Three high doses of buprenorphine in the treatment of prolonged and severe opium dependence: a new access

Abstract

Background: Heavy and prolonged opium dependence is a progressing problem in the East. For the treatment of opium dependence, buprenorphine can be prescribed less frequently than daily due to its long half-life. Objective: To administered three high doses buprenorphine instead of daily use to reduce probability of buprenorphine dependence. Results: The prescription of three high doses of 32, 96 and 72 mg buprenorphine was tolerated conveniently. Administration of high doses of buprenorphine completely improved opium withdrawal symptoms. Discussion: The current work indicated that few high doses of buprenorphine, could be adequate and satisfactory for the improvement of heavy and prolonged opium dependence. Conclusions:We came to this result that administration of high dose buprenorphine looks to be convenient, acceptable and tolerable. More research studies should be of interest as high buprenorphine doses are getting more general clinically. We concluded that three doses of 32, 72 and 96 mg buprenorphine, could be adequate for the improvement of severe opium use disorder.

“Efficacy of Buprenorphine in the Treatment of Suicide”

“…Besides, buprenorphine is a partial agonist of mu-opioid receptor, so it decreases the level of suicidal desire, depression, dysphoria, anxiety, pain, and opioid withdrawal symptoms. In addition, buprenorphine is a strong kappa receptor antagonist, so it reduces suicidal thoughts, and depression [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29].…”