Three structurally related Copper complexes with two isomers: DNA/BSA binding ability, DNA cleavage activity and excellent cytotoxicity

Zhang, Dongyan; Nie, Yan; Sang, Hui; Suo, Jing-Jing; Li, Zong-Jin; Gu, Wen; Tian, Jin‐Lei; Liu, Xin; Shi, Yan

doi:10.1016/j.ica.2016.12.002

Cited by 27 publications

(13 citation statements)

References 69 publications

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“…Since many of the halido-Cu(II) complexes are now extensively used to mimic biological systems, especially those derived from tripodal and linear tetraamine coligands (N4), [Cu(N4)X] + in DNA cleavage and the cytotoxicity studies as potential anticancer agents [ 4 , 5 , 6 , 7 , 8 , 49 , 50 , 51 , 52 ], it is worthwhile to shed the light on the behavior of this class of compounds in solutions in order check the validity of geometrical structures at the two levels. The data compiled in Table 3 reveals that increasing the steric crowding at the TPA through successive methylation at the 6th position of the pyridyl groups resulted in the conversion from perfect TBP geometry as in [Cu(TPA)Cl] + to distorted SP in [Cu(6-MeTPA)Cl] + and [Cu(6-Me 2 TPA)Cl] + , and to intermediate geometry in the most sterically hindered [Cu(6-Me 3 TPA)Cl] + complex ion ( Table 3 : compounds 42 – 46 ), a result which was unexpected.…”

Section: Resultsmentioning

confidence: 99%

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Five-Coordinated Geometries from Molecular Structures to Solutions in Copper(II) Complexes Generated from Polydentate-N-Donor Ligands and Pseudohalides

et al. 2020

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A novel series of mononuclear five-coordinated pseudohalido-Cu(II) complexes displaying distorted square bipyramidal: [Cu(L1)(NCS)2] (1), [Cu(L2)(NCS)2] (2) and [Cu(L3)(NCS)]ClO4 (5) as well as distorted trigonal bipyramidal: [Cu(isp3tren)(N3)]ClO4 (3), [Cu(isp3tren)(dca)]ClO4 (4) and [Cu(tedmpza)(dca)]ClO4·0.67H2O (6) geometries had been synthesized and structurally characterized using X-ray single crystal crystallography, elemental microanalysis, IR and UV-vis spectroscopy, and molar conductivity measurements. Different N-donor amine skeletons including tridentate: L1 = [(2-pyridyl)-2-ethyl)-(3,4-dimethoxy)-2-methylpyridyl]methylamine and L2 = [(2-pyridyl)-2-ethyl)-(3,5-dimethyl-4-methoxy)-2-methyl-pyridyl]methylamine, and tetradentate: L3 = bis(2-ethyl-di(3,5-dimethyl-1H-pyrazol-1-yl)-[2-(3,4-dimethoxy-pyridylmethyl)]amine, tedmpza = tris[(2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl]amine and isp3tren = tris[(2-isopropylamino)ethyl)]amine ligands were employed. Molecular structural parameters such as nature of coligand, its chelate ring size and steric environment incorporated into its skeleton, which lead to adopting one of the two limiting geometries in these complexes and other reported compounds are analyzed and correlated to their assigned geometries in solutions. Similar analysis were extended to other five-coordinated halido-Cu(II) complexes.

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Section: Resultsmentioning

confidence: 99%

“…TBP in the latter case (compounds 51 – 54 ). Moreover, SP geometries seem to be the most preferable species with bidentate (L 9 ), linear tri-(L 8 ) and tetra-dentate (L 10 ) ligands as these were the cases of complexes 61 – 63 [ 49 , 50 , 51 ].…”

Section: Resultsmentioning

confidence: 99%

Five-Coordinated Geometries from Molecular Structures to Solutions in Copper(II) Complexes Generated from Polydentate-N-Donor Ligands and Pseudohalides

et al. 2020

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“…[11][12][13][14] Furthermore, comparedt op latinum and ruthenium complexes,copper complexes have demonstratedgood antitumor activity with fewer side effects. [20][21][22][23][24] In as imilar fashion, metal complexes with Schiff-base scaffolds have been effectively applied as antibacterial chemotherapeutic moieties in medicine. [20][21][22][23][24] In as imilar fashion, metal complexes with Schiff-base scaffolds have been effectively applied as antibacterial chemotherapeutic moieties in medicine.…”

Section: Introductionmentioning

confidence: 99%

“…[15][16][17][18][19] Moreover,av ariety of pyridine-ligand-based complexes have exhibited high reactivity toward DNA cleavage and cell apoptosis. [20][21][22][23][24] In as imilar fashion, metal complexes with Schiff-base scaffolds have been effectively applied as antibacterial chemotherapeutic moieties in medicine. [25,26] The chemotherapeutic effect of Cu II -containing Schiff-base complexes may be enhanced by tuningt he electronic properties of the metal centero rt he ligandst hrough coordination.…”

Section: Introductionmentioning

confidence: 99%

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Photocytotoxic Copper(II) Complexes with Schiff‐Base Scaffolds for Photodynamic Therapy

Lin

Chiu

Hsu

et al. 2018

Chemistry A European J

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Photodynamic therapy (PDT) is a promising and minimally invasive method for the treatment of superficial diseases, and photosensitizers with high phototoxicity indices (defined as (IC )/(IC )) are essential for the development of ideal photosensitizing properties for this technology. Herein, we report a series of photocytotoxic copper(II) complexes [Cu( QYMP)(dppn)] ( QYMP=N,N,O-tridentate Schiff-base derivatives, dppn=benzo[i]dipyrido[3,2-a;2',3'-c]phenazine), the structures of which have been confirmed by mass spectrometry and FTIR spectroscopy. X-ray crystallography revealed that the CuN O core of the [Cu( QYMP)(dppn)](ClO ) complex (3) has a distorted square-pyramidal geometry. Phototoxicity indices of 329 against human squamous cell carcinoma (SCC15) and 296 against basal cell carcinoma (BCC) cell lines have been determined with [Cu( QYMP)(dppn)](ClO ) (4). This can be attributed to the formation of reactive oxygen species, cell apoptosis, and caspase-3 activation, indicating high potential of complex 4 as a photosensitizer candidate in PDT. Thus, copper complexes bearing suitable Schiff-base ligands with a dppn co-ligand may be considered for the design of efficient metal-based anticancer agents for PDT.

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Supramolecular interaction of transition metal complexes with albumins and DNA: Spectroscopic methods of estimation of binding parameters

Galkina

Проскурнин

2018

Applied Organom Chemis

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Binding parameters of metal complexes with albumins and DNA since the middle of 1990s are considered and summarized. The most widespread spectroscopic methods of estimation of binding parameters are discusseddirect fluorescent methods, indirect fluorescent methods (by fluorescence quenching parameters), and ways of estimation of binding constants by other optical spectroscopic methods. The methods and approaches to calculations used for the determination of binding constants are discussed. The data on the already found binding constants and kinetic parameters is systematized.KEYWORDS albumins, DNA, metal complexes, proteins, supramolecular interaction Funding information: Russian Foundation for Basic Research, Grant/Award Number: 16-03-01089_a 16-53-50027_YaF_a Abbreviations and designations used: F 0 , fluorescence intensity in the absence of a quencher; F, fluorescence intensity in the presence of a acid); NTSC, a new thiosemicarbazone; o-cbiaH, 5-(2-carboxybenzyloxy)isophthalic acid; o-van-gln, a Schiff base derived from o-vanillin and glutamine; o-van-L-met, Schiff base derived from o-vanillin and L-methionine; oxo, 5-

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Three structurally related Copper complexes with two isomers: DNA/BSA binding ability, DNA cleavage activity and excellent cytotoxicity

Cited by 27 publications

References 69 publications

Five-Coordinated Geometries from Molecular Structures to Solutions in Copper(II) Complexes Generated from Polydentate-N-Donor Ligands and Pseudohalides

Five-Coordinated Geometries from Molecular Structures to Solutions in Copper(II) Complexes Generated from Polydentate-N-Donor Ligands and Pseudohalides

Photocytotoxic Copper(II) Complexes with Schiff‐Base Scaffolds for Photodynamic Therapy

Supramolecular interaction of transition metal complexes with albumins and DNA: Spectroscopic methods of estimation of binding parameters

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