Thrombocytopenia in Patients with Chronic Liver Disease: What’s in a Name?

Giannini, Edoardo G.

doi:10.1007/s10620-012-2450-7

Cited by 9 publications

(6 citation statements)

References 17 publications

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“…In agreement with a previously published study [32] , which confirmed that decreased platelet count was a good indicator of the severity of chronic liver diseases, we found that serum albumin levels were significantly lower (P = 0.026) and INR values were significantly higher (P <0.001) in thrombocytopenic than non-thrombocytopenic patients. Furthermore, platelet count showed significant positive correlation with serum albumin levels (r = 0.579; P < 0.001) and negative correlation with INR values (r = -0.694; P < 0.001).…”

Section: Discussionsupporting

confidence: 93%

Reticulated Platelets in Egyptian Patients with Chronic Hepatitis C Infection

Boshnak¹

2017

jmscr

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Section: Discussionsupporting

confidence: 93%

Reticulated Platelets in Egyptian Patients with Chronic Hepatitis C Infection

Boshnak¹

2017

jmscr

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“…Through a meta-analysis, Zhang et al showed that thrombocytopenia in HCC patients was associated with poor OS (HR: 1.47, 95% CI 1.21–1.78) and poor RFS (HR: 1.41, 95% CI: 1.22–1.62) in HCC patients after hepatic resection [35]. Platelet count has been used to assess the severity of chronic liver disease and features of portal hypertension [36]. In the present study, low SII was associated with high APRI and high INR, which are related to significant fibrosis and poor liver function.…”

Section: Discussionmentioning

confidence: 99%

Predictive Effects of Inflammatory Scores in Patients with BCLC 0-A Hepatocellular Carcinoma after Hepatectomy

Huang

Wang

Lin

et al. 2019

JCM

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Background: Inflammatory markers are regarded as prognostic factors of the outcomes of hepatocellular carcinoma (HCC). Examples include the neutrophil-to-lymphocyte ratio (NLR); platelet to lymphocyte ratio (PLR); the albumin and lymphocyte counts used in the prognostic nutritional index (PNI); and the neutrophil, lymphocyte, and platelet counts used in the systemic immune-inflammation index (SII). This study evaluates the effects of PNI, NLR, PLR, and SII to predict recurrence and survival in patients with Barcelona Clinic Liver Cancer (BCLC) stages 0-A of HCC after hepatectomy. Methods: This retrospective study was conducted at Kaohsiung Chung-Gung Memorial Hospital, Taiwan. The study enrolled 891 patients (77.9% males; mean age 58.53 ± 11.60 years) with BCLC stage 0/A HCC undergoing hepatectomy between 2001 and 2016. PNI, NLR, PLR and SII were measured before hepatectomy. Results: High NLR (>1.8) was adversely associated with overall survival (p = 0.032). Low PNI (≤45) was adversely associated with overall survival and disease-free survival (p < 0.001). Low SII (≤45) also had an adverse association with overall survival (p = 0.008) and disease-free survival (p < 0.001). Diabetes mellitus, cirrhosis, microvascular invasion, low PNI (≤45), and low SII (≤160) were independently associated with poor overall survival in a multivariate analysis. HCV infection, diabetes mellitus, cirrhosis, microvascular invasion, low PNI, and low SII were independent prognostic factors of recurrent HCC. The combined use of PNI and SII provided improved prognostic information. Conclusions: Low PNI and low SII are significantly poor prognostic factors for overall survival and recurrence in patients with BCLC 0-A hepatocellular carcinoma after hepatectomy.

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“…This evidence is supported by the lack of correlation between HVPG value and platelet count, and by the absence of influence of β‐blockers administration on indirect indexes of portal hypertension . Thus, thrombocytopaenia, which may be influenced by various factors not necessarily linked with portal hypertension, should be considered a poor surrogate marker for HVPG in these patients . Indeed, the study which assessed both HVPG and indirect indexes of portal hypertension in 40 patients who underwent HR for HCC showed that criteria used to indirectly assess clinically significant portal hypertension overestimate the proportion of patients who actually had portal hypertension: in fact, while 26 individuals were classified as portal hypertensive cases using indirect criteria, only 18 showed an HVPG ≥10 mmHg .…”

Section: Discussionmentioning

confidence: 99%