Thrombocytopenia Associated With the Administration of Diethylstilbestrol in Man

Cooper, Bernard A.; Bigelow, Frederick S.

doi:10.7326/0003-4819-52-4-907

Cited by 21 publications

(3 citation statements)

References 5 publications

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“…Hormonal suppression of megakaryocyte function is associated with hyperoestrogenic states. Oestrogen has been shown to impair haematopoiesis in animals [ 23 ], to cause thrombocytopenia in humans [ 24 ], and to regulate Fc receptor expression on macrophages [ 25 ]. Administration of diethylstilbestrol has been reported to lead to amegakaryocytic thrombocytopaenia [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Oestrogen has been shown to impair haematopoiesis in animals [ 23 ], to cause thrombocytopenia in humans [ 24 ], and to regulate Fc receptor expression on macrophages [ 25 ]. Administration of diethylstilbestrol has been reported to lead to amegakaryocytic thrombocytopaenia [ 24 ]. The exact mechanism of oestrogen-induced megakaryocyte suppression remains uncertain but is thought to be due to modulation of Fc receptor expression on macrophages and facilitating reticuloendothelial phagocytosis [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…It works by negative feedback on the hypothalamus leading to a hypooestrogenic and hypoprolactinaemic state. As previously mentioned, hyperoestrogenic therapies have previously been associated with impaired megakaryocyte maturation [ 23 , 24 ]. Exactly how danazol improves amegakaryocytic thrombocytopenia is unknown but may relate either to Fc receptor modulation on macrophages or to its effects on oestrogen [ 23 – 25 ].…”

Section: Discussionmentioning

confidence: 99%

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Danazol: An Effective Option in Acquired Amegakaryocytic Thrombocytopaenic Purpura

Mulroy

Gleeson

Chiruka

2015

Case Reports in Hematology

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Acquired amegakaryocytic thrombocytopaenic purpura (AATP) is a rare haematological condition characterised by isolated thrombocytopaenia with normal other cell lines. It is often initially misdiagnosed as immune thrombocytopaenic purpura but has characteristic bone marrow findings of reduced megakaryocyte numbers. The optimal treatment of AATP is not clearly defined but revolves around immunosuppressive therapies. We report a case of successful treatment of AATP with danazol, an antioestrogenic medication. We also review the aetiologies and pathogenesis of the disorder and suggest that danazol should be considered as an effective alternative to potent immunosuppression in AATP.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Danazol: An Effective Option in Acquired Amegakaryocytic Thrombocytopaenic Purpura

Mulroy

Gleeson

Chiruka

2015

Case Reports in Hematology

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Myelodysplastic syndromes presenting in pregnancy: A report of five cases and the clinical outcome

Siddiqui

Elfenbein

Noyes

et al. 1990

Cancer

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Five female patients, ranging in age between 22 and 36 years, presented with myelodysplastic syndromes during pregnancy between June 1982 and March 1987. Three of these five cases evolved into acute leukemia. A bone marrow transplant was attempted in the fourth. It is suggested that the association of myelodysplastic syndromes during pregnancy is more than coincidental and that acute leukemia evolves in a majority of these cases. Furthermore, refractory macrocytic anemias in pregnancy need to be carefully evaluated for a primary myelodysplastic state. Cancer 66:377-381,1990, HE MYELODYSPLASTIC SYNDROMES (MDS) are aT group of hematologic disorders that manifest dysplastic hematopoiesis and usually a hypercellular bone marrow. Ineffective hematopoiesis leads to hematologic failure in these syndromes. In 20% to 70% of these cases acute nonlymphocytic leukemia eventually evolve.'-3 Although MDS largely affects older individuals (70 years of age or older), no age group is spared, and in fact, 10% of the patients are younger than 40 years of age.4 Myelodysplastic syndromes may be primary when it is of unknown cause, and secondary when preceded by some known inciting event, usually exposure to chemotherapy and/or radiotherapy.' In 1982, the French-AmericanBritish (FAB) classification was introduced which has resulted in the creation of five subsets of MDS. This classification is now widely used resulting in better standardization when evaluating MDS and its evolving concepts.6At the University of Florida hospitals, five patients have been seen between 1982 and 1987 whose anemia or MDS presented initially during pregnancy. A review of the literature has revealed no information about such occurrences and their clinical behavior. The aggressive clinical

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Acquired amegakaryocytic thrombocytopenic purpura

et al. 2006

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Thrombocytopenia Associated With the Administration of Diethylstilbestrol in Man

Cited by 21 publications

References 5 publications

Danazol: An Effective Option in Acquired Amegakaryocytic Thrombocytopaenic Purpura

Danazol: An Effective Option in Acquired Amegakaryocytic Thrombocytopaenic Purpura

Myelodysplastic syndromes presenting in pregnancy: A report of five cases and the clinical outcome

Acquired amegakaryocytic thrombocytopenic purpura

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