Three methylated flavones from Thymus vulgaris

The Anti-Helicobacter pylori Flavones in a Brazilian Plant, Hyptis fasciculata, and the Activity of Methoxyflavones

“…The structure of compound 1 was identified as cirsilineol. 6) We demonstrated that the NOESY spectra was observed between 6-OCH 3 and 7-OCH 3 , 7-OCH 3 and 8-H, 3-H and 2Ј-H, and 2Ј-H and 3Ј-OCH 3 . Compound 2, a pale yellow crystal with molecular formula C 17 H 14 O 6 had spectral data resembling compound 1.…”

The Roles of a Flavone-6-Hydroxylase and 7-O-Demethylation in the Flavone Biosynthetic Network of Sweet Basil

“…Because it appears that flavonoid 7-O-methylation is a prerequisite for 6-hydroxylation in these two mint species, the first question is whether this route is common in the Lamiaceae and whether it is shared by non-mints producing identical or very similar flavones, such as Alnus (48), Rubus (49), and Eupatorium (50), all of which are reported to accumulate SALV. In the Lamiaceae, phytochemical data for some groups, such as Thymus (51,52), Origanum (53), and Orthosiphon (54), indicate that they only accumulate 6-substituted flavonoids possessing 7-O-methylated hydroxyl moieties and therefore could well follow the same pattern. Likewise, the discovery of the flavonoid 7-O-demethylation prompts an investigation into the frequency of demethylation in flavonoid metabolism.…”

Effective Cytochrome P450 (CYP) Inhibitor Isolated from Thyme (Thymus saturoides) Purchased from a Japanese Market

“…The active compound (1) isolated from thyme was identified as a yellow amorphous powder with the molecular formula of C 19 (1) has previously been isolated from the Sideritis genus 11) and Thymus species, [12][13][14][15] as well as from such other plant species as the Egyptian medicinal y To whom correspondence should be addressed. Fax: +81-3-5477-2674; E-mail: abe@nodai.ac.jp Abbreviations: TLC, thin layer chromatography; HRESI-MS, high resolution electron spray ionization mass spectrometry plant, Cleome droserifolia, and the Chinese herb, Rabdosia rubescen.…”