AbstrakLesi pra kanker serviks adalah awal perubahan menuju kanker serviks. Program pengendalian kanker serviks melalui pemeriksaan Visual Inspection with Acetic Acid (VIA) di tingkat Puskesmas dapat menurunkan insiden kanker serviks hingga 83,6%. Kanker serviks ini berkaitan dengan banyak faktor risiko.Tujuan: Menganalisis hubungan antara faktor risiko dengan kejadian lesi pra kanker serviks. Metode: Cross sectional yang dilakukan di wilayah kerja Puskesmas Muara Bungo 1 dari bulan Februari sampai Mei 2019 terhadap 362 responden. Pengambilan sampel menggunakan metode multistage random sampling. Pengambilan data menggunakan kuisioner dan observasi. Data dianalisis menggunakan uji Chi-square. Hasil: Terdapat hubungan signifikan (p<0,05) antara kejadian lesi prakanker serviks dengan usia >35 tahun, usia pertama kali berhubungan seksual <20tahun, jumlah paritas ≥4kali, menggunakan pembersih vagina dan lama penggunaan kontrasepsi hormonal ≥5 tahun. Jumlah pasangan seksual, paparan asap rokok dan riwayat keluarga kanker serviks, tidak memiliki hubungan yang signifikan dengan kejadian lesi pra kanker serviks (p≥0,05). Faktor risiko yang paling dominan adalah usia pertama kali berhubungan seksual <20 tahun (p=0,008; OR: 6,092). Simpulan: Faktor risiko usia, usia pertama kali berhubungan seksual, jumlah paritas, menggunakan pembersih vagina dan lama menggunakan kontrasepsi hormonal berhubungan dengan kejadian lesi prakanker serviks.Kata kunci: lesi pra kanker serviks, VIA, faktor-faktor risiko AbstractThe program for controlling cervical cancer through Visual Inspection with Acetic Acid (VIA) at the Public Health level can reduce the incidence of cervical cancer by 83.6%. This cervical cancer is associated with many risk factors. Objectives: To analyzed the relationship between risk factors and the incidence of precancerous lesion of cervical. Methods: This was a cross sectional design with multistage random sampling method. This study was conducted at Muara Bungo 1's Health Center from February until May in 2019 on 362 respondents. Sampling uses the MultistageRandom Sampling Method. The data collected by questionnaires and observations. Data were analyzed by Chi-square test. Results: There were significant relationship (p <0.05) between the incidence of pre-cervical cancer lesions with risk factors of age more than 35 years old, age of first sexual intercourse less than 20 years old, the number of parity at least for four times, using vaginal cleansers and duration of use of hormonal contraception at least for five years, exposure to cigarette smoked and a family history of cervical cancer, did not have a significant relationship with the incidence of pre-cancerous lesions of cervical cancer (p>0.05). The most dominant risk factor was the age of first sexual intercourse less than twenty years old. (p = 0.008; OR: 6,092). Conclusion: The risk factor of age, age of first sexual intercourse, the number of parity, using vaginal cleansers and duration of use of hormonal contraception relations with the precancerous lesion of...