AbstrakLesi pra kanker serviks adalah awal perubahan menuju kanker serviks. Program pengendalian kanker serviks melalui pemeriksaan Visual Inspection with Acetic Acid (VIA) di tingkat Puskesmas dapat menurunkan insiden kanker serviks hingga 83,6%. Kanker serviks ini berkaitan dengan banyak faktor risiko.Tujuan: Menganalisis hubungan antara faktor risiko dengan kejadian lesi pra kanker serviks. Metode: Cross sectional yang dilakukan di wilayah kerja Puskesmas Muara Bungo 1 dari bulan Februari sampai Mei 2019 terhadap 362 responden. Pengambilan sampel menggunakan metode multistage random sampling. Pengambilan data menggunakan kuisioner dan observasi. Data dianalisis menggunakan uji Chi-square. Hasil: Terdapat hubungan signifikan (p<0,05) antara kejadian lesi prakanker serviks dengan usia >35 tahun, usia pertama kali berhubungan seksual <20tahun, jumlah paritas ≥4kali, menggunakan pembersih vagina dan lama penggunaan kontrasepsi hormonal ≥5 tahun. Jumlah pasangan seksual, paparan asap rokok dan riwayat keluarga kanker serviks, tidak memiliki hubungan yang signifikan dengan kejadian lesi pra kanker serviks (p≥0,05). Faktor risiko yang paling dominan adalah usia pertama kali berhubungan seksual <20 tahun (p=0,008; OR: 6,092). Simpulan: Faktor risiko usia, usia pertama kali berhubungan seksual, jumlah paritas, menggunakan pembersih vagina dan lama menggunakan kontrasepsi hormonal berhubungan dengan kejadian lesi prakanker serviks.Kata kunci: lesi pra kanker serviks, VIA, faktor-faktor risiko AbstractThe program for controlling cervical cancer through Visual Inspection with Acetic Acid (VIA) at the Public Health level can reduce the incidence of cervical cancer by 83.6%. This cervical cancer is associated with many risk factors. Objectives: To analyzed the relationship between risk factors and the incidence of precancerous lesion of cervical. Methods: This was a cross sectional design with multistage random sampling method. This study was conducted at Muara Bungo 1's Health Center from February until May in 2019 on 362 respondents. Sampling uses the MultistageRandom Sampling Method. The data collected by questionnaires and observations. Data were analyzed by Chi-square test. Results: There were significant relationship (p <0.05) between the incidence of pre-cervical cancer lesions with risk factors of age more than 35 years old, age of first sexual intercourse less than 20 years old, the number of parity at least for four times, using vaginal cleansers and duration of use of hormonal contraception at least for five years, exposure to cigarette smoked and a family history of cervical cancer, did not have a significant relationship with the incidence of pre-cancerous lesions of cervical cancer (p>0.05). The most dominant risk factor was the age of first sexual intercourse less than twenty years old. (p = 0.008; OR: 6,092). Conclusion: The risk factor of age, age of first sexual intercourse, the number of parity, using vaginal cleansers and duration of use of hormonal contraception relations with the precancerous lesion of...

Tujuan: Mengetahui hubungan antara gambaran spektral Doppler USG transrektal Pulse Wave Doppler dengan respon klinis terapi radiasi eksternal pada kanker serviks stadium lokal lanjut (IIB-IVA). Metode: Menggunakan metode Prepost Design secara prospektif, dilakukan pemeriksaan Pulse wave Doppler menggunakan probe transrektal pada pasien kanker serviks stadium IIB-IVA. Pada pasien dilakukan pengukuran ukuran tumor secara ultrasonografi dan klinis sebagai ukuran awal tumor untuk menilai respon radiasi. Jumlah sampel adalah 60 untuk kelompok dengan hasil spektral Doppler baik dan buruk, yang dilakukan terapi radiasi eksternal dan dilakukan pengukuran masa kembali secara USG dan klinis untuk menentukan kriteria respon terapi. Hasil: Kelompok respon klinis buruk sebanyak 9 (75,0%) memiliki spektral vaskularisasi buruk dan sebanyak 3 (25,0%) memiliki spektral vaskularusasi baik sedangkan untuk respon klinis baik sebanyak 19(41,3%) memiliki spektral vaskularisasi buruk dan sebanyak 27 (58,7%) memiliki spektral vaskularisasi baik. Pada analisis dengan uji exact Fisher ditemukan hubungan yang bermakna (p<0,05) antara gambaran spectral PW Doppler transrektal dengan respon klinis terapi radiasi eksternal pada kanker serviks stadium IIB-IVA dengan nilai Relative Risk (RR) 3.214 kali. Kesimpulan: Terdapat hubungan yang bermakna antara gambaran spektral Doppler dengan respon klinis terapi radiasi eksternal pada kanker serviks stadium IIB-IVA.

BACKGROUND: Cervical cancer was the fourth common women cancer in the world and the second most in Indonesia. Chemotherapy has been evaluated as a therapy strategy to treat cervical cancer stage IB2 and IIA2 prior the radical hysterectomy. Neoadjuvant chemotherapy was still being a controversy for the chemotherapy resistance patient and will delay the definitive therapy. A marker is needed to identify patient which more relatively resistant to chemotherapy. Squamous cell carcinoma (SCC) type was known to have a better response to neoadjuvant chemotherapy than non-SCC (nSCC) type, but they are no studies at Dr. M. Djamil Padang General Hospital yet on this matter before. OBJECTIVE: The objectives of the study were to obtain the relationship between histopathology type and neoadjuvant chemotherapy response for cervical cancer stage IB2 and IIA2. METHODS: This cohort analytic study conducted at Dr. M Djamil Padang Hospital which obtained 35 samples of stage IB2 and IIA2 cervical cancer patients whom treated with neoadjuvant chemotherapy. Results of histopathology are based on biopsy at diagnosis done for cervical cancer and chemotherapy response is based on transrectal ultrasound examinations before and after given neoadjuvant chemotherapy with response evaluation criteria in solid tumors criteria. RESULTS: Complete response and partial response in the SCC and nSCC group were 32%–50%, while stable disease (SD) and progressive disease were 68% in the SCC group to 50% in the nSCC group. CONCLUSION: There was no significant relationship between histopathological type and neoadjuvant chemotherapy response for cervical cancer stage IB2 and IIA2 (p = 0.44).

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Objective: To report the case of primary fallopian tube carcinoma metastatic to cervix and omentum, but not infiltrate the ovariumMethod: Case Report Case: A 40 years old woman presented with gradual onset pain and swelling of the abdomen. The patient was diagnosed with suspected ovarian carcinoma. After examination, the patient prepared for laparotomy; salpingo-oophorectomy, omentectomy, mass resection from pelvic and rectum  Result: The hystological examination result was high grade serous carcinoma from the fallopian tube metastasis to cavum douglas and omentum. This case is a rare case because the tubal carcinoma was metastasis to cavum douglas and omentum without infiltrate the ovarium.Discussion: Primary carcinoma of the fallopian tube is rare and accounts for about 0.14-1.8% of all gynecological malignancies. Clinically the diagnose of tubal carcinoma very similar to ovarian cancer, the diagnose can not distinguished pre operative. The new staging of FIGO may be reference for diagnostic and treatment of the desease. Thorough staging laparotomy is an important part of early management and systemic treatment. Keywords: tubal carcinoma, PFTC, metastasis, high grade serous carcinoma