Three-Dimensional Cotton-Wool-Like Polyhydroxybutyrate/Siloxane-Doped Vaterite Composite Fibrous Scaffolds: Effect of Imogolite-Coating on Physicochemical and Cell Adhesion Properties

Obata, Akiko; Mori, Kazuma; Inukai, Keiichi; Kato, Katsuya; Poologasundarampillai, Gowsihan; Kasuga, Toshihiro

doi:10.3389/fmats.2020.00033

Cited by 3 publications

(2 citation statements)

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“…Cell attachment to the scaffold is directly proportional to the surface roughness of the nanobiomaterial. In the case of electrospun fibers, though the inner surface is extremely rough, the outer surface may not possess this property [ 58 , 59 ]. This explains the increased bioactivity and spurt in bone growth with the β-TCP/PLLA/PGA group that occurred following initial degradation in week 4 compared to week 2.…”

Section: Discussionmentioning

confidence: 99%

“…This explains the increased bioactivity and spurt in bone growth with the β-TCP/PLLA/PGA group that occurred following initial degradation in week 4 compared to week 2. Surface coating has been shown to improve attachment and hydrophilicity to enable better outcomes [ 59 ]. β-TCP has a highly rough surface and allows easy cell proliferation [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

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In Vivo Evaluation of Bone Regenerative Capacity of the Novel Nanobiomaterial: β-Tricalcium Phosphate Polylactic Acid-co-Glycolide (β-TCP/PLLA/PGA) for Use in Maxillofacial Bone Defects

Ramanathan,

Shijirbold,

Okui

et al. 2023

Nanomaterials

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Maxillofacial bone defects are treated by autografting or filling with synthetic materials in various forms and shapes. Electrospun nanobiomaterials are becoming popular due to their easy placement and handling; combining ideal biomaterials extrapolates better outcomes. We used a novel electrospun cotton-like fiber made from two time-tested bioresorbable materials, β-TCP and PLLA/PGA, to check the feasibility of its application to maxillofacial bone defects through an in vivo rat mandibular bone defect model. Novel β-TCP/PLLA/PGA and pure β-TCP blocks were evaluated for new bone regeneration through assessment of bone volume, inner defect diameter reduction, and bone mineral density. Bioactive/osteoconductivity was checked by scoring the levels of Runt-related transcription factor x, Leptin Receptor, Osteocalcin, and Periostin biomarkers. Bone regeneration in both β-TCP/PLLA/PGA and β-TCP was comparable at initial timepoints. Osteogenic cell accumulation was greater in β-TCP/PLLA/PGA than in β-TCP at initial as well as late phases. Periostin expression was more marked in β-TCP/PLLA/PGA. This study demonstrated comparable results between β-TCP/PLLA/PGA and β-TCP in terms of bone regeneration and bioactivity, even with a small material volume of β-TCP/PLLA/PGA and a decreased percentage of β-TCP. Electrospun β-TCP/PLLA/PGA is an ideal nanobiomaterial for inducing bone regeneration through osteoconductivity and bioresorbability in bony defects of the maxillofacial region.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%