Three new dioxopiperazine metabolites from a marine-derived fungus <i>Aspergillus fumigatus</i> Fres.

Wen, Zhao; Zhu, Tian Jiao; Fan, Guo Tao; Liu, Hong Bing; Fang, Yu Chun; Gu, Qian Qun; Zhu, Wei

doi:10.1080/14786410902726134

Cited by 32 publications

(11 citation statements)

References 9 publications

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“…The study reported for the first time the bioactivity of a marine-derived A. fumigatus against T. congolense. Previous studies reported the isolation of A. fumigatus from macroalgae, sea sediment, and holothurians, and showed to produce several cytotoxic compounds such as N-acetyltyramine (Zhao et al 2010) and the apoptosis-inducing metabolite fumigaclavine C (Li et al 2013). Moreover, Furtado et al (2005) also reported that A. fumigatus derived from soil samples produced metabolites that are bioactive against T. cruzi, which causes Chagas disease.…”

Section: Marine Aspergillimentioning

confidence: 99%

Antibacterial, cytotoxic and trypanocidal activities of marine-derived fungi isolated from Philippine macroalgae and seagrasses

Notarte¹,

Yaguchi²,

Suganuma³

et al. 2018

Acta Botanica Croatica

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The occurrence and bioactivities of marine-derived fungi are evaluated in this paper. A total of 16 morphospecies of marine-derived fungi (MDF) were isolated from four host macroalgae and two seagrasses and identified as belonging to the genera Aspergillus, Fusarium, Paecilomyces, Penicillium, Sclerotinia, Thamnidium and Trichoderma, including five mycelia sterilia. Among these host organisms, the rhodophyte Laurencia intermedia harboured the highest number of isolated MDF. Selected MDF were then assayed and showed to inhibit Pseudomonas aeruginosa (8-19 mm zone of inhibition) and Staphylococcus aureus (6-19 mm zone of inhibition), and were cytotoxic against the brine shrimp Artemia salina nauplii (LD50: 201.56-948.37 μg mL−1). The screening led to the selection of five of the most bioactive morphospecies, all belonging to the genus Aspergillus. These marine aspergilli were subjected to β-tubulin gene sequence analysis for species identification, and to mass production in different culture media with or without marine salts, and screening of the crude culture extracts for their cytotoxic and trypanocidal activities. Aspergillus tubingensis cultivated in potato dextrose broth with marine salt proved to be the most cytotoxic against P388 (IC50: 1028 ng mL−1) and HeLa (IC50: 1301 ng mL−1) cancer cells. On the other hand, A. fumigatus cultivated in malt extract broth without marine salt was shown to be the most potent against Trypanosoma congolense (IC50: 298.18 ng mL−1). Our study therefore showed that salinity may influence the bioactivities of some species of MDF.

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Section: Marine Aspergillimentioning

confidence: 99%

Antibacterial, cytotoxic and trypanocidal activities of marine-derived fungi isolated from Philippine macroalgae and seagrasses

Notarte¹,

Yaguchi²,

Suganuma³

et al. 2018

Acta Botanica Croatica

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“…Marine fungi produce unique and biologically active secondary metabolites (Zhao et al 2010;Deng et al 2013;Suciati et al 2013). As part of our continuous study of the secondary metabolites from marine fungi, marine sponge samples were collected from the Xisha Islands of China.…”

Section: Introductionmentioning

confidence: 99%

A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3

Wang

et al. 2014

Natural Product Research

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(2014) A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3, Natural Product Research: Formerly Natural Product Letters, 28:14, 1070-1074, DOI: 10.1080/14786419.2014 To link to this article: http://dx.doi.org/10.1080/14786419.2014.905935 PLEASE SCROLL DOWN FOR ARTICLETaylor & Francis makes every effort to ensure the accuracy of all the information (the "Content") contained in the publications on our platform. However, Taylor & Francis, our agents, and our licensors make no representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of the Content. Any opinions and views expressed in this publication are the opinions and views of the authors, and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content should not be relied upon and should be independently verified with primary sources of information. Taylor and Francis shall not be liable for any losses, actions, claims, proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or howsoever caused arising directly or indirectly in connection with, in relation to or arising out of the use of the Content.This One new naphthalene derivative, 1,8-dihydroxynaphthol-1-O-a-L-rhamnopyranoside (1), together with one known a-dibenzopyrone, alternariol (2), and five xanthones (3 -7) were isolated from the sponge-derived fungus Arthrinium sp. ZSDS1-F3. All the isolated compounds (1 -7) were established by comprehensive analysis of the spectral data, especially 1D and 2D NMR (HMQC and HMBC) spectra. In the primary bioassays, compound 3 exhibited moderate COX-2 inhibition, with IC 50 values of 12.2 mM.article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is

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“…The EtOAc extract was subjected to a series of solvent/solvent partitioning steps to afford compounds 1 – 12 (Figure 1). Three new structures were identified by the combination of spectroscopic analysis, high-resolution electrospray mass spectrometry (HRESIMS), and electronic circular dichroism (ECD) calculation, while twelve known analogues were identified as bisdethiobis (methylthio)gliotoxin ( 4 ) [10,11], 6-acetylbis(methylthio)gliotoxin ( 5 ) [9,12], 6-deoxy-5a,6-didehydrogliotoxin ( 6 ) [13], 5a,6-didehydrogliotoxin ( 7 ) [14], 6-(phenylmethyl)-(3 R ,6 R )-2,5-piperazinedione ( 8 ) [15], 3-(hydroxymethyl)-3,6-bis(methylthio)-6-(phenylmethyl)-(3 R ,6 R )-2,5-piperazinedione ( 9 ) [15], 3-(hydroxymethyl)-6-(methoxyl)-6-(phenylmethyl)-(3 R ,6 R )-2,5-piperazinedione ( 10 ) [16], 5a,6-anhydrobisdethiobis(methylthio)gliotoxin ( 11 ) [17], and bisdethiobis (methylthio)gliotoxin ( 12 ) [12] by comparison of their spectroscopic data with those in the literature.…”

Section: Resultsmentioning

confidence: 99%

Geospallins A–C: New Thiodiketopiperazines with Inhibitory Activity against Angiotensin-Converting Enzyme from a Deep-Sea-Derived Fungus Geosmithia pallida FS140

Sun

et al. 2018

Marine Drugs

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Three new thiodiketopiperazines, geospallins A–C (1–3), together with nine known analogues (4–12), were isolated from the culture of the deep-sea sediment-derived fungus Geosmithia pallida FS140. Among them, geospallins A and B (1 and 2) represent rare examples of thiodiketopiperazines featuring an S-methyl group at C-10 and a tertiary hydroxyl group at C-11. Their structures were determined by high-resolution electrospray mass spectrometry (HRESIMS), spectroscopic analyses, and electronic circular dichroism (ECD) calculations. Their angiotensin-converting enzyme (ACE) inhibitory activity was reported, and geospallins A–C (1–3) showed inhibitory activity with IC50 values of 29–35 µM.

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Three new dioxopiperazine metabolites from a marine-derived fungus Aspergillus fumigatus Fres.

Cited by 32 publications

References 9 publications

Antibacterial, cytotoxic and trypanocidal activities of marine-derived fungi isolated from Philippine macroalgae and seagrasses

Antibacterial, cytotoxic and trypanocidal activities of marine-derived fungi isolated from Philippine macroalgae and seagrasses

A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3

Geospallins A–C: New Thiodiketopiperazines with Inhibitory Activity against Angiotensin-Converting Enzyme from a Deep-Sea-Derived Fungus Geosmithia pallida FS140

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