Three-dimensional magnetic nanoparticle imaging using small field gradient and multiple pickup coils

Sasayama, Teruyoshi; Tsujita, Yuya; Morishita, Manabu; Morimoto, Masahiro; Yonetani, Takashi; Enpuku, Keiji

doi:10.1016/j.jmmm.2016.10.107

Cited by 19 publications

(11 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a previous work, we developed a three-dimensional MPI system using the FFL and two pickup coils. 15) We showed that the combination of the FFL and the two pickup coils allowed us to obtain three-dimensional MNP distribution information. This demonstrated that two-dimensional scanning of the sample is sufficient in this case.…”

Section: Introductionmentioning

confidence: 89%

See 1 more Smart Citation

Three-dimensional imaging of magnetic nanoparticles using multiple pickup coils and field-free line

Morimoto

Hamanaga

Tanaka

et al. 2018

Jpn. J. Appl. Phys.

Self Cite

View full text Add to dashboard Cite

We performed three-dimensional detection of magnetic nanoparticle (MNP) samples using third-harmonic signal detection. In this method, a combination of five pickup coils and a gradient field with a field-free line was used to acquire three-dimensional MNP sample position information. The resulting two-dimensional maps of the signal fields generated by the MNP samples are sufficient for three-dimensional MNP image reconstruction. In the experiments, two MNP samples with different Fe contents were set at different positions. Two-dimensional field maps were measured using the five pickup coils, and the three-dimensional MNP sample distribution was then reconstructed from these field maps by solving an inversion problem. We demonstrated three-dimensional detection of two MNP samples where we reconstructed the three-dimensional positions and the Fe contents of these two MNP samples with reasonable accuracy. These results indicate the feasibility of the proposed system for threedimensional magnetic particle imaging.

show abstract

Section: Introductionmentioning

confidence: 89%

“…An FFL was thus generated along this line. 15) It was shown that the gradient field mainly has x and y components near the FFL, and the field distribution can be expressed approximately as…”

Section: Methodsmentioning

confidence: 99%

Three-dimensional imaging of magnetic nanoparticles using multiple pickup coils and field-free line

Morimoto

Hamanaga

Tanaka

et al. 2018

Jpn. J. Appl. Phys.

Self Cite

View full text Add to dashboard Cite

show abstract

“…For this purpose, we have been developing an MPI system using a weak field gradient and multiple pickup coils. 11,12) It was shown by us 13) and Ref. 14 that the field gradient can be decreased without degrading the spatial resolution when we use an AC excitation field with a small amplitude.…”

Section: Introductionmentioning

confidence: 96%

Three-dimensional detection of magnetic nanoparticles using a field-free line with weak field gradient and multiple pickup coils

Hamanaga

Yonetani

Sasayama

et al. 2019

Jpn. J. Appl. Phys.

Self Cite

View full text Add to dashboard Cite

We performed three-dimensional detection of magnetic nanoparticle (MNP) samples using the combination of a field-free line (FFL) and multiple pickup coils. In this method, two-dimensional maps of the signal fields generated by the MNP samples were used to reconstruct a threedimensional image of the MNP concentration. In the experiment, a weak field gradient of the FFL (0.06-0.13 T m −1 ) was used. The degradation of the imaging quality owing to the weak field gradient was compensated using ten field maps. We successfully demonstrated the three-dimensional detection of two MNP samples. The Fe content of each sample was 10 and 20 μg and the spacing for both samples was 16 mm. The results confirm the effectiveness of the present method for MNP detection using a weak field gradient. We also quantitatively discuss how the imaging quality degrades when the field gradient is decreased.

show abstract

“…Among the magnetic materials for biomedical applications, superparamagnetic nanoparticles have been gaining more attention due to their potential as not only therapeutic agents for magnetic hyperthermia but also as diagnostic agents for magnetic particle imaging, which has been proposed to visualize the spatial distribution of superparamagnetic nanoparticles recently . So far, a MRI contrast agent named Resovist® that is clinically approved for human use has been widely used to evaluate magnetic hyperthermia and/or magnetic particle imaging applications . To the best of our knowledge, there is little or no information on its heating property dependence on the applied magnetic field.…”

Section: Introductionmentioning

confidence: 99%

Magnetic field dependence of heating property of resovist® for magnetic hyperthermia

Tonthat

Yamamoto

Aki

et al. 2018

IEEJ Transactions Elec Engng

View full text Add to dashboard Cite

Resovist ® , a MRI contrast agent, has been gaining more attention due to its potential as a therapeutic agent in magnetic hyperthermia and a diagnostic agent in magnetic particle imaging. In this study, we examined the dependence of heating property quantified by the specific absorption rate (SAR) by manipulating the applied magnetic field amplitude and frequency (H = 1.8-7.1 kA/m, f = 500 kHz, and H = 4.8 kA/m, f = 200-1000 kHz). The results indicate that the SAR was linearly proportional to amplitude square and frequency. In addition, the heating efficiency (e.g., SAR = 44 W/g at H = 7.1 kA/m, f = 500 kHz) was sufficient to treat the tumor, which suggests the effectiveness of Resovist ® for hyperthermia. The results obtained here may enable us to find the optimal conditions of applied magnetic field and the amount of Resovist ® required for treatment.

show abstract

Three-dimensional magnetic nanoparticle imaging using small field gradient and multiple pickup coils

Cited by 19 publications

References 16 publications

Three-dimensional imaging of magnetic nanoparticles using multiple pickup coils and field-free line

Three-dimensional imaging of magnetic nanoparticles using multiple pickup coils and field-free line

Three-dimensional detection of magnetic nanoparticles using a field-free line with weak field gradient and multiple pickup coils

Magnetic field dependence of heating property of resovist® for magnetic hyperthermia

Contact Info

Product

Resources

About