Thrombin, kallikrein and complement C5b-9 adsorption on hydrophilic and hydrophobic titanium and glass after short time exposure to whole blood

Yahyapour, Noushin; Eriksson, Cecilia; Malmberg, Per; Nygren, Håkan

doi:10.1016/j.biomaterials.2003.10.011

Cited by 29 publications

(27 citation statements)

References 30 publications

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“…16 One can speculate that the hydrophilic surface adsorbs proteins such as fibrinogen in a misfolded way, which in turn promotes both contact activation and platelet binding with subsequent activation. 23 On the other hand, in a recent study by Sperling and colleagues reduced platelet binding and intermediate thrombin formation on a hydrophilic surface was described. 19 In addition, it is well established that fibrinogen is important for the binding of platelets by GPIIb/IIIa to the material surface.…”

Section: Discussionmentioning

confidence: 98%

A Hydrophilic Dental Implant Surface Exhibit Thrombogenic Properties In Vitro

Hong

Kurt

Thor

2011

Clin Implant Dent Rel Res

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Section: Discussionmentioning

confidence: 98%

A Hydrophilic Dental Implant Surface Exhibit Thrombogenic Properties In Vitro

Hong

Kurt

Thor

2011

Clin Implant Dent Rel Res

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“…Previous studies demonstrated that both SLA and SLActive titanium surfaces are able to significantly enhance bone formation in comparison to smooth surfaces, with new bone formation already detectable at 1 week of healing in human biopsies . In vitro studies suggested that the advantage of hydrophilic surfaces during the initial healing stages is that they promote better interactions with osteogenic cells, biological fluids and tissues and they increase the expression of osteogenic markers . Robust changes in gene expression have been documented during early stages of osseointegration of SLA vs SLActive implants, with increased expression of angiogenesis‐ and osteogenesis‐related genes at 7 and 14 days in SLActive surfaces .…”

Section: Discussionmentioning

confidence: 99%

“…Chemical modification of the SLA implant surfaces to increase their surface free energy and wettability (SLActive) has been introduced to further optimize their properties. It has been shown that during early healing stages, a hydrophilic surface can further promote interactions with osteogenic cells, biological fluids and tissues, thus enhancing the process of osteogenesis . There is also preclinical evidence that during the early stages of osseointegration, SLActive surfaces accelerate osteogenesis, increase bone‐to‐implant contact and lead to a higher removal torque in comparison to SLA surfaces.…”

Section: Introductionmentioning

confidence: 99%

Protein expression during early stages of bone regeneration under hydrophobic and hydrophilic titanium domes. A pilot study

Calciolari

Mardas

Dereka

et al. 2017

J of Periodontal Research

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This is the first study describing the proteome expressed during early healing stages of guided bone regeneration and osseointegration. A combination of enhanced early osteogenic response and reduced inflammatory response were suggested for the hydrophilic group. Future studies are needed to corroborate these findings and explore the molecular effects of different titanium surfaces on the cascade of events taking place during bone formation.

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“…20 Hydrophobicity of a surface can lead to reduced protein adsorption and insufficient wettability may influence initial conditioning of the surface by blood components and affect subsequent cellular reactions. 25 For improving surface energy, a new production method was developed to produce hydroxylated/hydrated Ti surfaces with identical microstructure to SLA substrates, but with immediate wettability and extreme hydrophilic character ( fig. 1).…”

Section: Surface Propertiesmentioning

confidence: 99%

Improved osseointegration of a novel, hydrophilic Ti surface – a review

Molenberg¹,

Schwarz²,

Herten³

et al. 2009

Materialwissenschaft Werkst

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The high surface energy of sandblasted and acid etched (SLA) titanium surfaces can be retained by keeping them submersed in an isotonic NaCl solution at pH 4 to 6 under a nitrogen atmosphere immediately after the acid-etching process, thus reducing the adsorption of potential contaminants from the atmosphere. The novel implant surface thus produced shows a strongly increased hydrophilicity, compared to the conventional SLA surface, and is named SLActive.Several animal studies have indicated a faster osseointegration of the SLActive surface, compared to the SLA surface, and improved regeneration in bone defects next to implants. Histological and immunohistochemical studies have shown improved wound healing at the SLActive surface only a few days after implantation and a pilot clinical study has shown the break point from decreasing stability to increasing stability occurring after 2 weeks for SLActive implants, compared to 4 weeks for SLA implants.Key words: surface energy, surface chemistry, hydrophilicity, titanium implant surfaces, biomechanical testing, histology, immunohistochemistry, implant stability Die hohe Oberflächenenergie von sandgestrahlte und Säure-geätzte (SLA) Titan-Oberflächen kann erhalten werden, indem sie sofort nach dem Ä tzprozess in isotonischer NaCl-Lösung bei pH 4 bis 6 und unter Stickstoff-Atmosphäre gelagert werden. Die Adsorption potentieller Kontaminanten aus der Atmosphäre wird so verringert und die so hergestellte Implantatoberfläche ("SLActive") zeigt eine stark zugenommene Hydrophilizität, verglichen mit der konventionellen SLA-Oberfläche.Verschiedene Tierstudien haben eine schnellere Osseointegration der SLActive-Oberfläche gezeigt, verglichen mit der SLA-Oberflä-che, sowie verbesserte Regeneration in Knochendefekten neben den Implantaten. Histologische and immunohistochemische Studien haben bereits wenige Tage nach der Implantation eine verbesserte Wundheilung an der SLActive-Oberfläche gezeigt und in einer pilot-klinischen Studie wurde eine Verschiebung des Knickpunktes von abnehmender zu zunehmender Stabilität von 4 Wochen für SLA-Implantate zu 2 Wochen für SLActive-Implantate gefunden.

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Thrombin, kallikrein and complement C5b-9 adsorption on hydrophilic and hydrophobic titanium and glass after short time exposure to whole blood

Cited by 29 publications

References 30 publications

A Hydrophilic Dental Implant Surface Exhibit Thrombogenic Properties In Vitro

A Hydrophilic Dental Implant Surface Exhibit Thrombogenic Properties In Vitro

Protein expression during early stages of bone regeneration under hydrophobic and hydrophilic titanium domes. A pilot study

Improved osseointegration of a novel, hydrophilic Ti surface – a review

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