Thromboelastography predicting the prognosis of sudden sensorineural hearing loss

Prognosis of sudden deafness remains a challenge in clinics due to inhomogeneity of the disease. Here we report our retrospective study aimed to explore the value of coagulative markers including activated partial thromboplastin time (APTT), prothrombin time (PT), plasma fibrinogen (FIB) and plasma D-Dimer in the prognosis of the patients. The study included a total of 160 patients, of which 92 had valid responses, and 68 had invalid responses and 68 had ineffective responses. APTT, PT, and the levels of FIB and D-D in serum were compared between the two groups, and their prognostic values were determined in terms of area-under-curve (AUC) in receiver operating curve (ROC) analysis, sensitivity and specificity. The correlations of APTT, PT and FIB to hearing loss degree were also assessed. Serum APTT and PT, FIB and D-Dimer levels were lower in patients with sudden deafness that responded poorly to treatments. ROC analysis showed that APTT, PT, FIB and D-Dimer had high AUC, sensitivity and specificity for non-responders, particularly when used in combination (AUC=0.91, sensitivity=86.76%, and specificity=82.61%). Patients with a higher hearing loss degree (>91dB) also demonstrated significantly lower values of APTT and PT and higher levels of serum FIB and D-Dimer than those with a lower hearing loss degree. Our study demonstrated that APTT, PT, and serum levels of FIB and D-D could serve as strong predictors of sudden deafness, potentiating the use of these tests to identify patients that respond poorly to treatments.

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Correlation of coagulation states with prognosis of sudden deafness

Zhang

Wang

Yang

et al. 2023

Journal of Neurophysiology

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Prognostic changes after sudden deafness in patients with inner ear malformations characterized by LSCC: a retrospective study

et al. 2023

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IntroductionThis study aimed to investigate the clinical features and prognosis of sudden sensorineural hearing loss in patients with lateral semicircular canal (LSCC) malformation.MethodsThis study enrolled patients with LSCC malformation and sudden sensorineural hearing loss (SSNHL) who were admitted to Shandong ENT Hospital between 2020 and 2022. We collected and analyzed data on examinations of audiology, vestibular function, and imaging records of patients and summarized the clinical characteristics and prognosis of these patients.ResultsFourteen patients were enrolled. Patients with LSCC malformation was noted in 0.42% of all SSNHL cases during the same period. One patients had bilateral SSNHL and the rest had unilateral SSNHL. Of them, eight and six patients had unilateral and bilateral LSCC malformations, respectively. Flat hearing loss was noted in 12 ears (80.0%) and severe or profound hearing loss was noted in 10 ears (66.7%). After treatment, the total efficacy rate of SSNHL with LSCC malformation was 40.0%. Vestibular function was abnormal in all patients, but only five patients (35.7%) had dizziness. There were statistically significant differences in the vestibular functions between patients with LSCC malformation and matched patients without the malformation hospitalized during the same period (p < 0.05).ConclusionPatients with SSNHL and LSCC malformation had flat-type and severe hearing loss and worse disease prognosis compared to those with SSNHL without LSCC malformation. Vestibular function is more likely to be abnormal; however, there was no significant difference in vestibular symptoms between patients with and without LSCC malformation. LSCC is a risk factor for the prognosis of SSNHL.

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Thromboelastography predicting the prognosis of sudden sensorineural hearing loss

Abstract: Objectives: To explore the association between thromboelastography and the clinical features as well as the prognosis of sudden sensorineural hearing loss (SSNHL).

Cited by 2 publications

References 25 publications

Correlation of coagulation states with prognosis of sudden deafness

Correlation of coagulation states with prognosis of sudden deafness

Prognostic changes after sudden deafness in patients with inner ear malformations characterized by LSCC: a retrospective study

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