Thrombocytosis and giant cell arteritis

Price, N.; Clearkin, L G

doi:10.1016/s0140-6736(94)92665-4

Cited by 20 publications

(10 citation statements)

References 2 publications

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“…In 1963 Olhagen (4) first reported thro m b o c y t o s i s in 7 of his 12 GCA patients. Since then several reports of thrombocytosis in GCA have appeared in the l i t e r a t u re (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21), and Table I summarizes the major reports in the English language literature. These stud-ies have suggested a role for estimation of platelet count in diagnosis and management of GCA because a decrease in platelet count with steroid therapy has also been reported.…”

Section: Introductionmentioning

confidence: 99%

Role of Thrombocytosis in Diagnosis of Giant Cell Arteritis and Differentiation of arteritic from Non-Arteritic Anterior Ischemic Optic Neuropathy

Costello

Zimmerman

Podhajsky

et al. 2004

European Journal of Ophthalmology

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Patients with GCA had significantly (p <0.0001) higher values of platelet count, ESR, CRP and WBC but lower values for hemoglobin and hematocrit compared to the NA-AION group. Predictive ability of an elevated platelet count did not surpass elevated ESR or CRP as a diagnostic marker for GCA. Thrombocytosis may complement ESR. Hemoglobin, hematocrit and WBC were much less predictive of GCA. Elevated CRP had a greater predictive ability for GCA compared to ESR or the other hematologic parameters; thrombocytosis in combination with CRP did not yield an improvement in prediction of GCA.

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Section: Introductionmentioning

confidence: 99%

Role of Thrombocytosis in Diagnosis of Giant Cell Arteritis and Differentiation of arteritic from Non-Arteritic Anterior Ischemic Optic Neuropathy

Costello

Zimmerman

Podhajsky

et al. 2004

European Journal of Ophthalmology

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“…Vasculitis that involves large and middle-sized blood vessels with a predisposition for cranial arteries usually develops, and ischemic visual manifestations are the most feared in GCA [ 2 , 3 ]. In addition, thrombocytosis is considered as a risk factor of ischemic event in GCA patients [ 10 – 12 ]. On the other hand, GCA patients often present with clinical manifestation of PMR showing an incidence of 40–60% [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Anterior Uveitis as an Initial Manifestation of Polymyalgia Rheumatica

Tsuda

Tanaka

Kishida

2011

Case Reports in Medicine

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A 74-year-old woman without contributory medical history presented with acute iridocyclitis in the right eye. Although the iridocyclitis disappeared within two weeks under topical steroid, she complained of acute progressing bilateral shoulder pain and morning stiffness of upper extremities. She was diagnosed as having polymyalgia rheumatica (PMR), and iridocyclitis was considered as its related manifestation. PMR and giant cell arteritis (GCA) are closely related conditions and frequently occur together. GCA with uveitis has been rarely noted. However, ocular symptoms in PMR have not been previously mentioned. This is a first reported case of PMR presented with uveitis, without a complication of GCA. This anterior uveitis might be caused by ischemia of the posterior ciliary arteries and their branches.

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“…71,72 In fact, an elevated platelet count (>400 Â 10 3 /L) may be even more specific than both ESR and CRP in the diagnosis of GCA. 73 About 20% to 50% of patients with GCA will also have a normocytic normochromic anaemia.…”

Section: Full Blood Countmentioning

confidence: 99%