Three‐parameter shear wave inversion in MR elastography of incompressible transverse isotropic media: Application to in vivo lower leg muscles

Guo, Jing; Hirsch, Sebastian; Scheel, Michael; Braun, Jürgen; Sack, Ingolf

doi:10.1002/mrm.25740

Cited by 50 publications

(68 citation statements)

References 43 publications

(85 reference statements)

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“…Recent advances in MRE have led to the development of anisotropic inversion methods that utilize DTI to identify the primary fiber direction in the muscle and which has been incorporated into MRE data analysis 69. A recent study has also employed a three‐parameter inversion method to measure the anisotropic shear elastic parameters of skeletal muscle 71. In addition, it should be noted that the EIMD protocol was designed to produce muscle damage regardless of the strength of the individual participants on account of a personalized workload having been set based on peak eccentric and concentric forces measured over three trials.…”

Section: Discussionmentioning

confidence: 99%

MR elastography measurement of the effect of passive warmup prior to eccentric exercise on thigh muscle mechanical properties

Kennedy

Macgregor

Barnhill

et al. 2017

Magnetic Resonance Imaging

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PurposeTo investigate the effect of warmup by application of the thermal agent Deep Heat (DH) on muscle mechanical properties using magnetic resonance elastography (MRE) at 3T before and after exercise‐induced muscle damage (EIMD).Materials and MethodsTwenty male participants performed an individualized protocol designed to induce EIMD in the quadriceps. DH was applied to the thigh in 50% of the participants before exercise. MRE, T 2‐weighted MRI, maximal voluntary contraction (MVC), creatine kinase (CK) concentration, and muscle soreness were measured before and after the protocol to assess EIMD effects. Five participants were excluded: four having not experienced EIMD and one due to incidental findings.ResultsTotal workload performed during the EIMD protocol was greater in the DH group than the control group (P < 0.03), despite no significant differences in baseline MVC (P = 0.23). Shear stiffness |G*| increased in the rectus femoris (RF) muscle in both groups (P < 0.03); however, DH was not a significant between‐group factor (P = 0.15). MVC values returned to baseline faster in the DH group (5 days) than the control group (7 days). Participants who displayed hyperintensity on T 2‐weighted images had a greater stiffness increase following damage than those without: RF; 0.61 kPa vs. 0.15 kPa, P < 0.006, vastus intermedius; 0.34 kPa vs. 0.03 kPa, P = 0.06.ConclusionEIMD produces increased muscle stiffness as measured by MRE, with the change in |G*| significantly increased when T 2 hyperintensity was present. DH did not affect CK concentration or soreness; however, DH participants produced greater workload during the EIMD protocol and exhibited accelerated MVC recovery. Level of Evidence: 1 Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2017;46:1115–1127.

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Section: Discussionmentioning

confidence: 99%

MR elastography measurement of the effect of passive warmup prior to eccentric exercise on thigh muscle mechanical properties

Kennedy

Macgregor

Barnhill

et al. 2017

Magnetic Resonance Imaging

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“…An ITI material is fully described using three parameters (13,17,18), which can be a combination of two tensile moduli ( E 1 and E 2 ) and two shear moduli ( μ 1 and μ 2 ). Here the tensile modulus is defined as E 1 and the shear modulus is defined as μ 1 .…”

Section: Theorymentioning

confidence: 99%

“…Table 1 provides a comparison of the material properties used by both Tweten et al (18) and Guo et al (17), see Appendix A for more details.…”

Section: Theorymentioning

confidence: 99%

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Requirements for accurate estimation of anisotropic material parameters by magnetic resonance elastography: A computational study

Tweten

Okamoto

Bayly

2017

Magnetic Resonance in Med

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Purpose Establish the essential requirements for characterization of a transversely isotropic material by magnetic resonance elastography (MRE). Theory and Methods Three methods for characterizing nearly incompressible, transversely isotropic (ITI) materials were used to analyze data from: closed-form expressions for traveling waves; finite element (FE) simulations of waves in homogeneous ITI material; and FE simulations of waves in heterogeneous material. Key properties are the complex shear modulus μ2, shear anisotropy ϕ = μ1/μ2 − 1, and tensile anisotropy ζ = E1/E2 − 1. Results Each method provided good estimates of ITI parameters when both slow and fast shear waves with multiple propagation directions were present. No method gave accurate estimates when the displacement field contained only slow shear waves, only fast shear waves, or waves with only a single propagation direction. Methods based on directional filtering are robust to noise and include explicit checks of propagation and polarization. Curl-based methods led to more accurate estimates in low noise conditions. Parameter estimation in heterogeneous materials is challenging for all methods. Conclusion Multiple shear waves, both slow and fast, with different propagation directions, must be present in the displacement field for accurate parameter estimates in ITI materials. Experimental design and data analysis can ensure these requirements are met.

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“…The potential of SWE to detect tissue anisotropy was previously shown for in-vitro tissue phantoms (Chatelin et al, 2014;Aristizabal et al, 2014) for skeletal and cardiac muscle (Gennisson et al, 2010;Urban et al, 2016;Rudenko & Sarvazyan, 2006;Pernot et al, 2007) and kidneys (Amador et al, 2011). However, most of the studies in literature have mainly focused on bulky transverse isotropic materials with only one family of fibres (Rudenko & Sarvazyan, 2006;Gennisson et al, 2010;Royer et al, 2011;Rudenko & Sarvazyan, 2014;Chatelin et al, 2015;Urban et al, 2016;Guo et al, 2015;Chatelin et al, 2014). Arterial layers consist of (minimally) two families of collagen fibres with different orientations which lends them an orthotropic and nonlinear response.…”

Section: Numerical Model -Agreement With Experimental Datamentioning

confidence: 99%

A finite element model to study the effect of tissue anisotropy onex vivoarterial shear wave elastography measurements

Shcherbakova¹,

Debusschere²,

Caenen³

et al. 2017

Phys. Med. Biol.

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Abstract. Shear wave elastography (SWE) is an ultrasound (US) diagnostic method for measuring the stiffness of soft tissues based on generated shear waves (SWs). SWE has been applied to bulk tissues, but in arteries it is still under investigation. Previously performed studies in arteries or arterial phantoms demonstrated the potential of SWE to measure arterial wall stiffness -a relevant marker in prediction of cardiovascular diseases. This study is focused on numerical modelling of SWs in ex vivo equine aortic tissue, yet based on experimental SWE measurements with the tissue dynamically loaded while rotating the US probe to investigate the sensitivity of SWE to the anisotropic structure. A good match with experimental shear wave group speed results was obtained. SWs were sensitive to the orthotropy and nonlinearity of the material. The model also allowed to study the nature of the SWs by performing 2D FFT-based and analytical phase analyses. A good match between numerical group velocities derived using the time-of-flight algorithm and derived from the dispersion curves was found in the cross-sectional and axial arterial views. The complexity of solving analytical equations for nonlinear orthotropic stressed plates was discussed.

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Three‐parameter shear wave inversion in MR elastography of incompressible transverse isotropic media: Application to in vivo lower leg muscles

Abstract: Recovery of the full elasticity tensor in incompressible TI materials is feasible by three-dimensional inversion of the time-harmonic shear wave equation. The method is potentially useful for the clinical evaluation of skeletal muscle anisotropy.

Cited by 50 publications

References 43 publications

MR elastography measurement of the effect of passive warmup prior to eccentric exercise on thigh muscle mechanical properties

MR elastography measurement of the effect of passive warmup prior to eccentric exercise on thigh muscle mechanical properties

Requirements for accurate estimation of anisotropic material parameters by magnetic resonance elastography: A computational study

A finite element model to study the effect of tissue anisotropy onex vivoarterial shear wave elastography measurements

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