Three years survival rate of epithelial ovarian cancer patients in Dr. Kariadi Hospital, Semarang, Central Java

Abstract

Tujuan: mengetahui hubungan antara faktor-faktor prognostik kanker ovarium dengan kesintasan tiga tahun pasien kanker ovarium epitelial. Bahan dan Metode: Penelitian kohort retrospektif pada 90 pasien (selama tahun 2012) di RSUP Dr. Kariadi. Kaplan Meier, Log rank, dan Cox regresi digunakan untuk menganalisa kesintasan dan faktor prognostik yang berhubungan dengan penyakit ini. Hasil: Kesintasan 3 tahun pasien kanker ovarium epitelial secara keseluruhan adalah sebesar 58,5% (Kaplan Meier). Kesintasan 3 tahun pasien kanker ovarium epitelial adalah sebesar 89,3%, 44,4%, dan 35,1%, pada pasien dengan stadium I, stadium II, dan stadium III secara berurutan, dan tidak ada pasien yang bertahan hidup hingga 3 tahun pada stadium IV. Faktor prognostik yanng berhubungan dengan kesintasan 3 tahun pasien kanker ovarium epitelial yaitu stadium, asites, residu tumor, dan jenis histopatologi {p<0,001; p=0,001; p=0,004; p=0,041, secara berurutan (uji Log rank)}, sedangkan usia dan ukuran tumor tidak berhubungan. Setelah dilakukan analisis multivariat (Cox regresi), hanya stadium yang berhubungan dengan kesintasan 3 tahun pasien kanker ovarium epitelial. Simpulan: Ada hubungan antara stadium, asites, residu tumor, jenis histopatolog dengan kesintasan 3 tahun penderita kanker ovarium epitelial. Stadium merupakan faktor prognostik yang paling mempengaruhi kesintasan 3 tahun penderita kanker ovarium epitelial pada penelitian ini.Kata kunci: kanker ovarium epitelial, faktor prognostik, kesintasan 3 tahun Objectives: to determine the association between prognostic factors of ovarian cancer with a 3-years survival rate of epithelial ovarian cancer patients. Material and Method:Retrospective cohort study was conducted in 90 patients (during 2012) at Dr.Kariadi General Hospital. Kaplan meier, Log rank and Cox regression were used to analyse survival rate and prognostic factors that influence the disease. Result: Overall 3-years survival rate of epithelial ovarian cancer patients were 58.5% (Kaplan meier). Three-years survival rates were 89.3%, 44,4%, and 35.1% for patients in stage I, stage II, and stage III, respectively, and no patient survive up to 3 years in stage IV. Prognostic factors that associated with 3-years survival rate were stage of the disease, ascites, residual tumor, and type of histopathology {p<0,001; p=0,001; p=0,004; p=0,041, respectively (Log rank test)}, whereas age and size of tumor were not associated. After using multivariate analysis (Cox regression) only stage of the disease was associated with 3-years survival rate of epithelial ovarian cancer patients. Conclusion: There were an association between stage of the disease, ascites, residual tumor, type of histopathology, and 3-years survival rate of epithelial ovarian cancer patients. Stage of the disease was a prognostic factor that most influence 3-years survival rate of epithelial ovarian cancer patiens in this study.

Correlation between clinicopathological factors and clinical outcomes of recurrent epithelial ovarian cancer at a tertiary hospital in Surabaya, Indonesia

“…15 The presence of spheroid cells (mesothelial and tumor) in ascites also causes chemoresistance thereby resulting in shorter DFS and OS. [16][17][18][19][20] Tumor conditions with ascites have worse prognoses because they have a much greater potential for metastases. 21 We found that mucinous and clear cell histopathology had a worse survival outcome than those of other histologic types.…”

Correlation between CD133 and EGFR Expression with Grading of Ovarian Carcinoma

“…18 Karsinoma ovarium merupakan kasus yang sulit untuk dilakukan deteksi lebih awal, sehingga angka kematiannya selalu meningkat, sehingga dikenal dengan istilah "the lady silent killer". 19 Kejadian karsinoma ini meningkat karena perubahan gaya hidup terutama di daerah negara berkembang misalnya, nutrisi, merokok, masalah reproduksi. 20 Penelitian ini menunjukkan adanya perbedaan ekspresi CD133 yang bermakna antara karsinoma ovarium derajat rendah dan derajat tinggi (α=0,05; p=0,0001; p<α).…”