Three-dimensional electronic scaffolds for monitoring and regulation of multifunctional hybrid tissues

Wang, Xueju; Feiner, Ron; Luan, Haiwen; Zhang, Qihui; Zhao, Shiwei; Zhang, Yi; Han, Mengdi; Li, Yang; Sun, Rujie; Wang, Heling; Liu, Tzu Li; Guo, Xiaogang; Oved, Hadas; Noor, Nadav; Shapira, Assaf; Zhang, Yihui; Huang, Yonggang; Dvir, Tal; Li, Jinghua

doi:10.1016/j.eml.2020.100634

Cited by 42 publications

(30 citation statements)

References 58 publications

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“…cell cultures formed on 3D scaffolds (14,15) and in electrical stimulation and drug release (15). These technologies offer promising avenues for biological research, but they are not, however, designed for interfaces to grown 3D tissues, nor do they provide mechanical support or sensing of forces or displacements of relevance to smooth, skeletal, or cardiac muscle constructs.…”

mentioning

confidence: 99%

Compliant 3D frameworks instrumented with strain sensors for characterization of millimeter-scale engineered muscle tissues

Zhao

Kim

Wang³

et al. 2021

Proc. Natl. Acad. Sci. U.S.A.

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Tissue-on-chip systems represent promising platforms for monitoring and controlling tissue functions in vitro for various purposes in biomedical research. The two-dimensional (2D) layouts of these constructs constrain the types of interactions that can be studied and limit their relevance to three-dimensional (3D) tissues. The development of 3D electronic scaffolds and microphysiological devices with geometries and functions tailored to realistic 3D tissues has the potential to create important possibilities in advanced sensing and control. This study presents classes of compliant 3D frameworks that incorporate microscale strain sensors for high-sensitivity measurements of contractile forces of engineered optogenetic muscle tissue rings, supported by quantitative simulations. Compared with traditional approaches based on optical microscopy, these 3D mechanical frameworks and sensing systems can measure not only motions but also contractile forces with high accuracy and high temporal resolution. Results of active tension force measurements of engineered muscle rings under different stimulation conditions in long-term monitoring settings for over 5 wk and in response to various chemical and drug doses demonstrate the utility of such platforms in sensing and modulation of muscle and other tissues. Possibilities for applications range from drug screening and disease modeling to biohybrid robotic engineering.

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mentioning

confidence: 99%

Compliant 3D frameworks instrumented with strain sensors for characterization of millimeter-scale engineered muscle tissues

Zhao

Kim

Wang³

et al. 2021

Proc. Natl. Acad. Sci. U.S.A.

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“…There now exists a growing body of literature that demonstrates the impactful foundations that 4D electronic scaffolds-specifically, as hierarchical devices with well-controlled microelectrode distributions and diverse, precisely defined 3D geometries-can contribute to enhance the control and regulation of tissue formation and function across a variety of biological tissue. [82,126] Adv. Mater.…”

Section: D µ-Cellular Framework Fabricated Through Directed Assembly ...mentioning

confidence: 99%

“…The use of this technique in creating functional 3D structures has expanded in recent years. [ 76–78 ] Successful demonstrations of directed 3D assembly have been applied to many applications, including electronics/optoelectronics with unconventional form factors, [ 25,79 ] microelectromechanical systems, [ 80 ] energy harvesters, [ 81 ] cell scaffolds, [ 76,82,83 ] multifunctional interfaces to organoids, [ 84 ] electronic microfliers, [ 85 ] microfluidic networks, [ 78 ] and many others.…”

Section: Directed 4d Assembly By Compressive Bucklingmentioning

confidence: 99%

Biomimetic and Biologically Compliant Soft Architectures via 3D and 4D Assembly Methods: A Perspective

et al. 2022

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synthetically. Studying structures found in nature has motivated and will continue to motivate the advancement of 3D fabrication strategies. Progress in this field has seen tremendous growth in recent years and structures that are made with relative ease today, a few decades ago would have seemed impossible. New developments, particularly in the construction of architectures made from soft materials or hybrid structures containing both soft and hard components are continuously emerging. Creation of soft synthetic structures that mimic the properties and functions of biological materials or can interact with, probe, and control living materials continue to drive research in this field.Here, recent contributions from the literature and our research are highlighted and the reports are used to highlight opportunities and current needs for advances in the chemistry of soft materials in the context of their functional integration into 3D architectures of complex form. The methods considered herein serve to highlight a recent paradigm for heterogeneous integration-methods of 4D fabrication exploiting directed assembly and printing to construct complex functional composite material structures.Recent progress in soft material chemistry and enabling methods of 3D and 4D fabrication-emerging programmable material designs and associated assembly methods for the construction of complex functional structures-is highlighted. The underlying advances in this science allow the creation of soft material architectures with properties and shapes that programmably vary with time. The ability to control composition from the molecular to the macroscale is highlighted-most notably through examples that focus on biomimetic and biologically compliant soft materials. Such advances, when coupled with the ability to program material structure and properties across multiple scales via microfabrication, 3D printing, or other assembly techniques, give rise to responsive (4D) architectures. The challenges and prospects for progress in this emerging field in terms of its capacities for integrating chemistry, form, and function are described in the context of exemplary soft material systems demonstrating important but heretofore difficult-to-realize biomimetic and biologically compliant behaviors.

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“…Electronics fabricated with such architecture could be used to guide the formation of cardiac or nervous tissues. [ 142,143 ] An advantage of this 3D platform is that it allows structural reconfiguration via applied strains. Tissues could be cultured in one configuration and transform into another via active structural modulation.…”

Section: D Soft Electronics For Advanced Cell and Tissue Culturementioning

confidence: 99%

3D Interfacing between Soft Electronic Tools and Complex Biological Tissues

Liu

Sun

et al. 2020

Advanced Materials

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Recent developments in soft functional materials have created opportunities for building bioelectronic devices with tissue‐like mechanical properties. Their integration with the human body could enable advanced sensing and stimulation for medical diagnosis and therapies. However, most of the available soft electronics are constructed as planar sheets, which are difficult to interface with the target organs and tissues that have complex 3D structures. Here, the recent approaches are highlighted to building 3D interfaces between soft electronic tools and complex biological organs and tissues. Examples involve mesh devices for conformal contact, imaging‐guided fabrication of organ‐specific electronics, miniaturized probes for neurointerfaces, instrumented scaffold for tissue engineering, and many other soft 3D systems. They represent diverse routes for reconciling the interfacial mismatches between electronic tools and biological tissues. The remaining challenges include device scaling to approach the complexity of target organs, biological data acquisition and processing, 3D manufacturing techniques, etc., providing a range of opportunities for scientific research and technological innovation.

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Three-dimensional electronic scaffolds for monitoring and regulation of multifunctional hybrid tissues

Cited by 42 publications

References 58 publications

Compliant 3D frameworks instrumented with strain sensors for characterization of millimeter-scale engineered muscle tissues

Compliant 3D frameworks instrumented with strain sensors for characterization of millimeter-scale engineered muscle tissues

Biomimetic and Biologically Compliant Soft Architectures via 3D and 4D Assembly Methods: A Perspective

3D Interfacing between Soft Electronic Tools and Complex Biological Tissues

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