Three novel Ni(II), VO(II) and Cr(III) mononuclear complexes encompassing potentially tridentate imine ligand: Synthesis, structural characterization, DNA interaction, antimicrobial evaluation and anticancer activity

Abstract

Three novel Cr(III),VO(II) and Ni(II) imine complexes derived from the condensation of 2‐aminophenol (AP) with 2‐hydroxynaphthaldehyde (HN) were synthesized. The prepared HNAP imine ligand and its complexes were investigated via various physicochemical tools. The results suggest that the parent ligand behaves as a dibasic tridentate ONO ligand, when coordinated to Cr(III) in octahedral and to Ni(II) in tetrahedral geometry. In the case of VO(II), it coordinates in distorted square pyramidal geometry. Also, the prepared compounds were screened for their antimicrobial activities against pathogenic bacteria, Escherichia coli (−ve), Bacillus subtilis (+ve) and Staphylococcus aureus (+ve), and some types of fungi, Aspergillus niger, Candida glabrata and Trichophyton rubrum. The results indicate that the complexes show a stronger antimicrobial efficiency compared to the pro‐ligand. The interaction of the prepared complexes with calf thymus DNA was investigated using spectral, viscosity and gel electrophoresis measurements. The obtained results clearly demonstrate that the binding affinity with calf thymus DNA follows the order HNAPCr > HNAPV > HNAPNi. The cytotoxic activity of the prepared compounds on human colon carcinoma cells (HCT‐116 cell line), hepatic cellular carcinoma cells (HepG‐2cell line) and breast carcinoma cells (MCF‐7cell line) was examined. From these results it is found that the investigated complexes have potent cytotoxicity against growth of carcinoma cells compared to the corresponding imine pro‐ligand.

Spectroscopic, textural, electrical and magnetic properties of antimicrobial nano Fe(III) Schiff base complex

“…[1][2][3] The absorption band of the C=O in the dibenzoylmethane at 1700 cm −1 persisedt even after the formation of the Schiff base ligand where the infrared spectrum of the ligand showed a stretching frequency at 1680 cm −1 , which confirmed that one of the two C=O groups only participated in the condensation. The vibrational assignments were aided by comparison with the vibrational frequencies of the related compounds.…”

“…[1][2][3] The vibration bands of ν(C=O) and ν(NH 2 ) that lay at 1680 and 3380 cm −1 at the parent ligand, respectively, were shifted to 1685 and 3312 cm −1 , respectively. This phenomenon appeared because of the coordination of azomethine nitrogen to ferric ion.…”

“…The 3 ]Cl 3 complex was thermally decomposed in four successive steps. The first estimated mass loss of 7.03% (calcd 6.77%) within the temperature range of 100-145°C with maximum temperature at 122°C may be attributed to the liberation of two molecules of coordinated water.…”

“…[1][2][3] Their structures can be altered by changing the organic and inorganic entities, and hence new functional materials of tailored properties can be generated. [1][2][3] Their structures can be altered by changing the organic and inorganic entities, and hence new functional materials of tailored properties can be generated.…”

Oxotitanium(IV) complexes of some bis‐unsymmetric Schiff bases: Synthesis, structural elucidation and biomedical applications

“…[2] Nowadays, the research on Schiff bases is increasing due to their ease of synthesis, structural variety, varied coordinating ability, thermal stability and catalytic activities. [5][6][7][8][9][10][11] An unsymmetric tridentate Schiff base ligand, 2-(2-nitrophenylthio)-N-((pyridine-2-yl) methylene)benzenamine, and its Mn(II), Ni(II), Cu(II) and Zn(II) complexes were synthesized and characterized using various physicochemical and spectroscopic techniques and crystal X-ray diffraction. [5][6][7][8][9][10][11] An unsymmetric tridentate Schiff base ligand, 2-(2-nitrophenylthio)-N-((pyridine-2-yl) methylene)benzenamine, and its Mn(II), Ni(II), Cu(II) and Zn(II) complexes were synthesized and characterized using various physicochemical and spectroscopic techniques and crystal X-ray diffraction.…”