Thrombocytosis: a retrospective study of 165 dogs

Neel, Jennifer A.; Snyder, Laura A.; Grindem, Carol B.

doi:10.1111/j.1939-165x.2012.00416.x

Cited by 43 publications

(68 citation statements)

References 25 publications

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“…This incidence is similar to a previous report that investigated thrombocytosis in both dogs and cats . Lower incidences are reported previously in a canine (4.5%) and a feline (4.6%) restrospective study . This difference can likely be attributed to the platelet count cutoff used to define a thrombocytosis.…”

Section: Discussionsupporting

confidence: 90%

“…Secondary thrombocytosis occurs due to an underlying process such as neoplasia, inflammation, trauma, or iron deficiency . Neoplasia is the most common cause in several study populations of dogs . Thrombocytosis is commonly reported in dogs with hyperadrenocorticism or which have concurrent administration of glucocorticoid, although the mechanism is not well understood .…”

mentioning

confidence: 99%

“…Extreme thrombocytosis is defined as a platelet count greater than 1,000 × 10 3 /μL. In a previous study of dogs, extreme thrombocytosis was more commonly associated with a diagnosis of neoplasia, but there was no association with thromboembolic risk . Case reports of thromboembolic complications due to thrombocytosis in dogs are limited, and there is a dearth of research investigating the use of thrombocytosis as a prognostic factor in veterinary medicine …”

mentioning

confidence: 99%

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Thrombocytosis in 715 Dogs (2011–2015)

Woolcock

Keenan

Cheung

et al. 2017

Veterinary Internal Medicne

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BackgroundThrombocytosis is a hematologic abnormality in dogs that has been associated with various neoplastic, metabolic, and inflammatory conditions.ObjectiveTo classify thrombocytosis in dogs based on severity and evaluate whether there are associations between severity and underlying disease processes.AnimalsSeven hundred and fifteen dogs with thrombocytosis and 1,430 dogs with normal numbers of platelets.MethodsRetrospective study. Medical records of dogs with increased (>500 × 103/μL; thrombocytosis group) and normal (300–500 × 103/μL; control group) platelet counts between 2011 and 2015 were reviewed. Dogs were characterized by severity of platelet increase and diagnosis. Diagnostic categories included neoplasia, endocrine disease, inflammatory disease, or miscellaneous.ResultsA total of 1,254 complete blood counts with thrombocytosis from 715 dogs were included in the study. Median platelet count in this population was 582 × 103/μL (500–1,810 × 103/μL). No correlation between severity of thrombocytosis and diagnosis was identified. Causes of secondary thrombocytosis included neoplasia (55.7%), endocrine disease (12.0%), and inflammatory disease (46.6%). Immune‐mediated disease was common (22.2%), associated with frequent glucocorticoid administration, and had a significantly higher median platelet count (636 × 103/μL [500–1,262 × 103/μL] versus 565 × 103/μL [500–1,810 × 103/μL]) when compared to the other inflammatory processes (P < 0.001). The diagnoses in the thrombocytosis dogs differed significantly from the control population (P < 0.001).Conclusions and Clinical ImportanceThrombocytosis is commonly associated with carcinoma and immune‐mediated disease in dogs.

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Section: Discussionsupporting

confidence: 90%

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confidence: 99%

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confidence: 99%

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Thrombocytosis in 715 Dogs (2011–2015)

Woolcock

Keenan

Cheung

et al. 2017

Veterinary Internal Medicne

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“…As we did not determine ALP isotypes, a contribution of increased bone ALP isotype originating from neoplastic osteoblasts cannot be ruled out in this dog. Likewise, the borderline thrombocytosis may have been either glucocorticoid‐mediated due to hyperadrenocorticism, or paraneoplastic due to production of granulocyte–macrophage colony‐stimulating factor, interleukin 6, or thrombopoietin by tumor tissue …”

Section: Discussionmentioning

confidence: 69%

Paraganglioma, pituitary adenoma, and osteosarcoma in a dog

Robat

Houseright

Murphey³

et al. 2016

Veterinary Clinical Pathol

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An 11-year-old neutered male Alaskan Malamute mixed-breed dog was presented with a complaint of polyuria/polydipsia (PU/PD), weight loss, tachypnea, regurgitation, and a previous history of nontreated osteosarcoma of the right distal radius, diagnosed 21 months prior. On physical examination, an abdominal mass was palpated. The abdominal mass was aspirated and cytologically diagnosed as a neuroendocrine tumor, suspected to be a pheochromocytoma. Laboratory examination revealed a mild anemia and thrombocytopenia, markedly elevated ATP and ALP activities, and moderate hypercalcemia. A low-dose dexamethasone suppression test and endogenous adrenocorticotropic hormone (ACTH) concentration were compatible with pituitary hyperadrenocorticism. On urinalysis, proteinuria was noted as well as a high urine metanephrine/creatinine ratio, consistent with a diagnosis of pheochromocytoma. The dog was treated with supportive care and euthanized 6 months later due to decreasing quality of life. On necropsy, an extra-adrenal pheochromocytoma (paraganglioma) was diagnosed in the caudal abdomen, and a pituitary adenoma and an osteosarcoma of the right distal radius were confirmed.

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“…Anaemia was considered regenerative when the reticulocyte concentration determined by the ADVIA 120 was $82 Â 10 9 /l (Moritz, 2011). In addition, the dogs were also classified by aetiopathology of disease (Table 1) as described by Neel et al (2012). Exclusion criteria included repeated samples from the same animal or samples with haemolysis, lipaemia or icterus.…”

Section: Animals and Inclusion Criteriamentioning

confidence: 99%