2007
DOI: 10.1128/jcm.00170-07
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Three-Year Longitudinal Study of Genotypes of Mycobacterium tuberculosis Isolates in Tuscany, Italy

Abstract: The genetic diversity of 829 strains of Mycobacterium tuberculosis isolated during a 3-year period in Tuscany, Italy, a country with a low prevalence of tuberculosis, from 480 Italian-born and 349 foreign-born patients was determined by spoligotyping. The predominant spoligotype families were T (30.2% of isolates), Haarlem (19.9%), and the Latino-American and Mediterranean family (LAM) (11.2%); the remaining isolates were distributed among the Beijing (6.5%), S (4.2%), East Africa-India (EAI) (3.0%), Bovis (2.… Show more

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Cited by 29 publications
(23 citation statements)
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“…Although spoligotyping per se is not an appropriate method for assessing the burden of recently transmitted TB (it may overestimate the proportion of clustered cases [22][23][24]), it serves as an efficient preliminary procedure in determining the genetic relatedness of M. tuberculosis isolates (8,9,15,26,30,31,34). Furthermore, the interpretation of the clustering results in the context of recent transmission is fraught with several ambiguities.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Although spoligotyping per se is not an appropriate method for assessing the burden of recently transmitted TB (it may overestimate the proportion of clustered cases [22][23][24]), it serves as an efficient preliminary procedure in determining the genetic relatedness of M. tuberculosis isolates (8,9,15,26,30,31,34). Furthermore, the interpretation of the clustering results in the context of recent transmission is fraught with several ambiguities.…”
Section: Resultsmentioning
confidence: 99%
“…Studying genetic relationships among M. tuberculosis strains has provided important insights into the spread and transmission of TB (8,15,26,30,31,34). Spoligotyping targeting the polymorphism of the chromosomal direct-repeat locus is one of the most extensively used techniques for genotypic differentiation between M. tuberculosis strains (27).…”
mentioning
confidence: 99%
“…According to a World Health Organization (WHO) report, TB causes nearly 50 to 100 million infections, 9.4 million new cases and 1.3 million deaths every year [2,3], and the situation in developing countries is especially serious. China has the second-highest TB-burden globally, behind only India [3], and data from the 5 th national TB epidemiological survey conducted in 2010 indicate that TB has an estimated incidence of 459 cases per 100,000 [95% confidence interval (CI): 433–484] in China, with 4.99 million prevalent TB cases (95% CI: 4.71-5.27), including 1.19 million pulmonary, bacteriologically confirmed cases (95% CI: 1.03-1.35) [4].…”
Section: Introductionmentioning
confidence: 99%
“…In fact, the increased infectivity of strains that are found at extrapulmonary locations has been demonstrated by the studies of Garcia de Viedma et al [10]. In the present study, the association of extrapulmonary TB with the M. tuberculosis genotypic lineages defined in the SpolDB4 database [11] using the spacer oligonucleotide typing assay (spoligotyping) [12] was determined in a population-based, 4-year survey performed in Tuscany, Italy, a region with a low prevalence of TB, where different autochthonous and imported M. tuberculosis genotypic lineages coexist, owing to a recent increase in immigration from high-prevalence countries [13].…”
Section: Introductionmentioning
confidence: 99%