Three-Dimensional Images and Vessel Rendering Using Optical Coherence Tomography

Thomas, Meghan W.; Grichnik, James M.; Izatt, Joseph A.

doi:10.1001/archderm.143.11.1468

Cited by 10 publications

(3 citation statements)

References 7 publications

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“…These details may have some applicability in laser treatment of haemangiomas, and future studies to explore OCT imaging of haemangiomas are necessary. Previous studies demonstrated a 3D OCT image of a similar lesion [57] and in another study OCT images matched histology of haemangiomas [58]. The use of Doppler OCT may have a potential for identifying feeding vessels and prognosis estimation in capillary haemangiomas and vessels in general during laser treatment, which has been demonstrated using Doppler US [59], and in a study of one port-wine stain by Doppler OCT [60].…”

Section: Haemangiomasmentioning

confidence: 76%

OCT imaging of skin cancer and other dermatological diseases

Mogensen

Thrane

Jørgensen

et al. 2009

Journal of Biophotonics

175

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Optical coherence tomography (OCT) provides clinicians and researchers with micrometer-resolution, in vivo, cross-sectional images of human skin up to several millimeter depth. This review of OCT imaging applied within dermatology covers the application of OCT to normal skin, and reports on a large number of applications in the fields of non-melanoma skin cancer, malignant melanomas, psoriasis and dermatitis, infestations, bullous skin diseases, tattoos, nails, haemangiomas, and other skin diseases.

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Section: Haemangiomasmentioning

confidence: 76%

OCT imaging of skin cancer and other dermatological diseases

Mogensen

Thrane

Jørgensen

et al. 2009

Journal of Biophotonics

175

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“…IVM is commonly used to determine the size and architecture of tumors and their vasculature. RBCs can be used as an endogenous contrast agent to visualize blood vessels under conventional trans‐illumination, linearly polarized light [52], OCT [139] or OFDI [148] (Figure 1B). High‐molecular‐weight fluorescent tracers (e.g., FITC‐conjugated 2000 kDa dextran) are injected to temporarily demarcate the blood vessels for fluorescence microscopy until the extravasation of the tracers degrades contrast.…”

Section: Intravital Microscopy Studies Of Tumor Microvasculaturementioning

confidence: 99%

Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre-Clinical Models

et al. 2010

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Intravital imaging techniques have provided unprecedented insight into tumor microcirculation and microenvironment. For example, these techniques allowed quantitative evaluations of tumor blood vasculature to uncover its abnormal organization, structure and function (e.g., hyperpermeability, heterogeneous and compromised blood flow). Similarly, imaging of functional lymphatics has documented their absence inside tumors. These abnormalities result in elevated interstitial fluid pressure and hinder the delivery of therapeutic agents to tumors. In addition, they induce a hostile microenvironment characterized by hypoxia and acidosis, as documented by intravital imaging. The abnormal microenvironment further lowers the effectiveness of anti-tumor treatments such as radiation therapy and chemotherapy. In addition to these mechanistic insights, intravital imaging may also offer new opportunities to improve therapy. For example, tumor angiogenesis results in immature, dysfunctional vessels-primarily caused by an imbalance in production of pro-and anti-angiogenic factors by the tumors. Restoring the balance of pro-and anti-angiogenic signaling in tumors can "normalize" tumor vasculature and thus, improve its function, as demonstrated by intravital imaging studies in preclinical models and in cancer patients. Administration of cytotoxic therapy during periods of vascular normalization has the potential to enhance treatment efficacy.

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“…The most common application of IVM is to determine the size and architecture of tumors and their vasculature, parameters often of interest with regard to dormant tumors and metastases. To visualize blood vessels, RBCs can be used as an endogenous contrast agent under conventional transillumination, linearly polarized light (5), or optical coherence tomography (6). For fluorescence microscopy, high‐molecular‐weight fluorescent tracers (e.g.…”

Section: Imaging Tumor Vesselsmentioning

confidence: 99%

Imaging angiogenesis and the microenvironment

Jain¹

2008

APMIS

143

110

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Intravital microscopy has provided unprecedented insights into tumor pathophysiology, including angiogenesis and the microenvironment. Tumor vasculature shows an abnormal organization, structure, and function. Tumor vessels are leaky, blood flow is heterogeneous and often compromised. Vascular hyperpermeability and the lack of functional lymphatic vessels inside tumors causes elevation of interstitial fluid pressure in solid tumors. These abnormalities form physiological barriers to the delivery of therapeutic agents to tumors and also lead to a hostile microenvironment characterized by hypoxia and acidosis, which hinders the effectiveness of anti-tumor treatments such as radiation therapy and chemotherapy. In addition, host-tumor interactions regulate expression of pro-and antiangiogenic factors, resulting in pathophysiological characteristics of the tumor. On the other hand, in a physiological setting, angiogenic vessels become mature and form long-lasting functional units. Restoring the balance of pro-and anti-angiogenic factors in tumors may ''normalize'' tumor vasculature and thus improve its function. Administration of cytotoxic therapy during the vascular normalization would enhance its efficacy.

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Three-Dimensional Images and Vessel Rendering Using Optical Coherence Tomography

Cited by 10 publications

References 7 publications

OCT imaging of skin cancer and other dermatological diseases

OCT imaging of skin cancer and other dermatological diseases

Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre-Clinical Models

Imaging angiogenesis and the microenvironment

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