To summarize the characteristics of wheelchair-user combination, this paper studied wheelchairs, wheelchair users, nursing staffs and interaction relationship between them. Firstly, the findings of some research on wheelchairs and wheelchair users were investigated, and the studies in four aspects of wheelchairs and their accessories, wheelchair users, wheelchairs and wheelchair users (man-machine system), and skills training for the performance of wheelchair were reviewed. Then "wheelchair-user combination" was put forward based on the relationship between wheelchairs and wheelchair users in real life, and the "wheelchair-user combination" was divided into "WUs-Ws system" and "WUs-Ws-NSs system" according to whether the nursing staffs were needed. Finally, this paper analytically studied the characteristics of wheelchair users, characteristics in use of wheelchair and characteristics of nursing staffs, as well as put forward the characteristics of the wheelchair-user combination.