Three new diterpenoid alkaloids from the roots of Aconitum duclouxii

Abstract

Three new C₁₉-diterpenoid alkaloids, ducloudines C (1), D (2), and E (3), were isolated from the roots of Aconitum duclouxii. Their structures were established on the basis of extensive spectroscopic analyses. Ducloudine C (1) is the first aconitine-type C₁₉-diterpenoid alkaloid with a C=O group at C-3 and a C=C bond between C-1 and C-2. All compounds were tested for their biological activities against one pathogenic fungi and two pathogenic bacteria.

New Alkaloids from Aconitum stapfianum

“…A hydroxyl group should be located at C-8 according to the HMBC correlations from H-15, H-6 and H-9 to C-8. Additionally, a signal at δ H 3.74 was attributed to H-1 β , suggesting the presence of an OH-1 α [ 7 , 8 ], which was further supported by the ROESY correlation between H-1 and H-5. Therefore, the structure of compound 1 was determined as stapfianine A, with its assigned NMR data listed in Table 1 .…”

Unusual C19-diterpenoid alkaloids from Aconitum vilmorinianum var. patentipilum

“…at d H 4.18 could be assigned to H-14b, suggesting the presence of an alpha hydroxyl group at C-14 (Yin et al, 2014). The methoxyl group could be located at C-16 due to the HMBC correlation of methoxyl hydrogen (d H 3.26, 3H, s) with C-16 (d C 81.8 d).…”

“…Among them, more than 200 species are endemic to China (Xiao et al, 2006). The tubers of 76 Aconitum species are clinically used for treatment of arthritic pain, rheumatic, and neurological disorders in China (Xiong et al, 2008;Yin et al, 2013). Aconitum vilmorinianum var.…”

Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch

“…On the basis of the literature data, the known compounds were determined as songorine ( 2 ) [19], napelline ( 3 ) [20, 21], ducloudine C ( 4 ) [22], aconine ( 5 ) [23], magnoflorine ( 6 ) [24].…”