Three patients with desmoplastic tricholemmoma with an incidental histological surprise impacting on management: Figure 1

Ung, Tsiang; Tan, Jennifer; Mudhar, Hardeep Singh

doi:10.1136/bjo.2010.187856

Cited by 5 publications

(17 citation statements)

References 9 publications

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“…We identified 19 publications worldwide reporting a total of 81 distinct individual cases of DT. 1,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Epidemiology…”

Section: Literature Reviewmentioning

confidence: 99%

Desmoplastic Trichilemmoma—A Report of Successful Treatment with Mohs Micrographic Surgery and a Review and Update of the Literature

Afshar

Lee

Jiang

2012

Dermatologic Surgery

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“…We identified 19 publications worldwide reporting a total of 81 distinct individual cases of DT. 1,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Epidemiology…”

Section: Literature Reviewmentioning

confidence: 99%

Desmoplastic Trichilemmoma—A Report of Successful Treatment with Mohs Micrographic Surgery and a Review and Update of the Literature

Afshar

Lee

Jiang

2012

Dermatologic Surgery

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“…To the authors' knowledge, there have been only 11 cases reported previously in the literature involving the eyelids. [3][4][5][6][7][8][9][10][11] This study adheres to the principles of the Declaration of Helsinki and is Health Insurance Portability and Accountability Act compliant.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9][10][11] Eighty-three percent of reported DTs localized to the eyelids were identified in men with a mean age of 61.2 years (range, 51-71 years). The majority (62.5%) were located on the upper eyelid, with the average size being 6.2 mm (range, 4-11 mm).…”

Section: Discussionmentioning

confidence: 99%

“…Eleven cases have been reported from lesions outside the face and scalp, while an additional 4 lesions did not have a reported location. [1][2][3][4][5][6][7][8][9][10][11][12] The most common preoperative diagnoses were BCC and papilloma. With a diagnosis of desmoplastic or other trichilemmoma variants, Cowden disease, or multiple hamartoma syndrome, should be considered.…”

Section: Discussionmentioning

confidence: 99%

“…Two were found in continuity with DT, while 2 arose in a discontiguous fashion. 12 Ung et al 10 reported 3 cases of eyelid DTs associated with BCC (all on the lower eyelid) and recommended that any biopsy-proven DT should be managed with wide margin excision to ensure complete clearance and to excise any potential coexisting BCC.…”

Section: Eyelid Desmoplastic Trichilemmoma: 2 Case Reports and Reviewmentioning

confidence: 98%

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Eyelid Desmoplastic Trichilemmoma

Pihlblad

Chelnis

Schaefer

2014

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Desmoplastic trichilemmomas (DTs) are a rare variant of trichilemmomas first described in 1985. Since then, 11 cases involving the eyelid have been reported. Two cases of this study raise this total to 13. DTs are often clinically confused with basal cell carcinoma and must be proven by biopsy to obtain the correct diagnosis. These lesions are more commonly present in patients older than 50 years. Despite the fact that they are benign, they are often associated with basal cell carcinomas and as such should be managed carefully, requiring excisional biopsy with frozen borders or Mohs controlled margins.

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Use of Cytokeratin 17 in the Differentiation Between Desmoplastic Trichilemmoma and Cutaneous Basal Cell Carcinoma

Chaudet

Stagner

Nazarian

2022

The American Journal of Dermatopathology

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:Desmoplastic trichilemmoma (DTL) is a variant of trichilemmoma characterized by a prominent desmoplastic stroma that may mimic invasive carcinoma. These lesions typically show features of a conventional trichilemmoma at the periphery, surrounding dense hyalinized stroma with entrapped cords of tumor cells. On a small or superficial biopsy, DTL may pose a diagnostic challenge in distinguishing this benign adnexal neoplasm from invasive carcinoma, particularly basal cell carcinoma (BCC). We aimed to investigate whether the immunohistochemical expression of cytokeratin 17 (CK17) would be useful in the differentiation between DTL and BCC. CK17 is expressed in normal adnexal structures and has been shown to demonstrate strong staining in BCCs. Expression of CK17 was examined in 23 cases of DTL and 23 BCCs. An immunoreactivity score was assigned using the percentage of tumor cells staining with scoring as follows: 0, complete negativity; 1, < 15% tumor cells staining; 2, 15%–84% tumor cells staining; and 3, >85% staining. All cases of BCC scored as 3, whereas 18% of DTL scored as 3. The mean percent staining for CK17 was significantly higher for BCCs (97% of tumor cells) than DTLs (57% of tumor cells); P < 0.001 in the unpaired t test. The pattern of CK17 staining may also help differentiate between cases scoring 3. All BCCs showed strong diffuse staining throughout, whereas for those cases of DTL with a score of 3, the peripheral basaloid rim in the tumor lobules did not stain. CK17 is a useful adjunct in distinguishing DTL from BCC in small or superficial biopsy specimens.

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Three patients with desmoplastic tricholemmoma with an incidental histological surprise impacting on management: Figure 1

Cited by 5 publications

References 9 publications

Desmoplastic Trichilemmoma—A Report of Successful Treatment with Mohs Micrographic Surgery and a Review and Update of the Literature

Desmoplastic Trichilemmoma—A Report of Successful Treatment with Mohs Micrographic Surgery and a Review and Update of the Literature

Eyelid Desmoplastic Trichilemmoma

Use of Cytokeratin 17 in the Differentiation Between Desmoplastic Trichilemmoma and Cutaneous Basal Cell Carcinoma

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