Thromboembolism in active ulcerative colitis

Abstract

Inflammatory bowel disease (IBD) has a range of both intestinal and extraintestinal manifestations. Thromboembolism involving the arterial and/or venous systems is rare. Early recognition and treatment of thrombosis in patients with IBD may prevent progression and minimise complications. However, clear guidelines on the duration of treatment and indications for primary prophylaxis need to be established. We report a case of a young patient with ulcerative colitis, who developed multiple site arterial and venous thrombosis, all occurring within short intervals of each other.

The Promising Future of Low-Molecular-Weight Heparin in Pediatric Cerebral Venous Sinus Thrombosis Occurring as a Rare Complication of Ulcerative Colitis

“…The most eminent genetic risk factors for venous thrombosis are deficiencies of the natural anticoagulants (protein C, protein S, and anti-thrombin III) and elevated levels of several pro-coagulants platelets, factor V and VIII, fibrinopeptides, and fibrinogen [ 8 ]. Raised levels of PT and D-dimers on admission were suggestive of venous thromboembolism in our patient.…”

Recurrent Unprovoked Venous Thrombosis (Cerebral Sinus Thrombosis and Mesenteric Vein Thrombosis) in Young Patient with Crohn’s Disease: A Case Report and Review

“…The current practice in treatment of IBD patients with venous thromboembolism is the same as for non-IBD patients. In the acute setting, anticoagulation with low-molecular-weight heparin or unfractionated heparin is recommended, with transition to oral anticoagulation [ 13 ].…”

Digit Necrosis After Hand Surgery in Pregnancy: A Case Report

“…Ulcerative colitis (UC) has been implicated as a risk factor for ATE and VTE. [9][10][11][12][13][14][15] Specifically, patients have a 3fold increased risk of deep vein thrombosis (DVT) and pulmonary embolism (PE) compared to the general population. 15 There are a number of case reports describing spontaneous thromboembolism in the upper extremity in the setting of UC.…”

“…[9][10][11][12][13][14][15] Specifically, patients have a 3fold increased risk of deep vein thrombosis (DVT) and pulmonary embolism (PE) compared to the general population. 15 There are a number of case reports describing spontaneous thromboembolism in the upper extremity in the setting of UC. [1][2][3] One case reports describes a 58 year old woman with a history of severe UC presenting with severe ischemic rest pain due to a brachiocephalic trunk thrombosis resulting in ipsilateral hand microembolism.…”