Three new physalins from Physalis alkekengi var. franchetii

Xu, Wan-xuan; Chen, Jianchao; Liu, Jie‐Qing; Zhou, Lin; Wang, Yifen; Qiu, Ming‐Hua

doi:10.1007/s13659-013-0021-z

Cited by 12 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only three neophysalins, namely 3- O -methylphysalin X ( 388 ), 127 physalin VI ( 389 ), 125 and 5α-hydroxy-7-dehydro-25,27-dihydro-7-deoxyneophysalin A ( 390 ), 123 were reported in the period reviewed. Not unexpectedly, all of them were isolated from Physalis alkekengi var.…”

Section: Phytochemical Investigationsmentioning

confidence: 99%

Natural withanolides, an update

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Phytochemical Investigationsmentioning

confidence: 99%

Natural withanolides, an update

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Physalis (L.) species contains various carbohydrates, lipids, minerals, vitamins and phytosteroles (Sharma et al, 2015). This genus contains calystegins, alkaloids from nortropane, and steroidal glycoalcalkaloids from spirosolane (Jouzier et al, 2005;Xu et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Phytochemical and zootechnical studies of Physalis peruviana L. leaves exposured to streptozotocin-induced diabetic rats

Fokunang¹,

Mushagalusa²,

Tembe-Fokunang³

et al. 2017

J. Pharmacognosy Phytother.

View full text Add to dashboard Cite

This is a phytochemical and zootechnical study on Physalis peruviana leaves in streptozotocin induced diabetic rats. This was part of a scientific development program of plant resources used in Congolese traditional medicine for the treatment of diabetes mellitus in which individual and community consequences are well established. Different fractions with hexane, ethyl acetate and the residue were obtained from the hydroalcoholic extract of P. peruviana leaves. Phytochemical screening was focused on the usual reactions of characterization based on precipitation and coloration with general reagents. The diabetic conditions were induced in rats by a single administration of streptozotocin (50 mg/kg body weight) intravenously. The positive control group received glibenclamide (6.5 mg/kg body weight) and each test group received 100 mg/kg of body weight. Those groups were compared with a control group which received only a Tween 20 solution (1 ml per 100 g body weight). Zootechnical profiles were evaluated by weight monitoring as well as food and water consumption in rats. Phytochemical screening showed the presence of polyphenols, flavonoids, alkaloids, saponins, tannins, anthocyanins, mucilages, cardiac glycosides, coumarins and betalains in the hydroalcoholic extract and its fractions. A highly significant difference (P ˂ 0.001) of water consumption in opposition to the food intake and weight changes was observed. This study suggested the isolation and characterization of compounds from hydroalcoholic extract from the leaves of P. peruviana L. and its fractions for an extensive antidiabetic investigation.

show abstract

“…Frag-B is comprised of four parts, where 27-C and 14-OH are likely to form rings or annular structures. Physalins are mainly found in plants of the genus Physalis ( Li et al, 2014 ; Wu et al, 2020 ; Xu et al, 2013 ), and they are biologically active, that is, they can inhibit tumor growth ( Zhu et al, 2016 ), suppress lymphocyte proliferation ( Ding et al, 2020 ), and inhibit inflammatory processes ( Wu et al, 2012 ). Physalins are a potential source of targeted drug libraries due to their variety and complexity in structures and types of compounds.…”

Section: Introductionmentioning

confidence: 99%

Discovery of physalin biosynthesis and structure modification of physalins in Physalis alkekengi L. var. Franchetii

Gan

Cheng

et al. 2022

Front. Plant Sci.

View full text Add to dashboard Cite

Physalins, active ingredients from the Physalis alkekengi L. var. franchetii (P. alkekengi) plant, have shown anti-inflammatory, antioxidant and anticancer activities. Whereas the bioactivity of physalins have been confirmed, their biosynthetic pathways, and those of quite a few derivatives, remain unknown. In this paper, biosynthesis and structure modification-related genes of physalins were mined through transcriptomic and metabolomic profiling. Firstly, we rapidly and conveniently analyzed physalins by UPLC-Q-TOF-MS/MS utilizing mass accuracy, diagnostic fragment ions, and common neutral losses. In all, 58 different physalin metabolites were isolated from P. alkekengi calyxes and berries. In an analysis of the physalin biosynthesis pathway, we determined that withanolides and withaphysalins may represent a crucial intermediate between lanosterol and physalins. and those steps were decanted according to previous reports. Our results provide valuable information on the physalin metabolites and the candidate enzymes involved in the physalins biosynthesis pathways of P. alkekengi. In addition, we further analyzed differential metabolites collected from calyxes in the Jilin (Daodi of P. alkekengi) and others. Among them, 20 physalin metabolites may represent herb quality biomarkers for Daodi P. alkekengi, providing an essential role in directing the quality control index of P. alkekengi.

show abstract

Three new physalins from Physalis alkekengi var. franchetii

Cited by 12 publications

References 21 publications

Natural withanolides, an update

Natural withanolides, an update

Phytochemical and zootechnical studies of Physalis peruviana L. leaves exposured to streptozotocin-induced diabetic rats

Discovery of physalin biosynthesis and structure modification of physalins in Physalis alkekengi L. var. Franchetii

Contact Info

Product

Resources

About