Three new dihydroisocoumarin glycosides with antimicrobial activities from Scorzonera aucheriana

Dihydroisocoumarins and Phenylglycosides from Scorzonera longiana, Their Antimicrobial Activities and Molecular Docking Studies

“…Various dihydroisocoumarins and dihydroisocoumarin glycosides (hydrangenol 4‐ O‐β ‐D‐glucoside, scorzo‐tomentosin 4‐ O‐β ‐D‐glucoside, hydrangenol, scorzocreticin, scorzotomentosin, scorzocreticoside I, scorzocreticoside II, hydrangenol 4‐ O‐β ‐D‐apiofuranosyl‐(1‐6)‐ β ‐D‐glucopyranoside, 3 S ‐hydrangenol 4‐ O‐β ‐L‐rhamnopyranosyl‐(1‐3)‐ β ‐D‐glucopyranoside, 8‐ O‐ [‐L‐rhamnopyranosyl(1‐6)‐ β ‐D‐gluco‐pyranosyl] scorzocreticin, hydrangenol 8‐ O‐β ‐D‐glucopyranoside, scorzo‐pygmaecoside, thunberginol C, thunberginol F, and thunberginol G) from Scorzonera species ( S. tomentosa , S. judaica , S. latifolia , S. pygmaea , S. longiana , and S. papposa ) are mentioned in the literature [3,7,13–15,18–20,23,25,27–28,30,32–36,43] …”

“…The compounds isolated from the aerial parts of Scorzonera aucheriana , scorzoaucherioside II and iso‐scorzopygmaecoside possessed strong anti‐tuberculosis activity with MIC of 21.2 μg/mL and 25.6 μg/mL values, respectively. Enterococcus faecalis (Gram (+) strain) was reported to be sensitive to scorzopygmaecoside and scorzocreticoside II with MIC values of 135 μg/mL and 200 μg/mL, respectively [36] …”

“…Ampicillin (10–128 mg/mL), streptomycin 4 mg/mL, and fluconazole (8 mg/mL) were used as standard antibacterial and antifungal drugs, respectively ( Table 3). The 1/10 dilution of solvent was used as a control [36] …”

“…Numerous phytochemical analyses and studies on the biological activity of Scorzonera species have been conducted with regard to the ethnobotanical value of the genus [3,10–12] . Phytochemical studies on Scorzonera species have shown the presence of flavonoids, dihydroisocoumarins, sesquiterpenes, triterpenes, stilbenes, quinic acid, chlorogenic acid, caffeic acid derivatives, and other bioactive compounds [3,7,8,9,11–37] . Biological evaluation of the isolated compounds and extracts/fractions of Scorzonera species was also reported [3,11,12,36–43] …”

“…Enterococcus faecalis (Gram (+) strain) was reported to be sensitive to scorzopygmaecoside and scorzocreticoside II with MIC values of 135 μg/mL and 200 μg/mL, respectively. [36] In this work, MIC values of all isolates (1-7) were investigated against nine microorganisms. [54][55] They generally showed good activities against Ms, gram (+) (E. faecalis and B. cereus), and fungi (C. albicans and S. cerevisiae) within the range of 5.0 -125 μg/mL MIC values (Table 3).…”