Three dimensional micro integrated fluid systems (MIFS) fabricated by stereo lithography

Ikuta, Koji; Hirowatari, K.; Ogata, Toshiyuki

doi:10.1109/memsys.1994.555588

Cited by 93 publications

(56 citation statements)

References 3 publications

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“…Circles with a diameter of 200 Am were centered on the analysis cavities and etched through the silicon substrate. The backside fluid channels and fluid interfaces were created using stereolithography (23). The fluid interface design incorporated a network of 800-Am-wide fluid channels where each channel covered two analysis cavities.…”

Section: Methodsmentioning

confidence: 99%

Quantification of the Heterogeneity in Breast Cancer Cell Lines Using Whole-Cell Impedance Spectroscopy

Han

Yang

Frazier

2007

Clinical Cancer Research

194

132

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Purpose: Quantification of the heterogeneity of tumor cell populations is of interest for many diagnostic and therapeutic applications, including determining the cancerous stage of tumors. We attempted to differentiate human breast cancer cell lines from different pathologic stages and compare that with a normal human breast tissue cell line by characterizing the impedance properties of each cell line. Experimental Design: A microelectrical impedance spectroscopy system has been developed that can trap a single cell into an analysis cavity and measure the electrical impedance of the captured cell over a frequency range from 100 Hz to 3.0 MHz. Normal human breast tissue cell line MCF-10A, early-stage breast cancer cell line MCF-7, invasive human breast cancer cell line MDA-MB-231, and metastasized human breast cancer cell line MDA-MB-435 were used.

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Section: Methodsmentioning

confidence: 99%

Quantification of the Heterogeneity in Breast Cancer Cell Lines Using Whole-Cell Impedance Spectroscopy

Han

Yang

Frazier

2007

Clinical Cancer Research

194

132

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“…1). Since Ikuta et al introduced this technology in the early 1990s, many attempts have been made to apply it in various fields, such as lab-on-achip, micro-actuators, and prototype fabrication (15,16). MSTL enables the fabrication of 3D free-form structures at the micron scale, and the inner architecture can also be precisely controlled using CAD/CAM technology such as with SL.…”

Section: Stereolithography (Sl)mentioning

confidence: 99%

Solid Free-form Fabrication Technology and Its Application to Bone Tissue Engineering

2010

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The development of scaffolds for use in cell-based therapies to repair damaged bone tissue has become a critical component in the field of bone tissue engineering. However, design of scaffolds using conventional fabrication techniques has limited further advancement, due to a lack of the required precision and reproducibility. To overcome these constraints, bone tissue engineers have focused on solid free-form fabrication (SFF) techniques to generate porous, fully interconnected scaffolds for bone tissue engineering applications. This paper reviews the potential application of SFF fabrication technologies for bone tissue engineering with respect to scaffold fabrication. In the near future, bone scaffolds made using SFF apparatus should become effective therapies for bone defects.

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“…They used a laser spot focused to a 5-μm diameter and the resin vat is scanned underneath it to cure a layer. Examples of devices built with this method include tubes, manifolds, and springs and flexible microactuators [44] and fluid channels on silicon [45]. Takagi and Nakajima [46] have demonstrated the use of this technology for connecting MEMS gears together on a substrate.…”

Section: Vector Scan Micro-vat Photopolymerizationmentioning

confidence: 99%

Vat Photopolymerization Processes

Gibson

Rosen

Stucker

2015

Additive Manufacturing Technologies

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Photopolymerization processes make use of liquid, radiation-curable resins, or photopolymers, as their primary materials. Most photopolymers react to radiation in the ultraviolet (UV) range of wavelengths, but some visible light systems are used as well. Upon irradiation, these materials undergo a chemical reaction to become solid. This reaction is called photopolymerization, and is typically complex, involving many chemical participants.Photopolymers were developed in the late 1960s and soon became widely applied in several commercial areas, most notably the coating and printing industry. Many of the glossy coatings on paper and cardboard, for example, are photopolymers. Additionally, photo-curable resins are used in dentistry, such as for sealing the top surfaces of teeth to fill in deep grooves and prevent cavities. In these applications, coatings are cured by radiation that blankets the resin without the need for patterning either the material or the radiation. This changed with the introduction of stereolithography, the first vat photopolymerization process.

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Three dimensional micro integrated fluid systems (MIFS) fabricated by stereo lithography

Cited by 93 publications

References 3 publications

Quantification of the Heterogeneity in Breast Cancer Cell Lines Using Whole-Cell Impedance Spectroscopy

Quantification of the Heterogeneity in Breast Cancer Cell Lines Using Whole-Cell Impedance Spectroscopy

Solid Free-form Fabrication Technology and Its Application to Bone Tissue Engineering

Vat Photopolymerization Processes

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