Three‐dimensional power Doppler ultrasound in cervical carcinoma: monitoring treatment response to radiotherapy

Abstract

Objectives To investigate, using three-dimensional power Doppler ultrasound (3D-PDU), alterations in cervical intratumoral vascularization during and after radiotherapy. Methods

The Role of Ultrasound in the Assessment of Uterine Cervical Cancer

“…More recently, Huang et al used 3D power Doppler ultrasound for monitoring the response to radiotherapy and to detect tumor recurrence [39]. They found that this technique is useful to assess tumor response during treatment, since responding tumors showed a significant decrease in vascularization, and also it showed a better sensitivity than serum markers to detect recurrence.…”

Pulsatility Index and Hypoxia Inducible Factor-1α Expression Predict the Clinical Response after External Radiation in Patients with Stage IIB to IVA Cervical Cancer

“…Lower intratumoral PI is associated with higher vascularization and tissue oxygenation distal from the sampling site. Thus, tumor with lower PI should have better response to radiation (Huang et al, 2013). We demonstrate that patients with lower PI demonstrated better response to radiation.…”

“…Intratumoral blood flow correlated to several tumor characteristics, such as grade, histology type, volume, and stage. Tumor with poor differentiation, higher volume, and more advance stage present with higher vascularization characterized by decreased RI and PI (Huang et al, 2013;Mangla and Singla, 2015). RI decreases significantly after radiation which indicate decreased perfusion and oxygenation to cervical tissue after radiation (Alcazar et al, 2003;Mangla and Singla, 2015).…”

Hubungan gambaran spektral pulse wave doppler dengan respon klinis terapi radiasi eksternal pada kanker serviks stadium IIB-IVA

“…Terdapat berbagai faktor yang mempengaruhi respons radiasi terutama adalah faktor oksigenasi kanker, dimana pada jaringan kanker yang kaya oksigen maka respons terapi radiasi akan lebih baik karena mekanisme kerusakan DNA melalui pembentukan radikal bebas lebih besar dibandingkan sel yang mengalami hipoksia (Gambar 1). [12][13][14][15][16][17][18][19][20] Oksigen memainkan peran penting pada respons kanker dengan dosis padat terhadap radioterapi. Kanker yang sangat ter-vaskularisasi memiliki pengiriman oksigen lebih banyak dan karena itu, respon yang lebih baik untuk kemoradiasi daripada tumor dengan vaskularisasi minimal.…”

“…Teknik pencitraan fungsional menggunakan USG Doppler dapat menampilkan perfusi jaringan secara in vivo dengan menampilkan perfusi mikro sirkulasi dari lesi dan menggambarkan status oksigenasi secara langsung. [12][13][14][15][16][17][18][19][20] Hasil penelitian sebelumnya menemukan hasil yang berbeda-beda. Terdapat penelitian yang menemukan bahwa kanker dengan vaskularisasi baik, sebagaimana dinilai oleh Transvaginal Colour Doppler sonography (TVCD), memiliki respon yang lebih baik untuk kemoradioterapi dari tumor yang sangat tervaskularisasi.…”