Three-year experience of using venovenous extracorporeal membrane oxygenation for patients with severe respiratory failure

Ng, George WY; Leung, Anne Kit Hung; Sin, KC; Au, SY; Chan, Stanley CH; Chan, Osburga PK; Wu, Helen HL

doi:10.12809/hkmj144211

Cited by 6 publications

(8 citation statements)

References 9 publications

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“…Of these 35 selected articles (Table ), only 24 (69%, Table 1) described in‐hospital outcomes (on‐ECMO mortality, weaning rate, in‐hospital mortality after weaning, and discharge rate) in detail, enabling the evaluation and appraisal of the V‐V ECMO gap . Therefore, these 24 articles were used for further analysis of the V‐V ECMO gap 16‐39 . Of note, two separate studies were included by the same author 37,38 describing distinct study groups (patients with trauma and nontrauma).…”

Section: Resultsmentioning

confidence: 99%

Defining and understanding the “extra‐corporeal membrane oxygenation gap” in the veno‐venous configuration: Timing and causes of death

et al. 2021

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In-hospital mortality of adult veno-venous extracorporeal membrane oxygenation (V-V ECMO) patients remains invariably high. However, little is known regarding timing and causes of in-hospital death, either on-ECMO or after weaning. The current review aims to investigate the timing and causes of death of adult patients during hospital admittance for V-V ECMO, and to define the V-V ECMO gap, which is represented by the patients that are successfully weaned of ECMO but still die during hospital stay. A systematic search was performed using electronic MEDLINE and EMBASE databases through PubMed. Studies reporting on adult V-V ECMO patients from January 2006 to December 2020 were screened. Studies that did not report on at least on-ECMO mortality and discharge rate were excluded from analysis as they could not provide the required information regarding the proposed V-V ECMO-gap. Mortality rates on-ECMO and after weaning, as well as weaning and discharge rates, were analyzed as primary outcomes. Secondary outcomes were the causes of death and complications. Initially, 35 studies were finally included in this review. Merely 24 of these studies (comprising 975 patients) reported on prespecified V-V ECMO outcomes (on-ECMO mortality and discharge rate). Mortality on V-V ECMO support was 27.8% (95% confidence interval (CI) 22.5%-33.2%), whereas mortality after successful weaning was 12.7% (95% CI 8.8%-16.6%, defining the V-V ECMO gap).72.2% of patients (95% CI 66.8%-77.5%) were weaned successfully from support and 56.8% (95% CI 49.9%-63.8%) of patients were discharged from hospital. The most common causes of death on ECMO were multiple organ failure, bleeding, and sepsis. Most common causes of death after weaning were multiorgan failure

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Section: Resultsmentioning

confidence: 99%

Defining and understanding the “extra‐corporeal membrane oxygenation gap” in the veno‐venous configuration: Timing and causes of death

et al. 2021

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“…ECMO is currently a standard therapy as respiratory support for patient with severe respiratory failure due to viral or bacterial infection despite conventional ventilator support 20,21 and is available in specialised centres in Hong Kong including Queen Mary Hospital, Pamela Youde Nethersole Eastern Hospital, Queen Elizab eth Hospita l, Prince of Wales Ho spital and Princess Margaret Hospital. ECMO provides effective respiratory (veno-venous-ECMO) and cardiopulmonary support (veno-arterial ECMO) in patients with potentially reversible respiratory or cardiopulmonary failure.…”

Section: Discussionmentioning

confidence: 99%

A Case of Severe Varicella Pneumonia Requiring Extracorporeal Membrane Oxygenation

Tong

Kwan

Chan

2016

Hong Kong Journal of Emergency Medicine

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A 35-year-old male Nigerian suffered from severe varicella pneumonia, which was complicated by severe acute respiratory distress syndrome, acute kidney injury and acute hepatitis. He developed persistent hypoxia despite maximum mechanical ventilation support requiring veno-venous extracorporeal membrane oxygenation. He recovered well with the treatment and the pulmonary infiltrates in the chest X-ray resolved within 5 days after the onset of respiratory failure. He was eventually discharged without major sequelae.

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“…The median APACHE IV score in our study was higher than that of GWY Ng et al (105 vs. 76.9) indicating our patients had more severe diseases. 26 Survivors had significantly longer hospital LOS (44.5 days vs. 17.3 days, p < 0.001). The median hospital LOS and ICU LOS in the current study were longer than those described in an international study of ARDS patients in general.…”

Section: Hospital Mortalitymentioning

confidence: 92%

An External Validation of Scoring Systems in Mortality Prediction in Veno-Venous Extracorporeal Membrane Oxygenation

et al. 2021

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Three-year experience of using venovenous extracorporeal membrane oxygenation for patients with severe respiratory failure

Cited by 6 publications

References 9 publications

Defining and understanding the “extra‐corporeal membrane oxygenation gap” in the veno‐venous configuration: Timing and causes of death

Defining and understanding the “extra‐corporeal membrane oxygenation gap” in the veno‐venous configuration: Timing and causes of death

A Case of Severe Varicella Pneumonia Requiring Extracorporeal Membrane Oxygenation

An External Validation of Scoring Systems in Mortality Prediction in Veno-Venous Extracorporeal Membrane Oxygenation

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