Three new sulphur glycosides from the seeds of <i>Descurainia sophia</i>

Feng, Weisheng; Li, Chunge; Zheng, Xiaoke; Li, Lingling; Chen, Wenjing; Cao, Yan-Gang; Gong, Jian; Kuang, Hai‐Xue

doi:10.1080/14786419.2015.1135141

Cited by 15 publications

(6 citation statements)

References 11 publications

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“…Alcohol C2AlcS should be easily obtained by reduction of the syringyl derivative of C2AldG , and it has been reported as product from lignin depolymerization. Raphanuside ( PN10 ) can be found in Descurainia sophia and was used for anticough and antiasthmatic purposes and moreover show anticancer activity, and it can be synthesized from C2AlcS in eight steps. , …”

Section: Compounds With Pharmacological Activity From Lignin-derived ...mentioning

confidence: 99%

Bright Side of Lignin Depolymerization: Toward New Platform Chemicals

et al. 2018

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Lignin, a major component of lignocellulose, is the largest source of aromatic building blocks on the planet and harbors great potential to serve as starting material for the production of biobased products. Despite the initial challenges associated with the robust and irregular structure of lignin, the valorization of this intriguing aromatic biopolymer has come a long way: recently, many creative strategies emerged that deliver defined products via catalytic or biocatalytic depolymerization in good yields. The purpose of this review is to provide insight into these novel approaches and the potential application of such emerging new structures for the synthesis of biobased polymers or pharmacologically active molecules. Existing strategies for functionalization or defunctionalization of lignin-based compounds are also summarized. Following the whole value chain from raw lignocellulose through depolymerization to application whenever possible, specific lignin-based compounds emerge that could be in the future considered as potential lignin-derived platform chemicals.

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Section: Compounds With Pharmacological Activity From Lignin-derived ...mentioning

confidence: 99%

Bright Side of Lignin Depolymerization: Toward New Platform Chemicals

et al. 2018

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“…The extract ratio of the five fractions (DS-Pol/DS-Oli/DS-FG/DS-FA/DS-FO) were: 1.231%, 1.306%, 0.289%, 0.517%, 28.8%. DS and its fractions were isolated systematically, purified and identified accurately in the previous phytochemical studies described by Feng and his colleagues ( Gong et al, 2014 ; Feng et al, 2015 ; Feng et al, 2016 ). The chemical profiles of DS and its fractions were characterized by our team through HPLC combined with three detectors (PDA/ELSD/UV) and LC-MS analysis to guarantee stability and reproducibility of the fraction-splitting method and non-overlapping property of different fractions ( Zhang, 2015 ; Zhou et al, 2017 ).…”

Section: Methodsmentioning

confidence: 99%

Protective effects of Descurainia sophia seeds extract and its fractions on pulmonary edema by untargeted urine and serum metabolomics strategy

et al. 2023

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Background:Descurainia sophia seeds (DS) is a herbal medicine in traditional Chinese medicine (TCM) for treating lung diseases. We aimed to evaluate the therapeutic effect of DS and five of its fractions upon pulmonary edema (PE) through metabolomics analysis (MA) of urine and serum samples of rats.Methods: A PE model was established by intrathoracic injection of carrageenan. Rats were pretreated with DS extract or its five fractions (polysaccharides (DS-Pol); oligosaccharides (DS-Oli); flavonoid glycosides (DS-FG); flavonoid aglycone (DS-FA); fat oil fraction (DS-FO)) for seven consecutive days. Forty-eight hours after carrageenan injection, lung tissues were subjected to histopathology. MA of urine and serum was done by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry, respectively. Principal component analysis and orthogonal partial least squares-discriminant analysis were operated for the MA of rats and potential biomarkers related to treatment. Heatmaps and metabolic networks were constructed to explore how DS and its five fractions act against PE.Results: DS and its five fractions could all attenuate pathologic lung injury to different degrees, and DS-Oli, DS-FG, and DS-FO had a more potent effect compared with DS-Pol and DS-FA. DS-Oli, DS-FG, DS-FA, and DS-FO could regulate the metabolic profiles of PE rats, but DS-Pol was less potent. According to MA, the five fractions could improve PE to some degree due to their anti-inflammatory, immunoregulatory, and renoprotective activities by mediating the metabolism of taurine, tryptophan, and arachidonic acid. However, DS-Oli, DS-FG, and DS-FO had more important roles in edema-fluid reabsorption, and reduction of vascular leakage through regulating the metabolism of phenylalanine, sphingolipid and bile acid. Finally, heatmaps and hierarchical clustering analysis indicated DS-Oli, DS-FG, and DS-FO to be more efficacious than DS-Pol or DS-FA against PE. The five fractions of DS had a synergistic effect on PE from different aspects, thereby constituting the entire efficacy of DS. DS-Oli, DS-FG, or DS-FO could be used as an alternative to DS.Conclusion: MA combined with use of DS and its fractions provided novel insights into the mechanism of action of TCM.

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“…However, they have both been used as “Tinglizi”; there were distinctions between their plant origin, appearance, and pharmacological activity [ 4 ]. Compared with the seeds of L. apetalum , the previous investigations of Sophia D. semen were more comprehensive [ 5 , 6 , 7 , 8 ]. Modern pharmacology has demonstrated that the seeds of L. apetalum have a cardiotonic [ 9 ] effect and the chemical constituents were mainly flavonoids [ 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Four New Benzoylamide Derivatives Isolated from the Seeds of Lepidium apetalum Willd. and Ameliorated LPS-Induced NRK52e Cells via Nrf2/Keap1 Pathway

Zhang

Zeng

et al. 2022

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Four new benzoylamide derivatives,lepidiumamide B–E (1–4), were isolated from the seeds of Lepidium apetalumWilld. The structures were determined by a combination of MS and NMR analyses. All compounds were evaluated for their protective effects against NRK-52e cell injury induced by lipopolysaccharide (LPS) in vitro. These compounds showed significantly protective activity and ameliorated LPS-induced NRK52e cells via the Nrf2/Keap1 pathway. The discovery of these active compounds is important for the prevention and treatment of renalinjury.

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Three new sulphur glycosides from the seeds of Descurainia sophia

Cited by 15 publications

References 11 publications

Bright Side of Lignin Depolymerization: Toward New Platform Chemicals

Bright Side of Lignin Depolymerization: Toward New Platform Chemicals

Protective effects of Descurainia sophia seeds extract and its fractions on pulmonary edema by untargeted urine and serum metabolomics strategy

Four New Benzoylamide Derivatives Isolated from the Seeds of Lepidium apetalum Willd. and Ameliorated LPS-Induced NRK52e Cells via Nrf2/Keap1 Pathway

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