Three-dimensional cellulose-hydroxyapatite nanocomposite enriched with dexamethasone loaded metal–organic framework: a local drug delivery system for bone tissue engineering

Sarkar, Chandrani; Chowdhuri, Angshuman Ray; Garai, Subhadra; Chakraborty, Jayanta; Sahu, Sumanta Kumar

doi:10.1007/s10570-019-02618-3

Cited by 48 publications

(27 citation statements)

References 61 publications

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“…[ 30–35 ] Researches in understanding the biological effect of ZIF‐8 in bone tissue engineering have focused on drug delivery of therapeutic agents in hosts for bone‐related disease treatment and surface modification of orthopedic implants. [ 36–40 ] To date, our recent efforts on ZIF‐8 have led to nanoscale ZIF‐8 crystals on porous titanium with a crystal size of 200–300 nm that is endowed with excellent cytocompatibility, osteogenic activity, and biodegradability. As Zn 2+ ions were slowly released from the titanium surface without a burst‐release effect, ZIF‐8 crystals could be gradually degraded under biological conditions.…”

Section: Introductionmentioning

confidence: 99%

Accelerated Bone Regeneration by MOF Modified Multifunctional Membranes through Enhancement of Osteogenic and Angiogenic Performance

Xue

Zhu

Zhang

et al. 2021

Adv Healthcare Materials

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Owing to the insufficient guidance of new bone formation in orthopedic and craniomaxillofacial surgery, construction of a guided bone regeneration membrane to support vascularized bone regeneration remains a challenge. Herein, an electrospun asymmetric double‐layer polycaprolactone/collagen (PCL/Col) membrane modified by metal–organic framework (MOF) crystals is developed. The optimization of the PCL/Col weight ratio (1:1 and 1:1.5) enables the composite membrane with a balanced tensile strength (only fell by 49.9% in wet conditions) and a controlled degradation rate (completely degraded at 12 weeks). The MOF crystals can provide a pH‐responsive release of Zn2+ ions. In vitro experiments indicate that the barrier layer functions to prevent the infiltration of fibrous connective tissue. The MOF crystal layer functions to enhance osteogenesis and angiogenesis in vitro. Using a rat calvarial defect model, the MOF crystals exhibit a sign of osteoinductivity along with blood vessel formation after 8 weeks post‐surgery. Strikingly, when assessed in a chick chorioallantoic membrane model, the MOF modified membrane demonstrates a significant angiogenic response, which can be envisaged as its outstanding merits over the commercially Col membrane. Therefore, the MOF crystals represent an exciting biomaterial option, with neovascularization capacity for bone tissue engineering and regenerative medicine.

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Section: Introductionmentioning

confidence: 99%

Accelerated Bone Regeneration by MOF Modified Multifunctional Membranes through Enhancement of Osteogenic and Angiogenic Performance

Xue

Zhu

Zhang

et al. 2021

Adv Healthcare Materials

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“…ZIF-8 can be engineered to acquire bioactivity beyond that of zinc ions through encapsulation of drugs. Admixtures of Dexamethasone ( Sarkar et al, 2019 ) or non-steroidal anti-inflammatory drugs ( Ho et al, 2020 ) to these precursor mixtures during precipitation reactions led to their firm entrapment within ZIF-8. ZIF-8 shows a sustained release behavior for small molecules up to several weeks ( Liédana et al, 2012 ).…”

Section: Preparation Methods Of Mofs Suitable For Term Laboratories Amentioning

confidence: 99%

Metal-Organic Framework (MOF)-Based Biomaterials for Tissue Engineering and Regenerative Medicine

Shyngys

Ren

Xiao-qi

et al. 2021

Front. Bioeng. Biotechnol.

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The synthesis of Metal-organic Frameworks (MOFs) and their evaluation for various applications is one of the largest research areas within materials sciences and chemistry. Here, the use of MOFs in biomaterials and implants is summarized as narrative review addressing primarely the Tissue Engineering and Regenerative Medicine (TERM) community. Focus is given on MOFs as bioactive component to aid tissue engineering and to augment clinically established or future therapies in regenerative medicine. A summary of synthesis methods suitable for TERM laboratories and key properties of MOFs relevant to biomaterials is provided. The use of MOFs is categorized according to their targeted organ (bone, cardio-vascular, skin and nervous tissue) and whether the MOFs are used as intrinsically bioactive material or as drug delivery vehicle. Further distinction between in vitro and in vivo studies provides a clear assessment of literature on the current progress of MOF based biomaterials. Although the present review is narrative in nature, systematic literature analysis has been performed, allowing a concise overview of this emerging research direction till the point of writing. While a number of excellent studies have been published, future studies will need to clearly highlight the safety and added value of MOFs compared to established materials for clinical TERM applications. The scope of the present review is clearly delimited from the general ‘biomedical application’ of MOFs that focuses mainly on drug delivery or diagnostic applications not involving aspects of tissue healing or better implant integration.

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“…The same MOF was loaded with dexamethasone (Dex) and used to prepare a cellulose‐hydroxyapatite nanocomposite [76] . The material had a compressive strength of 16.3±1.57 MPa, a compressive modulus of 0.54 ± 0.073 GPa, and an excellent sustained release profile for dexamethasone during approximately 4 weeks (PBS pH 7.4), in contrast with the rate of 2 weeks observed for Dex@ZIF‐8.…”

Section: Manufacturing Delivery Hybrid Biomaterials Based On Coordinamentioning

confidence: 99%

Bone Tissue Disorders: Healing Through Coordination Chemistry

Barbosa

Mendes

Figueira

et al. 2020

Chemistry A European J

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Osteoporosis, Paget's disease and osteosarcoma are a few examples of bone tissue disorders that affect millions of people worldwide. These conditions can strictly limit the lifestyle of patients and may even lead to their demise. To prevent this or, at least, try to manage the situation, there are several treatments available on the market. Notwithstanding, research has been driven by the possibility to improve the existing therapies, as well as to find new approaches that could better respond to these diseases. In this Review the path is shown through which, in recent years, coordination compounds have been prepared and manufactured to be applied in the management of bone tissue disorders. Starting with the design and preparation of the coordination compounds with various dimensionalities, two approaches have been used: (1) they are prepared as three‐dimensional cages that can act as delivery systems for therapeutic substances, or (2) they are constructed/prepared from compounds with intrinsic therapeutic properties. Following this, several strategies have been explored to manufacture the effective delivery to the patients. The versatility of coordination compounds has allowed their use in the preparation of drug tablets, coatings for titanium implants, or even scaffolds for bone tissue engineering. In the end, it becomes clear that these compounds can be a valuable approach to reach a better treatment for bone tissue disorders. Nonetheless, along the road, a few bumps have appeared concerning the therapeutic profile, such as the effect of the structural arrangement or particle size.

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Three-dimensional cellulose-hydroxyapatite nanocomposite enriched with dexamethasone loaded metal–organic framework: a local drug delivery system for bone tissue engineering

Cited by 48 publications

References 61 publications

Accelerated Bone Regeneration by MOF Modified Multifunctional Membranes through Enhancement of Osteogenic and Angiogenic Performance

Accelerated Bone Regeneration by MOF Modified Multifunctional Membranes through Enhancement of Osteogenic and Angiogenic Performance

Metal-Organic Framework (MOF)-Based Biomaterials for Tissue Engineering and Regenerative Medicine

Bone Tissue Disorders: Healing Through Coordination Chemistry

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