The genus Rhodomyrtus (Myrtaceae) consists of 17 species, which are native to Asia, Malesia, Melanesia, and Australia.
1,2During the past few years, a number of unusual phloroglucinol derivatives such as rhodomyrtone, 3 rhodomyrtosones, 4 and tomentosones, 5 have been isolated from Rhodomyrtus tomentosa. Among them, rhodomyrtone displayed potent anti-bacterial activity, especially against methicillin-resistant Staphylococcus aureus.6 In our efforts to discover natural products with potential application in wound healing, we have examined the Australian endemic species Rhodomyrtus psidioides (G. Don) Benth. This species, commonly called native guava, is a shrub or small rainforest tree, which grows up to 12 m high, native to eastern Australia.7 Chemical investigations of the leaves of this plant led to the isolation of four novel compounds (1-4) (Fig. 1) that possess two new phloroglucinolcoupled eudesmane skeletons, as well as the known compound eucalyptin A (5). Herein, details of the isolation, structural elucidation, and antibacterial activity of the rhodomyrtals A-D (1-4) are described. .5] as well as an oxygenated carbon at d C 71.3. The aforementioned data suggested a phloroglucinol-coupled sesquiterpenoid for compound 1. The above mentioned functionalities accounted for 7 out of the 9 double-bond equivalents, which indicated the presence of two rings in compound 1. The key HMBC correlations (Fig. 2)