Objective: To compare the effect of canting correction in anterior maxillary transverse occlusal planes (AMTOP) and posterior maxillary transverse occlusal planes (PMTOP) on the change of lip canting (LC) in two-jaw surgery (TJS) cases. Materials and Methods: The samples consisted of eight young adult patients (three males and five females, mean age 5 24.1 6 4.5 years) who had skeletal Class III malocclusion (CIII), facial asymmetry (FA), and LC and who underwent TJS. Two-dimensional lateral and posteroanterior cephalograms and three-dimensional facial scanning taken 1 week before (T1) and 6 months after TJS (T2) were combined using the Morpheus 3D program. Six linear and angular variables were measured and statistically analyzed. Results: When comparing the values of the linear and angular variables at the T1 and T2 stages there was significant canting correction of AMTOP (1.7 mm vs 20.3 mm; 3.0u vs 0.1u), PMTOP (3.5 mm vs 0.1 mm, 3.3u vs 20.1u), and LC (3.0 mm vs 0.7 mm, 4.7u vs 2.1u) (all P , .05). Although the angular change ratios (DLC/DAMTOP and DLC/DPMTOP) did not exhibit a significant difference (0.99 vs 0.83), the linear change ratio of DLC/DAMTOP was significantly higher than that of DLC/DPMTOP (1.67 vs 0.74, P , .05). The angular change of DLC showed a significant correlation with DAMTOP (r 2 5 0.64; P , .05). However, the linear change of DLC was significantly correlated with both the angular and linear changes of DAMTOP (r 2 5 0.62 and 0.66; both P , .05). Therefore, the amount of LC change was more related to the canting correction of AMTOP than to that of PMTOP. Conclusion: In TJS cases with CIII, FA, and LC, the amount of canting correction of the AMTOP should be considered to predict the actual LC change. (Angle Orthod. 2012;82:1092-1097