Thromboelastometry – method of laboratory diagnostics of hemostasis system disorders

Stomenskaya, Irina S.; Kostrova, Olga Yu.; Struchko, G. Yu.; Тимофеева, Н. И.

doi:10.21145/2499-9954-2017-2-96-98

Cited by 7 publications

(2 citation statements)

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“…The condition of the blood coagulation system of patients was assessed by estimating coagulogram indicators -INR, APTT, Quick prothrombin, antithrombin III, protein S, factors VII and VIII (Kuznetsova, 2011;Stomenskaya et al, 2017).…”

Section: Methodsmentioning

confidence: 99%

Frequency and risk factors of thromboembolic complications in patients with inflammatory bowel diseases

Lishchinskaya

Knyazev

Каграманова

et al. 2022

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Inflammatory bowel diseases (IBD) are characterised by chronic immune inflammation of the mucous membrane and/or the thickness of the intestinal wall, and are also accompanied by disorders of the blood clotting system and the development of a hypercoagulation state. The aim of this study was to identify the frequency of thromboembolic complications (TEC) in IBD patients and to determine the influence of acquired and inherited hypercoagulation factors that contribute to the development of TEC. The clinical status of 1238 IBD patients who were treated in 2019 was evaluated. Of these, 748 patients suffered from ulcerative colitis (UC) and 490 had Crohn's disease (CD). Among the UC patients, there were 369 men (49.3%) and 379 women (50.7%). In 10.2% of patients with UC, there were clinically significant TEC. There were 227 men (46.3%) and 263 women (53.7%) among patients with CD. 7.3% of patients with CD had clinically significant TEC. 112 (9.0 %) of 1238 IBD patients had clinically significant TEC. Among patients with UC (n = 748), 76 (10.2%) showed clinically significant TEC. Among patients with CD (n = 490), 36 (7.3%) had TEC. Of 112 IBD patients with clinically significant TEC, 45 (40.2%) had genetic polymorphisms that increased affinity for fibrinogen, increased platelet aggregation, and contributed to a decrease in the activity of folate cycle enzymes, including methylenetetrahydrofolate reductase, which may be manifested by a moderate increase in homocysteine levels. Of the 45 IBD patients with clinically significant TEC due to inherited factors, 30 (66.6%) patients had UC and 15 (33.7%) patients had CD (HR – 1.038, 95% CI 0.746–1.444; x2 – 0.049; p = 0.83921). 67 patients with IBD (59.8%) who had clinically significant TEC did not have genetic polymorphisms leading to hypercoagulation. Based on the analysis, we can conclude that risk factors for the development of TEC like the status of a smoker, long bed rest, taking hormonal contraceptives, varicose veins of the lower extremities, high activity of the disease, glucocorticosteroids therapy, the extent of intestinal damage in patients with IBD, and genetic factors, should be taken into account by gastroenterologists in the treatment of patients with UC and CD. The hereditary factor of hypercoagulation equally affects the development of TEC, both in patients with UC and CD.

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Section: Methodsmentioning

confidence: 99%

Frequency and risk factors of thromboembolic complications in patients with inflammatory bowel diseases

Lishchinskaya

Knyazev

Каграманова

et al. 2022

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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“…В настоящее время эффективным и дополнительным методом диагностики нарушений системы гемостаза является тромбоэластометрия (ТЭМ), которая выполняется с помощью анализаторов разных фирм. Этот метод позволяет оценить изменения во всех звеньях системы гемостаза в течение нескольких минут, практически у постели больного [5,6] При обработке показателей коагулограммы и тромбоэластометрии выявлено, что только у одной женщины 18 лет с ЗЧМТ не наблюдались изменения в системе гемостаза. Скорее всего, это связано с компенсаторными возможностями молодого организма.…”

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The Importance of Thromboelastometry in the Hemostatic Disorders Diagnosis in Intencive Care Patients With Traumas (Clinical Case)

Kostrova

Stomenskaya

Тимофеева

et al. 2021

EESA

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thromboelastometry and coagulogram in patients with polytrauma. Materials and methods. The results of thromboelastometry (TEM) and standard coagulogram of 12 patients aged 18 to 74 years with a diagnosis of trauma were analyzed. Analysis of thromboelastometry was performed using a ROTEM delta blood analyzer (Tem Innovations GmbH, Germany), which evaluates the physical properties of a clot. Patients' blood stabilized with sodium citrate was placed in special disposable microcuvettes with the addition of various activators of coagulation reactions. The following indicators of thromboelastometry were determined: CT, CFT, angle alpha (α), MCF, A5, A10 in the tests INTEM, EXTEM and FIBTEM. The determination of coagulogram parameters was carried out according to a standard method. The following parameters were identified: APTT, INR, fibrinogen A content, serum fibrin degradation products (SFDP) concentration. Results. Coagulogram and thromboelastometry data at different stages of treatment were compared. In patients with the development of traumatic shock, coagulogram indices were changed to varying degrees depending on the stage of a shock. At the first stage of shock, the analysis showed only a 2-fold increase in SFDP and a slight increase in fibrinogen in dynamics. In a patient with a third stage of traumatic shock, the coagulogram indices were within normal limits, but according to TEM (EXTEM and FIBTEM tests), hypocoagulation was observed due to platelets. Only a coagulogram was evaluated in dynamics, hypocoagulation was observed in parameters of internal and external hemostasis pathways (prolongation of APTT, decrease in IPT and increase in INR), increase in fibrinogen A and SFDP. In the group of male patients with closed craniocerebral injuries, an increase in SFMC in the coagulogram had always been combined with changes in the FIBTEM test during TEM. Conclusion. Thus, in most patients, there is no change in classic coagulogram tests immediately after the injury. At the same time, rotational thromboelastometry makes it possible to fill this deficiency at an earlier date, which indicates a high sensitivity of the method.

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Assessment of hemostasis disorders using thromboelastography in patients with chronic glomerulonephritis and nephrotic syndrome

Berns¹,

Chebotareva²,

Sovetnikov³

et al. 2022

Profil. med.

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Thromboelastometry – method of laboratory diagnostics of hemostasis system disorders

Cited by 7 publications

References 0 publications

Frequency and risk factors of thromboembolic complications in patients with inflammatory bowel diseases

Frequency and risk factors of thromboembolic complications in patients with inflammatory bowel diseases

The Importance of Thromboelastometry in the Hemostatic Disorders Diagnosis in Intencive Care Patients With Traumas (Clinical Case)

Assessment of hemostasis disorders using thromboelastography in patients with chronic glomerulonephritis and nephrotic syndrome

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