Three-dimensional conformal radiotherapy (3D-CRT) versus intensity modulated radiation therapy (IMRT) in squamous cell carcinoma of the head and neck: A randomized controlled trial

Gupta, Tejpal; Agarwal, Jitendra; Jain, Sandeep; Phurailatpam, Reena; Kannan, Sadhana; Ghosh‐Laskar, Sarbani; Murthy, Vedang; Budrukkar, Ashwini; Dinshaw, Ketayun A.; Prabhash, Kumar; Chaturvedi, Pankaj; D’Cruz, Anil

doi:10.1016/j.radonc.2012.07.001

Cited by 276 publications

(253 citation statements)

References 24 publications

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“…Intensitymodulated radiotherapy (IMRT) for head and neck cancer can spare PGs, leading to significant reductions in the incidence and severity of xerostomia, at a mean dose to PGs of approximately 26 Gy (11)(12)(13)(14)(15). Moreover, salivary function tends to recover within 2 years of IMRT if the mean dose to the PG is 30 Gy or less (12).…”

Section: Discussionmentioning

confidence: 99%

Analysis of Factors Associated with Weight Loss After Esophagectomy for Esophageal Cancer

Kitagawa

Namikawa

Munekage

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Analysis of Factors Associated with Weight Loss After Esophagectomy for Esophageal Cancer

Kitagawa

Namikawa

Munekage

et al. 2016

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“…Cette technique présente trois avantages : la dose de rayons est concentrée préférentiellement sur le volume tumoral, les tissus et les organes voisins sains du cancer sont en grande partie épargnés, les tumeurs de forme complexe deviennent plus facilement traitables [20]. L'IMRT diminue d'une part les effets secondaires liés à la radiothérapie des cancers des VADS comme la xérostomie et l'hyposialie [21,22] : elle contribue donc à améliorer la qualité de vie des patients [21,22]. D'autre part, le risque de récidive de la tumeur serait réduit.…”

Section: Sécrétion Salivaire Et Pouvoir Tamponunclassified

Évaluation quantitative de la secrétion et du pouvoir tampon de la salive au cours de la radiothérapie des cancers des voies aéro-digestives supérieures au Sénégal

Lecor

Dia-Tine

Gaye

et al. 2013

Med Buccale Chir Buccale

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Résumé -Introduction. La radiothérapie, ou utilisation des rayonnements ionisants pour détruire le tissu cancé-reux, représente un des traitements de base pour les cancers des voies aéro-digestives (VADS). Elle doit détruire les cellules cancéreuses, tout en épargnant au mieux les organes ou tissus sains avoisinants. L'objectif de cette étude était d'évaluer les effets de la radiothérapie sur la fonction des glandes salivaires chez des patients traités pour un cancer des VADS. Matériel et méthodes. Une étude transversale descriptive a été réalisée sur 33 patients atteints d'un cancer des VADS et traités dans le service de radiothérapie de l'Hôpital Aristide Le Dantec de Dakar (Sénégal). La xérostomie, les débits salivaires non stimulé et stimulé ainsi que le pH salivaire ont été évalués, avant (T0), pendant (T), et un mois après la fin de la radiothérapie (T1). Les données ont été statistiquement analysées et exploitées en utilisant le logiciel SPSS. Résultats. L'âge des patients variait de 18 à 69 ans. Les patients ayant plus de 60 ans représentaient 45,5 % de la population étudiée. Les hommes constituaient la majorité de l'échantillon (54,5 %). Avant la radiothérapie, aucun signe de xérostomie n'a été observé chez les patients : tous avaient un débit salivaire normal. Pendant les séances de radiothérapie, tous les patients se sont plaints de sécheresse buccale : 19 avaient une hyposialie modérée et 13 avaient une hyposialie sévère. La xérostomie et l'hyposialie sévère ou modérée étaient statistiquement associées à la dose de radiothérapie (p < 0,005). À T0, tous les patients avaient un pH neutre. À T1, 28/33 patients avaient un pH salivaire inférieur à 5,5, évoquant une hyposialie. Conclusion. L'orientation vers de nouvelles techniques d'irradiation de la tête et du cou pour épargner partiellement les glandes salivaires ouvre des voies potentielles de recherche et d'innovation pour les années à venir.Abstract -Quantitative evaluation of the secretion and buffer capacity of saliva during radiotherapy for cancers of the upper aerodigestive tract in Senegal. Introduction. Radiation therapy is a common treatment for head and neck cancers, which uses ionizing radiation, to destroy cancerous tissue. Its purpose is the sterilization of cancer cells while sparing the best surrounding healthy tissue or organs. The objective of this study was to evaluate the effects of radiotherapy on salivary gland function in patients treated for head and neck cancer. Material and methods. A descriptive cross-sectional study was performed repeatedly in 33 patients with head and neck cancer and treated with radiotherapy department of the Aristide Le Dantec Hospital in Dakar (Senegal). Xerostomia, salivary flow unstimulated and stimulated saliva and pH were measured before (T0), during (T), and one month after radiotherapy (T1). The data were statistically analyzed and evaluated using the SPSS software. Results. The extreme age of patients was 18 and 69 years. People over 60 years old accounted for 45.5% of the population. Men constitut...

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“…The main purpose of developing the multileaf collimator is to achieve conformal radiotherapy, which accurately illuminates the lesion target [2]. The radiotherapy system addresses the following main problems: medical image segmentation, medical volume data structure based on body tissue contour, three-dimensional surface reconstruction algorithm based on medical volume data, three-dimensional dose calculation model, and the system control of multileaf collimator [3].…”

Section: Introductionmentioning

confidence: 99%

Design and Parameters Optimization of the Fractional Order Anti-windup Controller for Multileaf Collimator

Zhang¹,

Li²,

Dang³

et al. 2017

JESTR

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During the conformal radiotherapy, the multileaf collimator is usually used to block radiation to avoid the radiation in the normal tissue around the tumor for precise irradiation in target areas. However, there are several shortcomings in the ability of rapidity and anti-interference of precise leaf control in terms of the traditional controllers of leaf position for multileaf collimator. To ensure the rapidity of leaf position in place for short treatment time, a design method of controller of leaf position for multileaf collimator has been proposed, which can keep the leaves in place with short time as well as high accuracy. First, the motor that drives the leaf movement of multileaf collimator was taken as the controlled object, and the corresponding motor model was established. Second, the design method of the fractional order anti-windup controller of leaf position was proposed according to the controlled object. Finally, using quantum-behaved particle swarm optimization (QPSO) to ensure the accuracy of leaf position for multileaf collimator in place, the parameters of the controller of leaf position for multileaf collimator were optimized. The simulation results show that the rising and settling time of the output response of the leaf drive unit is 1.31s in the controller of leaf position for multileaf collimator using the proposed design method, which is better than the 6.4s in the proportional integral differential (PID) algorithm based on the particle swarm optimization (PSO) and the 12.55s in the fuzzy PID algorithm respectively. While the parameter tuning of the controller of leaf position for multileaf collimator is performed by the QPSO algorithm, the required iteration number is less. In addition, after adding the interference, the proposed controller can make the system recover to the much more stable operation state with a stronger ability of anti-interference. The proposed method provides great reference value for the research on the precise leaf position of multileaf collimator and the cooperation control strategy in the later stage.

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Three-dimensional conformal radiotherapy (3D-CRT) versus intensity modulated radiation therapy (IMRT) in squamous cell carcinoma of the head and neck: A randomized controlled trial

Cited by 276 publications

References 24 publications

Analysis of Factors Associated with Weight Loss After Esophagectomy for Esophageal Cancer

Analysis of Factors Associated with Weight Loss After Esophagectomy for Esophageal Cancer

Évaluation quantitative de la secrétion et du pouvoir tampon de la salive au cours de la radiothérapie des cancers des voies aéro-digestives supérieures au Sénégal

Design and Parameters Optimization of the Fractional Order Anti-windup Controller for Multileaf Collimator

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