Three‐Dimensional Human Tissue Chips Fabricated by Rapid and Automatic Inkjet Cell Printing

Matsusaki, Michiya; Sakaue, Kayo; Kadowaki, Koji; Akashi, Mitsuru

doi:10.1002/adhm.201200299

Cited by 171 publications

(132 citation statements)

References 27 publications

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“…Bhise et al [93] constructed a liver-ona-chip platform of 3D printed hepatic spheroids for drug toxicity assessment, which could maintain its function after 30 days of culture. Matsusaki et al [94] constructed hierarchical liver tissue micro-arrays using HepG2/HUVECsladen fibronectin and gelatin. The fabricated 3D-human liver chips showed high cell activities and high cell-cell interactions, because the hierarchical sandwich structures were analogous to the native liver structure [94].…”

Section: Bioprinting Of Livermentioning

confidence: 99%

“…Matsusaki et al [94] constructed hierarchical liver tissue micro-arrays using HepG2/HUVECsladen fibronectin and gelatin. The fabricated 3D-human liver chips showed high cell activities and high cell-cell interactions, because the hierarchical sandwich structures were analogous to the native liver structure [94]. In the work by Ma et al [95] it was found that the functions of liver tissue were closely related to the 3D assembly of hepatocytes with the supporting cell types.…”

Section: Bioprinting Of Livermentioning

confidence: 99%

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3D bioprinting for cell culture and tissue fabrication

Jian

Wang

et al. 2018

Bio-des. Manuf.

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Three-dimensional (3D) bioprinting is a computer-assisted technology which precisely controls spatial position of biomaterials, growth factors and living cells, offering unprecedented possibility to bridge the gap between structurally mimic tissue constructs and functional tissues or organoids. We briefly focus on diverse bioinks used in the recent progresses of biofabrication and 3D bioprinting of various tissue architectures including blood vessel, bone, cartilage, skin, heart, liver and nerve systems. This paper provides readers a guideline with the conjunction between bioinks and the targeted tissue or organ types in structuration and final functionalization of these tissue analogues. The challenges and perspectives in 3D bioprinting field are also illustrated.

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Section: Bioprinting Of Livermentioning

confidence: 99%

Section: Bioprinting Of Livermentioning

confidence: 99%

3D bioprinting for cell culture and tissue fabrication

Jian

Wang

et al. 2018

Bio-des. Manuf.

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“…It is promising to produce reliable in vitro models from 2D to 3D. Based on the rapid and automatic inkjet technology, different cells could be deposit in predefined patterns [9,23] (Figure 1b). To construct 3D co-culture, cells can be mixed with collagen by a dual ejection [24].…”

Section: Cell and Environment Controlmentioning

confidence: 99%

“…For example, fluid shear stress was indicated to mediate endothelial cell transcription, proliferation, barrier function, and changes in [8]. (b) 3D micro-tissue arrays by printing of single cells and proteins [9]. (c) Controlled assembly of heterotypic cells in a core-shell scaffold [10].…”

Section: Control Of Physical Factorsmentioning

confidence: 99%

Development and Applications of Microfluidic Devices for Cell Culture in Cell Biology

Yi¹,

Lin²

2016

Mol Biol

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Development of microfluidic culture technology combined with tissue engineering catalyzes the progress in study of cell biology. These tools will promote the understanding of physiological and pathological changes. Cancer cells and stem cells are sensitive to their surroundings, thus could be better explored by controllable microfluidic devices. In this review, we describe the ways to control cell microenvironment and explain how the influencing factors influence cellular behaviors, then present microfluidic-chip-based exemplary applications for cancer models and stem cell differentiation.

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“…For example, depositing living cells at a specific location is useful to help understand how cell behavior such as proliferation, differentiation, and migration is related to local environment (e.g., extracellular matrix and neighboring cells) [1][2][3][4]. Also, in tissue engineering, which seeks to repair injured or ill organs, it is necessary to seed living cells at a precise position in three-dimensional (3D) scaffolds to achieve successful production of artificial tissues or organs [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Feasibility study of a biocompatible pneumatic dispensing system using mouse 3T3-J2 fibroblasts

Lee

Kim

2017

Micro and Nano Syst Lett

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This paper presents results for dispensing living cells using a pneumatic dispensing system to verify the feasibility of using this system to fabricate biomaterials. Living cells (i.e., mouse 3T3-J2 fibroblast) were dispensed with different dispensing pressures in order to evaluate the effect of dispensing process on cell viability and proliferation. Based on the results of a live-dead assay, more than 80% of cell viability has been confirmed which was reasonably similar to that in the control group. Furthermore, measurement of cell metabolic activity after dispensing confirmed that the dispensed cell proliferated at a rate comparable to that of the control group. These results demonstrate that the pneumatic dispensing system is a promising tool for fabrication of biomaterials.

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Three‐Dimensional Human Tissue Chips Fabricated by Rapid and Automatic Inkjet Cell Printing

Cited by 171 publications

References 27 publications

3D bioprinting for cell culture and tissue fabrication

3D bioprinting for cell culture and tissue fabrication

Development and Applications of Microfluidic Devices for Cell Culture in Cell Biology

Feasibility study of a biocompatible pneumatic dispensing system using mouse 3T3-J2 fibroblasts

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