Three-dimensional electrospun ECM-based hybrid scaffolds for cardiovascular tissue engineering

Heydarkhan‐Hagvall, Sepideh; Schenke‐Layland, Katja; Dhanasopon, Andrew P.; Rofail, Fady; Smith, Hunter; Wu, Benjamin M.; Shemin, Richard J.; Beygui, Ramin E.; MacLellan, W. Robb

doi:10.1016/j.biomaterials.2008.03.034

Cited by 415 publications

(310 citation statements)

References 52 publications

(64 reference statements)

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“…However, gelatin fibers exhibit higher tensile moduli than collagen fibers. Gelatin also exhibits excellent biodegradability, non-antigenicity, and cost efficiency; similar characteristics to electrospun collagen [44][45][46]. One of the major drawbacks of gelatin is that it dissolves as a colloidal sol at temperatures at or above 37 °C, and gels near room temperature.…”

Section: Gelatinmentioning

confidence: 98%

The Use of Natural Polymers in Tissue Engineering: A Focus on Electrospun Extracellular Matrix Analogues

et al. 2010

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Natural polymers such as collagens, elastin, and fibrinogen make up much of the body's native extracellular matrix (ECM). This ECM provides structure and mechanical integrity to tissues, as well as communicating with the cellular components it supports to help facilitate and regulate daily cellular processes and wound healing. An ideal tissue engineering scaffold would not only replicate the structure of this ECM, but would also replicate the many functions that the ECM performs. In the past decade, the process of electrospinning has proven effective in creating non-woven ECM analogue scaffolds of micro to nanoscale diameter fibers from an array of synthetic and natural polymers. The ability of this fabrication technique to utilize the aforementioned natural polymers to create tissue engineering scaffolds has yielded promising results, both in vitro and in vivo, due in part to the enhanced bioactivity afforded by materials normally found within the human body. This review will present the process of electrospinning and describe the use of natural polymers in the creation of bioactive ECM analogues in tissue engineering.

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Section: Gelatinmentioning

confidence: 98%

The Use of Natural Polymers in Tissue Engineering: A Focus on Electrospun Extracellular Matrix Analogues

et al. 2010

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“…The combination of PCL with different natural polymers such as collagen, elastin and gelatin has revealed that electrospun PCL/gelatin scaffolds showed a higher tensile strength when compared to the other hybrid scaffolds according to Heydarkhan-Hagvall et al [79]. The effects of pore size on cell attachment and migration was determined by in vitro studies using adipose-derived stem cells culture, where cell migration into the scaffold was predominantly seen in the PCL/gelatin hybrid.…”

Section: Poly(ε-caprolactone)-based Scaffoldsmentioning

confidence: 99%

Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering

et al. 2017

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Please cite this article as: Kitsara, M., Agbulut, O., Kontziampasis, D., Chen, Y., Menasché, P., Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering, Acta Biomaterialia (2016), doi: http://dx.doi.org/ 10. 1016/j.actbio.2016.11.014 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractCardiac cell therapy holds a real promise for improving heart function and especially of the chronically failing myocardium. Embedding cells into 3D biodegradable scaffolds may better preserve cell survival and enhance cell engraftment after transplantation, consequently improving cardiac cell therapy compared with direct intramyocardial injection of isolated cells.The primary objective of a scaffold used in tissue engineering is the recreation of the natural 3D environment most suitable for an adequate tissue growth. An important aspect of this commitment is to mimic the fibrillar structure of the extracellular matrix, which provides essential guidance for cell organization, survival, and function. Recent advances in nanotechnology have significantly improved our capacities to mimic the extracellular matrix. Among them, electrospinning is well known for being easy to process and cost effective. Consequently, it is becoming increasingly popular for biomedical applications and it is most definitely the cutting edge technique to make scaffolds that mimic the extracellular matrix for industrial applications.Here, the desirable physico-chemical properties of the electrospun scaffolds for cardiac therapy are described, and polymers are categorized to natural and synthetic. Moreover, the methods used for improving functionalities by providing cells with the necessary chemical cues and a more in vivo-like environment are reported.

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“…Moreover, it has low tensile strength (~23 MPa), but very high elongation at breakage (4700 %) making it a good elastic biomaterial [81] [182]. PCL is used in the production of implants composed of adhered nano/microspheres [183], electrospun fibers [184,185], or porous networks [186] used for regeneration of bone [187,188], ligament [189,190], cartilage [191], nerve [192], and vascular tissues [193]. In addition, PCL is often blended or copolymerized with other polymers like polyesters and polyethers to expedite overall polymer erosion [194].…”

Section: Polyestersmentioning

confidence: 99%

Biodegradable polymers for dental tissue engineering and regeneration

Conte¹,

Riccitiello²,

Luise³

et al. 2017

Biodegradable Polymers: Recent Developments and New Perspectives

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Three-dimensional electrospun ECM-based hybrid scaffolds for cardiovascular tissue engineering

Cited by 415 publications

References 52 publications

The Use of Natural Polymers in Tissue Engineering: A Focus on Electrospun Extracellular Matrix Analogues

The Use of Natural Polymers in Tissue Engineering: A Focus on Electrospun Extracellular Matrix Analogues

Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering

Biodegradable polymers for dental tissue engineering and regeneration

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