Threshold dose of cytogenetic toxicity of lindane, malathion and metacid in allium cepa root-tip cells.

Kumar, D. Srinivas; Sinha, S. P.

doi:10.1508/cytologia.54.547

Cited by 7 publications

(4 citation statements)

References 8 publications

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“…Production of electrophilic ions and reactive radicals during the metabolism of wastes might be interacting with the nucleophilic sites in DNA leading to breaks and other related damages in latter (Klopman et al 1985). While Chaurasia and Sinha (1987, 1988, 1990 were studying on genotoxicity induced by fertilizer; Kumar and Sinha (1989) on dosed-dependent genotoxic effects of synthetic pesticides, they also observed that individual type of damages were more frequent than the gross type at the various doses. Bose and Sinha (1994), Dharmashila and Sinha (1994) and Awasthy et al (2000) could find that the biomutagens induced more gross type of abnormalities than individual types, since mutagens induce mitotic-poisoning of the cells leading to gross type of abnormalities.…”

Section: Resultsmentioning

confidence: 99%

Genotoxic Effect of Silk Dyeing Wastes in Bone Marrow Cells of Mice, Mus musculus

2005

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Summary Untreated wastes (0.125, 0.25, 0.50 & 1.0%) from silk industries induced both gross and individual types of chromosome abnormalities in bone marrow cells of mice. The frequency of the abnormalities increased with the increase of doses. Polyploidy and aneuploidy were found to be common among the gross, while chromatid breaks, gaps acentric fragments were most common among the individual type. The waste interferred the internal milieu of cells leading to grosstype of demages, while certain ions and reactive radicals formed during their metabolism induced the breakage in the chromosomes.

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Section: Resultsmentioning

confidence: 99%

Genotoxic Effect of Silk Dyeing Wastes in Bone Marrow Cells of Mice, Mus musculus

2005

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“…Kumar et al (1995): MT ranging from 0 to 100 mg L -1 ; 8. Kumar and Sinha (1989): concentrations of 0.1;0.5;1.0;5.0;10.0; 25.0; 100.0; 250.0; 500.0 ppm (corresponding to 0.0001mg mL -1 to 0.5 mg mL -1 ).…”

Section: Discussionmentioning

confidence: 99%

Integrative analysis in toxicological assessment of the insecticide Malathion in Allium cepa L. system

et al. 2023

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For many centuries human populations have been suffering and trying to fight with disease-bearing mosquitoes. Emerging and reemerging diseases such as Dengue, Zika, and Chikungunya affect billions of people around the world and recently has been appealing to control with chemical pesticides. Malathion (MT) is one of the main pesticides used against mosquitoes, the vectors of these diseases. This study aimed to assess cytotoxicity and mutagenicity of the malathion for the bioindicator Allium cepa L. using a multivariate and integrative approach. Moreover, an appendix table was compiled with all available literature of insecticides assessed by the Allium cepa system to support our discussion. Exposures during 48h to 0.5 mg mL-1 and 1.0 mg mL-1 MT were compared to the negative control (distilled water) and positive control (MMS solution at 10 mg L-1). The presence of chromosomal aberrations, micronuclei frequency, and mitotic index abnormalities was evaluated. Anaphase bridges were the alterations with higher incidence and presented a significantly elevated rate in the concentration of 0.5 mg mL-1, including when compared to the positive control. The integrative discriminant analysis summarizes that MT in assessed concentrations presented effects like the positive control, corroborating its potential of toxicity to DNA. Therefore, it is concluded that MT in its pure composition and in realistic concentrations used, has genotoxic potential in the biological assessment of A. cepa cells. The multivariate integrative analysis was fundamental to show a whole response of all data, providing a global view of the effect of MT on DNA.

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“…Bridges and laggards are observed as a result of retardness of chromosomal movements due to stickiness of chromosomal ends (Darlington and Cour, 1976). The error of spindle organization leads to multipolar spindle formation probably due to formation of more than two poles (Kumar and Sinha, 1989;EI Khodary et al, 1990). The telophase abnormality were mostly binucleated cells which is due to inhibition of cell cycle and also due to failure in cell plate formation, disorder occurred in phragmoplast formation (Olah and Hanzely, 1973).…”

Section: Discussionmentioning

confidence: 99%

Cytological Effects of Leaf Extract of Artemisia vulgaris L. on Meristematic Cells of Allium cepa L.

Rai¹,

Paudel²,

Shakya³

2013

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Artemisia vulgaris L., a perennial aromatic shrub with bitter taste, is considered as a medicinal plant and water extract of it consists of active components like psilostachyin A, psilostachy C, Exiguaflavanone A, Maackiain, fernenol with both anti-bacterial and medicinal value. It has been used to perserve crops and stored grains both in liquid and powder by farmers. The cytological effect was observed in 5, 7.5, 10 and 20% concentrations of Leaf Extract of Artemisia vulgaris (LEA) on Allium cepa L. in five different time durations. The present study showed the correlation between concentration of LEA and duration of treatment in controlled state. Higher concentrations of LEA as well as longer duration of treatment generate the inhibitory effect on the division of cells. Lower concentration of LEA showed less effect on Mitotic Index value (MI) in comparison with control value, which is attributed to delay in metabolic activities. It also showed the change in phase indices and induced chromosomal abnormalities among the phases.

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Threshold dose of cytogenetic toxicity of lindane, malathion and metacid in allium cepa root-tip cells.

Cited by 7 publications

References 8 publications

Genotoxic Effect of Silk Dyeing Wastes in Bone Marrow Cells of Mice, Mus musculus

Genotoxic Effect of Silk Dyeing Wastes in Bone Marrow Cells of Mice, Mus musculus

Integrative analysis in toxicological assessment of the insecticide Malathion in Allium cepa L. system

Cytological Effects of Leaf Extract of Artemisia vulgaris L. on Meristematic Cells of Allium cepa L.

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