Thrombin Generation in Severely Obese Children

Cimenti, Christina; Mangge, Harald; Leschnik, B.; Haidl, Harald; Hiden, M.; Rosenkranz, A.; Zach, D.; Pilz, Stefan; Muntean, W.

doi:10.1007/978-3-540-73535-9_11

Cited by 8 publications

(10 citation statements)

References 7 publications

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“…Our results are in agreement with previous papers which showed that obesity is often associated with alterations in the coagulation factor levels predisposing to hypercoagulability (1,43,44). In particular, PMP levels have been reported to be significantly elevated in obese non-diabetic subjects in comparison to non-obese subjects, and the values correlated with BMI, waist circumference, fat tissue mass; significant reductions in PMP levels were observed after weight loss (25).…”

Section: Discussionsupporting

confidence: 93%

Hypercoagulability in overweight and obese subjects who are asymptomatic for thrombotic events

Campello¹,

Zabeo²,

Radu³

et al. 2015

Thromb Haemost

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The role of circulating microparticles (MP) of different origin and tissue factor (TF)-bearing in overweight and obese patients with and without metabolic syndrome is still a matter of debate. In a case-control study, the presence of hypercoagulability was evaluated in overweight and obese patients by measuring MP, thrombin generation (TG) and FVIIa-AT complexes. Twenty overweight patients (body mass index [BMI] range 25-29.9 kg/m²), 20 with I degree (30-34.9 kg/m²), 20 with II degree (35-39.9 kg/m²) and 20 with III degree obesity (≥ 40 kg/m²) were enrolled and compared to 40 age and gender-matched normal weight individuals. A significant increase in median levels of all MP subtypes was observed in the three degrees of obese patients compared to controls. Overweight patients had higher levels of annexin V-MP (AMP), endothelial-derived, leukocyte-derived and TF-bearing MP than controls. Obese patients had a significantly shorter median lag time (p< 0.05), higher median peak thrombin (p< 0.01) and increased median endogenous thrombin potential [ETP] (p< 0.001) compared to controls. Overweight subjects had significantly increased ETP compared to controls (p< 0.05). Both AMP levels and ETP were found to positively correlate with BMI, waist circumference, and inflammatory parameters. No significant increase in FVIIa-AT complex was seen in cases compared to controls. We conclude that obesity is associated with overproduction of procoagulant MP and increase TG. Interestingly, hypercoagulability is found in overweight patients free of metabolic syndrome and increases with the severity of obesity. Assessment of MP and TG may be helpful in the early characterisation of the prothrombotic state in obese patients.

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Section: Discussionsupporting

confidence: 93%

Hypercoagulability in overweight and obese subjects who are asymptomatic for thrombotic events

Campello¹,

Zabeo²,

Radu³

et al. 2015

Thromb Haemost

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“…Indeed, in a previous study, we could demonstrate a high thrombin generation potential in patients with morbid obesity, which significantly decreased after weight loss [10]. An association between obesity and thrombin generation was also reported in other studies [19,20]. However, in our current study, there was no difference of the BMI between the various subgroups that were analysed.…”

Section: Discussionsupporting

confidence: 76%

Thrombin generation in type 2 diabetes with albuminuria and macrovascular disease

Hoellerl

et al. 2011

Eur J Clin Investigation

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“…In addition, in a recent study, we demonstrated a steady increase of ETP with age that might help to explain the increased incidence of thrombembolic disease observed with advanced age 16 . Investigating alterations of hemostasis in obesity we have shown that overweight children generate significantly higher amounts of thrombin after a significantly prolonged lag time in comparison to age‐matched, normal‐weight, healthy controls 17 …”

Section: Discussionmentioning

confidence: 67%