Three-dimensional evaluation of perirenal fat volume in patients with nephrolithiasis

Lama, Daniel; Safiullah, Shoaib; Yang, Albert D.; Okhunov, Zhamshid; Landman, Jaime; Clayman, Ralph V.

doi:10.1007/s00240-018-1047-9

Cited by 9 publications

(7 citation statements)

References 29 publications

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“…Recently, a study by Lama et al. [ 10 ], in 40 patients with unilateral nephrolithiasis undergoing percutaneous nephrolithotomy as the primary treatment, showed that the mean PFV of stone-bearing kidneys was significantly greater than non-stone-bearing kidneys.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a study of Lama et al. with a small patient cohort ( n = 40) showed that stone-bearing kidney has a greater perirenal fat volume (PFV) than non-stone-bearing kidney [ 10 ]. However, the calculation of PFV on computerized tomography (CT) scans requires the use of specific imaging software, which may be unavailable in many institutions.…”

Section: Introductionmentioning

confidence: 99%

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High perirenal fat thickness predicts a greater risk of recurrence in Chinese patients with unilateral nephrolithiasis

et al. 2023

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Introduction The aim of this study was to evaluate the association between recurrence-free survival (RFS) and perirenal fat thickness (PFT) in a cohort of Chinese population with unilateral nephrolithiasis. Methods We retrospectively reviewed the medical records of 81 patients with unilateral nephrolithiasis in our center from January 2019 to June 2019. PFT measured on computed tomography (CT) scans was evaluated. Kaplan-Meier curves and log-rank tests were used to assess significant differences in RSF between high-PFT and low-PFT groups within sexes. Univariable and multivariable Cox regression analyses were used to evaluate the potential risk factors for renal stone recurrence. Results High PFT was significantly associated with high BMI and hyperlipidemia ( p = .003 and.047, respectively). The PFT of stone-bearing kidney was significantly greater than PFT of non-stone-bearing kidney (0.77 ± 0.60 cm vs. 0.67 ± 0.58 cm, p = .002) . During the follow-up periods (median 31 months), 21 (25.9%) patients experienced ipsilateral renal stone recurrence. In addition, Kaplan–Meier survival curves showed that patients with low PFT had a significant better RFS than those with high PFT ( p = .012). In the univariable Cox analyses, male sex and high PFT were significantly associated with a poor RFS ( p = .042 and .018, respectively). Moreover, both male sex and high PFT retained significance in the multivariable analyses ( p = .045 and .020, respectively). Conclusions Our findings suggested that PFT is a noninvasive and feasible parameter, which may help in the risk stratification of renal stone recurrence in the follow-up periods.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High perirenal fat thickness predicts a greater risk of recurrence in Chinese patients with unilateral nephrolithiasis

et al. 2023

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“…Current data have shown that PRAT size potentiates the lesions produced by other renal metabolic factors, such as abnormal insulin serum levels and increased glucose resistance or high triglycerides and uric acid levels, all these features being observed in patients with chronic kidney disease [ 10 , 46 ]. Furthermore, according to the results of a recent study, an increase of PRAT in patients with calcium phosphate apatite or uric acidic nephrolithiasis has been noticed [ 47 ]. Since it could not be specified whether there is a direct relationship between the occurrence of these lesions and PRAT volume, further research is needed to clarify this finding [ 47 ].…”

Section: Prat In Chronic Renal Pathologymentioning

confidence: 99%

“…Furthermore, according to the results of a recent study, an increase of PRAT in patients with calcium phosphate apatite or uric acidic nephrolithiasis has been noticed [ 47 ]. Since it could not be specified whether there is a direct relationship between the occurrence of these lesions and PRAT volume, further research is needed to clarify this finding [ 47 ].…”

Section: Prat In Chronic Renal Pathologymentioning

confidence: 99%

Perirenal Adipose Tissue—Current Knowledge and Future Opportunities

Grigoraș

Bălan

Căruntu

et al. 2021

JCM

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The perirenal adipose tissue (PRAT), a component of visceral adipose tissue, has been recently recognized as an important factor that contributes to the maintenance of the cardiovascular system and kidney homeostasis. PRAT is a complex microenvironment consisting of a mixture of white adipocytes and dormant and active brown adipocytes, associated with predipocytes, sympathetic nerve endings, vascular structures, and different types of inflammatory cells. In this review, we summarize the current knowledge about PRAT and discuss its role as a major contributing factor in the pathogenesis of hypertension, obesity, chronic renal diseases, and involvement in tumor progression. The new perspectives of PRAT as an endocrine organ and recent knowledge regarding the possible activation of dormant brown adipocytes are nowadays considered as new areas of research in obesity, in close correlation with renal and cardiovascular pathology. Supplementary PRAT complex intervention in tumor progression may reveal new pathways involved in carcinogenesis and, implicitly, may identify additional targets for tailored cancer therapy.

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“…PRAT thickness could aggravate renal anomalies due to metabolic dysfunction such as abnormal insulin serum levels, high glucose or triglycerides and uric acid, all of which are reported in patients with CKD ( 129 ). Additionally, excess PRAT is detected in patients with calcium phosphate apatite or uric acid nephrolithiasis ( 177 ). However, future research into analyzing the detailed mechanism is warranted.…”

Section: Perirenal Adipose Tissue and Renal Diseasesmentioning

confidence: 99%

Perirenal Adipose Tissue Inflammation: Novel Insights Linking Metabolic Dysfunction to Renal Diseases

et al. 2021

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A healthy adipose tissue (AT) is indispensable to human wellbeing. Among other roles, it contributes to energy homeostasis and provides insulation for internal organs. Adipocytes were previously thought to be a passive store of excess calories, however this view evolved to include an endocrine role. Adipose tissue was shown to synthesize and secrete adipokines that are pertinent to glucose and lipid homeostasis, as well as inflammation. Importantly, the obesity-induced adipose tissue expansion stimulates a plethora of signals capable of triggering an inflammatory response. These inflammatory manifestations of obese AT have been linked to insulin resistance, metabolic syndrome, and type 2 diabetes, and proposed to evoke obesity-induced comorbidities including cardiovascular diseases (CVDs). A growing body of evidence suggests that metabolic disorders, characterized by AT inflammation and accumulation around organs may eventually induce organ dysfunction through a direct local mechanism. Interestingly, perirenal adipose tissue (PRAT), surrounding the kidney, influences renal function and metabolism. In this regard, PRAT emerged as an independent risk factor for chronic kidney disease (CKD) and is even correlated with CVD. Here, we review the available evidence on the impact of PRAT alteration in different metabolic states on the renal and cardiovascular function. We present a broad overview of novel insights linking cardiovascular derangements and CKD with a focus on metabolic disorders affecting PRAT. We also argue that the confluence among these pathways may open several perspectives for future pharmacological therapies against CKD and CVD possibly by modulating PRAT immunometabolism.

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Three-dimensional evaluation of perirenal fat volume in patients with nephrolithiasis

Cited by 9 publications

References 29 publications

High perirenal fat thickness predicts a greater risk of recurrence in Chinese patients with unilateral nephrolithiasis

High perirenal fat thickness predicts a greater risk of recurrence in Chinese patients with unilateral nephrolithiasis

Perirenal Adipose Tissue—Current Knowledge and Future Opportunities

Perirenal Adipose Tissue Inflammation: Novel Insights Linking Metabolic Dysfunction to Renal Diseases

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