to the peroxidase-mediated
perturbation of cell walls. The present work signifies the current
advance in the rational design of N, S, and P-co-doped CQDs as highly
active peroxidase mimics for novel applications in diverse fields,
including catalysis, medical diagnostics, environmental chemistry,
and biotechnology.
“…In addition, nanozymes' activity is strongly dependent on the availability and reactivity of surface-active sites and electron transport properties. 15 To this end, surface engineering to proliferate catalytic active sites and enhance electron transfer activity along with facile and economic synthesis is essential to boost the catalytic efficiency over a broad range of pHs, which can open this field to valuable advancements in the future. In this context, carbon quantum dots (CQDs) with the features of a nanocrystalline core and a conjugated π-system have become ideal candidates to be employed as enzyme mimetic owing to excellent electron transfer ability, 18,19 unique optical and physicochemical properties.…”
Section: Introductionmentioning
confidence: 99%
“…To resolve these limitations, enzyme-mimicking nanomaterials, so-called “nanozymes,” with remarkable performance have recently been designed and developed. Diverse metal, or carbon-based nanostructures, − including Pt nanoclusters, Cu 2+ -functionalized carbon nitride nanoparticles, carboxyl-functionalized graphene oxide (GO–COOH), hemin-functionalized WS 2 nanosheets, silica-supported Au nanoparticles (NPs), Ni–Pd hollow nanoparticles, Co 3 O 4 NPs, (BiO) 2 CO 3 composites, and V 2 O 5 nanowires, have been reported to mimic the complexity and functions of native enzymes. , The unique and inherent characteristics of nanozymes, such as large surface area and high density of active sites, are considerably advantageous for achieving significant enzyme mimetic activity in practical applications . Unlike natural enzymes, nanozymes offer various beneficial properties, such as flexibility in composition and structural design, less consumption, have tunable catalytic activity, economic synthesis, and robustness to denaturation …”
Section: Introductionmentioning
confidence: 99%
“…However, until now, the practical utilization of peroxidase-mimicking nanozymes has been limited by the incorporation of noble metal NPs, such as Pt and Au, for achieving high catalytic activity, complicated and time-consuming synthetic protocols, aggregation of nanozymes, low water solubility, and limited activity only present in acidic pH conditions. In addition, nanozymes’ activity is strongly dependent on the availability and reactivity of surface-active sites and electron transport properties . To this end, surface engineering to proliferate catalytic active sites and enhance electron transfer activity along with facile and economic synthesis is essential to boost the catalytic efficiency over a broad range of pHs, which can open this field to valuable advancements in the future.…”
Nanozymes
have drawn significant scientific interest due to their
high practical importance in terms of overcoming the instability,
complicated synthesis, and high cost of protein enzymes. However,
their activity is generally limited to particular pHs, especially
acidic ones. Herein, we report that luminescent N, S, and P-co-doped
carbon quantum dots (NSP-CQDs) act as attractive peroxidase mimetics
in a wide pH range, even at neutral pH, for the peroxidase substrate
2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS)
in the presence of H2O2. The synergistic effects
of multiple heteroatoms doping in CQDs boost the catalytic activity
in a wide pH range attributed to the presence of high density of active
sites for enzymatic-like catalysis and accelerated electron transfer
during the peroxidase-like reactions. A possible reaction mechanism
for the peroxidase-like activity of CQDs is investigated based on
the radical trapping experiments. Moreover, the multifunctional activity
of NSP-CQDs was further utilized for antibacterial assays for both
Gram-negative and Gram-positive model species, including Escherichia
coli (E. coli) and Staphylococcus
aureus (S. aureus), respectively. The growths
of the employed E. coli and S. aureus were found to be significantly inhibited due to the peroxidase-mediated
perturbation of cell walls. The present work signifies the current
advance in the rational design of N, S, and P-co-doped CQDs as highly
active peroxidase mimics for novel applications in diverse fields,
including catalysis, medical diagnostics, environmental chemistry,
and biotechnology.
“…10A,B, water contact angle (CA) of BiVO 4 (69.55°) and A-FeOOH/BiVO 4 (8 wt%) (48.35°) was measured. This result meant that the covered amorphous FeOOH made BiVO 4 possess water favorable wetting capacity, providing a good chance to oxidate H 2 O in aqueous environment 60 .Figure 10Water contact angle of ( A ) BiVO 4 and ( B ) A-FeOOH/BiVO 4 (8 wt%).…”
A novel amorphous FeOOH modified BiVO4 photocatalyst (A-FeOOH/BiVO4) was successfully produced and characterized by various techniques. The results showed that amorphous FeOOH with about 2 nm thickness evenly covered on BiVO4 surface, which caused resultant A-FeOOH/BiVO4 exhibiting higher visible light photocatalytic performance for producing O2 from water than BiVO4. When the covered amount of amorphous FeOOH was 8%, the resultant photocatalyst possessed the best photocatalytic performance. To find the reasons for the improvement of photocatalytic property, electrochemical experiments, DRS, PL and BET, were also measured, the experimental results indicated that interface effect between amorphous FeOOH and BiVO4 could conduce to migration of photogenerated charge, and exhibit stronger light responded capacity. These positive factors promoted A-FeOOH/BiVO4 presenting improved the photocatalytic performance. In a word, the combination of amorphous FeOOH with BiVO4 is an effective strategy to conquer important challenges in photocatalysis field.
“…In addition, aptamers are also used in homogenous assays which do not need to separate or wash because they bind to the target directly in a sequence-specific manner [23][24][25]. Recently, nucleic acid aptamers have been used widely as affinity receptors in combination with various signal transduction strategies based on nanomaterials in different kinds of biosensing platforms, including colorimetry, chemiluminometry, electrochemistry, fluorometry, and fluorescence anisotropy [26][27][28][29][30][31]. The aptamer-based biosensors have high detection sensitivity because aptamer can easily integrate with the signal amplification strategies, such as rolling circle amplification, CRISPR technology, PCR technology, LAMP technology, and magnetic separation technology.…”
Sepsis, the syndrome of infection complicated by acute organ dysfunction, is a serious and growing global problem, which not only leads to enormous economic losses but also becomes one of the leading causes of mortality in the intensive care unit. The detection of sepsis-related pathogens and biomarkers in the early stage plays a critical role in selecting appropriate antibiotics or other drugs, thereby preventing the emergence of dangerous phases and saving human lives. There are numerous demerits in conventional detection strategies, such as high cost, low efficiency, as well as lacking of sensitivity and selectivity. Recently, the aptamer-based biosensor is an emerging strategy for reasonable sepsis diagnosis because of its accessibility, rapidity, and stability. In this review, we first introduce the screening of suitable aptamer. Further, recent advances of aptamer-based biosensors in the detection of bacteria and biomarkers for the diagnosis of sepsis are summarized. Finally, the review proposes a brief forecast of challenges and future directions with highly promising aptamer-based biosensors.
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